Cat. No. | Product name | CAS No. |
DC8337 |
Fluensulfone
Featured
Fluensulfone is a new nematicide of the fluoroalkenyl thioether group that has significantly reduced environmental impact with low toxicity to non-target insects and mammals. |
318290-98-1 |
DC11413 |
Flumatinib
Featured
Flumatinib is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRβ and c-Kit respectively. |
895519-90-1 |
DC8910 |
Flunarizine dihydrochloride
Featured
Flunarizine is a selective calcium entry blocker. |
30484-77-6 |
DC22475 |
FITC
Featured
Fluorescein isothiocyanate(FITC) is a derivative of fluorescein used in wide-ranging applications including flow cytometry. |
3326-32-7 |
DC10424 |
Fluorescein-5-maleimide
Featured
Fluorescein-5-maleimide is a fluorescent thiol-reactive dye used to conjugate fluorescein to proteins (excitation: 494 nm, emission: 519 nm). |
75350-46-8 |
DC9669 |
Fluoroclebopride
Featured
Fluoroclebopride is useful chemical for PET image study. |
154540-49-5 |
DC9078 |
Fluoxetine Hydrochloride
Featured
Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
56296-78-7 |
DC9164 |
Flupenthixol dihydrochloride
Featured
Flupenthixol dihydrochloride is a typical antipsychotic of the thioxanthene class that acts as an antagonist at dopamine D2 receptors (Ki = 0.38 nM) and an inverse agonist at serotonin 5-HT2A receptors (Ki = 7 nM).1 It has also been identified as an inhib |
51529-01-2 |
DC10158 |
Fluralaner
Featured
Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels. |
864731-61-3 |
DC12247 |
Fluspirilene (R 6218; Redeptin)
Featured
Fluspirilene is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic drug used for schizophrenia. |
1841-19-6 |
DC10020 |
Fluticasone furoate
Featured
Fluticasone furoate is a synthetic trifluorinated corticosteroid with potent anti-inflammatory activity. |
397864-44-7 |
DC10678 |
Fluticasone
Featured
Fluticasone is a synthetic glucocorticoid which is used in some countries to treat nasal symptoms. |
90566-53-3 |
DC22228 |
Fluzoparib
Featured
Fluzoparib (SHR 3162) is a selective poly [ADP-ribose] polymerase 1 (PARP1) and poly [ADP-ribose] polymerase 2 inhibitor (PARP2), being developed by Jiangsu HengRui Medicine, for the treatment of cancer. PARP enzymes play a vital role in repair of DNA dam |
1358715-18-0 |
DC10826 |
FM-381
Featured
FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively. |
2226521-65-7 |
DC7937 |
LFM-A13
Featured
FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC₅₀’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK). |
244240-24-2 |
DC26027 |
FMF-04-159-2
Featured
FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. |
2364489-81-4 |
DC10194 |
FMK 9a
Featured
FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay. |
1955550-51-2 |
DC7696 |
FMK
Featured
Fmk is an irreversible ribosomal S6 kinase inhibitor 1/2 inhibitor. |
821794-92-7 |
DC8703 |
Fmoc-Val-Cit-PAB
Featured
Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC). |
159858-22-7 |
DC8701 |
Fmoc-Val-Cit-PAB-PNP
Featured
Fmoc-Val-Cit-PAB-PNP is a peptide prodrug linker, is a linker for antibody-drug-conjugation (ADC). |
863971-53-3 |
DC21019 |
FOBISIN 101
Featured
FOBISIN 101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. |
1370281-06-3 |
DC4207 |
Fondaparinux sodium
Featured
Fondaparinux sodium is a synthetic and specific inhibitor of activated Factor X (Xa). |
114870-03-0 |
DCAPI1249 |
Acesulfame Potassium
Featured
Acesulfame potassium is an artificial sweetener. Acesulfame potassium (long-term) affects cognitive functions, potentially via altering neuro-metabolic functions in mice. |
55589-62-3 |
DC8285 |
Acotiamide HCl
Featured
Acotiamide monohydrochloride trihydrate is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia. Acotiamide monohydrochloride trihydrate enhances acetylcholine released by enteric neurons through muscarinic |
773092-05-0 |
DC7849 |
DTP3
Featured
For the detailed information of DTP3, the solubility of DTP3 in water, the solubility of DTP3 in DMSO, the solubility of DTP3 in PBS buffer, the animal experiment (test) of DTP3, the cell expriment (test) of DTP3, the in vivo, in vitro and clinical trial test of DTP3, the EC50, IC50,and affinity,of DTP3, Please contact DC Chemicals.. |
1809784-29-9 |
DC7016 |
JNJ40411813
Featured
For the detailed information of JNJ40411813, the solubility of JNJ40411813 in water, the solubility of JNJ40411813 in DMSO, the solubility of JNJ40411813 in PBS buffer, the animal experiment (test) of JNJ40411813, the cell expriment (test) of JNJ40411813, the in vivo, in vitro and clinical trial test of JNJ40411813, the EC50, IC50,and Affinity of JNJ40411813, Please contact DC Chemicals.. |
1127498-03-6 |
DC7546 |
LHW090-A7
Featured
For the detailed information of LHW090-A7, the solubility of LHW090-A7 in water, the solubility of LHW090-A7 in DMSO, the solubility of LHW090-A7 in PBS buffer, the animal experiment (test) of LHW090-A7, the cell expriment (test) of LHW090-A7, the in viv |
1308256-94-1 |
DC7580 |
Naxagolide
Featured
For the detailed information of Naxagolide, the solubility of Naxagolide in water, the solubility of Naxagolide in DMSO, the solubility of Naxagolide in PBS buffer, the animal experiment (test) of Naxagolide, the cell expriment (test) of Naxagolide, the in vivo, in vitro and clinical trial test of Naxagolide, the EC50, IC50,and Affinity of Naxagolide, Please contact DC Chemicals.. |
88058-88-2 |
DC7618 |
NI-(S)-BPB-GLY
Featured
For the detailed information of NI-(S)-BPB-GLY, the solubility of NI-(S)-BPB-GLY in water, the solubility of NI-(S)-BPB-GLY in DMSO, the solubility of NI-(S)-BPB-GLY in PBS buffer, the animal experiment (test) of NI-(S)-BPB-GLY, the cell expriment (test) of NI-(S)-BPB-GLY, the in vivo, in vitro and clinical trial test of NI-(S)-BPB-GLY, the EC50, IC50,and Affinity of NI-(S)-BPB-GLY, Please contact DC Chemicals.. |
96293-19-5 |
DC8441 |
Nitenpyram
Featured
Nitenpyram is a chemical frequently used as an insecticide in agriculture and veterinary medicine. The compound is an insect neurotoxin belonging to the class of neonicotinoids which works by blocking neural signaling of the central nervous system. |
150824-47-8 |
DC8174 |
Pexmetinib(ARRY-614)
Featured
Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia. |
945614-12-0 |
DC7551 |
RG3039(PF-06687859)
Featured
For the detailed information of PF-0668759, the solubility of PF-0668759 in water, the solubility of PF-0668759 in DMSO, the solubility of PF-0668759 in PBS buffer, the animal experiment (test) of PF-0668759, the cell expriment (test) of PF-0668759, the |
1005504-62-0 |
DC22285 |
praeruptorin B
Featured
For the detailed information of praeruptorin B, the solubility of praeruptorin B in water, the solubility of praeruptorin B in DMSO, the solubility of praeruptorin B in PBS buffer, the animal experiment(test) (test) of praeruptorin B, the cell expriment (test) of praeruptorin B, the in vivo, in vitro and clinical trial test of praeruptorin B, the EC50, IC50,and Affinity of praeruptorin B,, please contact DC Chemicals.. |
73069-28-0 |
DC7616 |
RO 15-3890
Featured
For the detailed information of RO 15-3890, the solubility of RO 15-3890 in water, the solubility of RO 15-3890 in DMSO, the solubility of RO 15-3890 in PBS buffer, the animal experiment (test) of RO 15-3890, the cell expriment (test) of RO 15-3890, the in vivo, in vitro and clinical trial test of RO 15-3890, the EC50, IC50,and Affinity of RO 15-3890, Please contact DC Chemicals.. |
84378-44-9 |
DC8209 |
SD-70
Featured
A small molecule tumor translocation inhibitor that inhibits the prostate cancer cell transcriptional program, in part by inhibition of the demethylase KDM4C (IC50=30 uM). |
332173-89-4 |
DC7507 |
HIV-1 integrase inhibitor 8
Featured
HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1]. |
1568-80-5 |
DC7973 |
Tenovin-2
Featured
For the detailed information of Tenovin-2, the solubility of Tenovin-2 in water, the solubility of Tenovin-2 in DMSO, the solubility of Tenovin-2 in PBS buffer, the animal experiment (test) of Tenovin-2, the cell expriment (test) of Tenovin-2, the in vivo, in vitro and clinical trial test of Tenovin-2, the EC50, IC50,and affinity,of Tenovin-2, Please contact DC Chemicals.. |
666211-30-9 |
DC8176 |
Tradipitant(VLY-686)
Featured
For the detailed information of Tradipitant(VLY-686), the solubility of Tradipitant(VLY-686) in water, the solubility of Tradipitant(VLY-686) in DMSO, the solubility of Tradipitant(VLY-686) in PBS buffer, the animal experiment (test) of Tradipitant(VLY-686), the cell expriment (test) of Tradipitant(VLY-686), the in vivo, in vitro and clinical trial test of Tradipitant(VLY-686), the EC50, IC50,and affinity,of Tradipitant(VLY-686), For the detailed information of Tradipitant(VLY-686), the solubility of Tradipitant(VLY-686) in water, the solubility of Tradipitant(VLY-686) in DMSO, the solubility of Tradipitant(VLY-686) in PBS buffer, the animal experiment (test) of Tradipitant(VLY-686), the cell expriment (test) of Tradipitant(VLY-686), the in vivo, in vitro and clinical trial test of Tradipitant(VLY-686), the EC50, IC50,and affinity,of Tradipitant(VLY-686), Please contact DC Chemicals.. |
622370-35-8 |
DC6917 |
Vonoprazan
Featured
For the detailed information of Vonoprazan, the solubility of Vonoprazan in water, the solubility of Vonoprazan in DMSO, the solubility of Vonoprazan in PBS buffer, the animal experiment (test) of Vonoprazan, the cell expriment (test) of Vonoprazan, the in vivo, in vitro and clinical trial test of Vonoprazan, the EC50, IC50,and affinity,of Vonoprazan, For the detailed information of Vonoprazan, the solubility of Vonoprazan in water, the solubility of Vonoprazan in DMSO, the solubility of Vonoprazan in PBS buffer, the animal experiment (test) of Vonoprazan, the cell expriment (test) of Vonoprazan, the in vivo, in vitro and clinical trial test of Vonoprazan, the EC50, IC50,and affinity,of Vonoprazan, Please contact DC Chemicals.. |
881681-00-1 |
DC7342 |
Foretinib(XL880)
Featured
Foretinib (GSK1363089; XL880; EXEL-2880; GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. |
849217-64-7 |
DC9333 |
Formoterol (Fumarate)
Featured
Formoterol fumarate(Foradil) is a potent, selective and long-acting β2-adrenoceptor agonist. |
43229-80-7 |
DC1017 |
Forskolin
Featured
Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC). |
66575-29-9 |
DC4201 |
Fosaprepitant dimeglumine
Featured
Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist. |
265121-04-8 |
DC5882 |
Fosbretabulin disodium
Featured
Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. |
168555-66-6 |
DC12068 |
Fosmidomycin sodium salt
Featured
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial drug, which is active against both Gram-negative and Gram-positive bacteria. |
66508-37-0 |
DC23114 |
R788 disodium hexahydrate
Featured
Fostamatinib (R788) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM. |
914295-16-2 |
DC23893 |
Foxy-5(Wnt5a peptide mimetic)
Featured
Foxy-5 is a novel Wnt-5A mimicking hexapeptide that inhibits breast cancer metastasis in vivo by targeting cell motility. |
881188-51-8 |
DC10510 |
FPH1 (BRD-6125)
Featured
FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes. |
708219-39-0 |
DC10947 |
FPL64176
Featured
FPL64176 is a potent L-type Ca++ channel activator with EC50 of 16 nM. |
120934-96-5 |
DC8720 |
FPS-ZM1
Featured
FPS-ZM1 is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively. |
945714-67-0 |
DC21025 |
FR900098 sodium salt
Featured
FR 900098 is a derivative of fosmidomycin that inhibits DOXP reductoisomerase, demonstrates antimalarial activity with IC50 of 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively.. |
73226-73-0 |
DC23729 |
FR-901464
Featured
FR-901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases.. |
146478-72-0 |
DC9887 |
FRAX1036
Featured
FRAX1036 is a novel ATP-competitive small molecule inhibitor of group I p21-activated Kinases (PAKs). |
1432908-05-8 |
DC8003 |
FRAX-486
Featured
FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt; less potent for PAK4(IC50=779 nM). |
1232030-35-1 |
DC8154 |
FRAX 597
Featured
FRAX597 is a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. |
1286739-19-2 |
DC23050 |
fraxinellone
Featured
Fraxinellone is a selective blocker of voltage-dependent Ca2+ channel, which possesses antimicrobial, anti-inflammatory, neuroprotective and vasorelaxing activities. |
28808-62-0 |
DC7902 |
Fruquintinib (HMPL-013)
Featured
Fruquintinib (HMPL-013) is a novel small molecule compound that selectively inhibits vascular endothelial growth factor receptors (VEGFRs). |
1194506-26-7 |
DC20272 |
FT113
Featured
FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. |
1630808-89-7 |
DC11554 |
FT-671
Featured
FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain). |
1959551-26-8 |
DC11029 |
FTBMT
Featured
FTBMT is a novel selective GPR52 agonist of GPR52, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively. |
1358575-02-6 |
DC8421 |
FTI 277 HCl
Featured
FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. |
180977-34-8 |
DC3154 |
Fingolimod HCl(FTY-720)
Featured
FTY720 (Fingolimod, Gilenya) is a S1P antagonist with IC50 of 0.033 nM. |
162359-56-0 |
DC11394 |
Fulacimstat(BAY 1142524)
Featured
Fulacimstat(BAY 1142524) is a small molecule chymase inhibitor. |
1488354-15-9 |
DC4200 |
Fulvestrant
Featured
Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.094 nM. |
129453-61-8 |
DC8855 |
Fumagillin
Featured
Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis. |
23110-15-8 |
DCAPI1020 |
Fumalic acid (Ferulic acid)
Featured
Fumalic acid (Ferulic acid) |
1135-24-6 |
DC11235 |
Furamidine dihydrochloride
Featured
Furamidine dihydrochloride (NSC 305831) tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM. |
55368-40-6 |
DC10447 |
FX1
Featured
FX1 is a novel specific inhibitor of the B cell lymphoma 6 (BCL6). |
1426138-42-2 |
DC8222 |
G007-LK
Featured
G007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. |
1380672-07-0 |
DC24027 |
STING Agonist-1(G-10)
Featured
G10 (STING Agonist 1) is a novel human-specific STING agonist. |
702662-50-8 |
DC10814 |
G-15
Featured
G-15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM). |
1161002-05-6 |
DC10501 |
G1T28(Trilaciclib)
Featured
G1T28(Trilaciclib) is a potential first-in-class, short-acting IV CDK4/6 inhibitor being developed to preserve hematopoietic stem cells and enhance immune system function during chemotherapy. |
1374743-00-6 |
DC10816 |
G-36
Featured
G-36 is a cell-permeable non-steroidal antagonist of GPER, inhibiting activation by either 17β-estradiol or the GPER-selective agonist G-1(IC50 = 112 and 165 nM, respectively). |
1392487-51-2 |
DC12438 |
G6PD activator AG1
Featured
G6PD activator AG1 (AG1) is a specific, small molecule that increases the activity of the wild-type, Canton mutant (R459L, EC50=3 uM) and several other common G6PD mutants; displays no effect on the dimerization or activity of several other NAD- or NADP+-dependent dimeric or tetrameric enzymes, including 6PGD, GAPDH, ALDH2, and ALDH3A1; attenuates ROS-induced pericardial edema in a G6PD-dependent manner in zebrafish, reduces hemolysis of human erythrocytes |
421581-52-4 |
DC7792 |
G-749
Featured
G-749 is an inhibitor of Fms-like tyrosine receptor kinase 3 (FLT3) with IC50 values ranging from 2.1 to 38.1 nM for wild-type and mutant (constitutively active) FLT3s in Ba/F3 cells expressing recombinant receptors. |
1457983-28-6 |
DC8954 |
Gabapentin
Featured
Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain. |
60142-96-3 |
DCAPI1037 |
Gadodiamide (Omniscan)
Featured
Gadodiamide is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Target: OthersGadodiamide(Omniscan) is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Gadodiamide is a contrast medium for cranial and spinal magnetic resonance imaging (MRI) and for general MRI of the body after intravenous administration. The product provides contrast enhancement and facilitates visualisation of abnormal structures or lesions in various parts of the body including the central nervous system (CNS). A recent review takes the question of toxicity caused by loss of gadolinium from the complex. "The challenge for nephrologists includes (a) evidence of transmetallation, such as gadolinium deposits in bone, increased urinary zinc excretion, iron-transferrin dissociation or 'spurious hypocalcemia' in exposed people"。 |
122795-43-1 |
DC11053 |
GAK inhibitor 49
Featured
GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K). |
319492-82-5 |
DC9859 |
GAL-021
Featured
GAL-021 is a new intravenous BKCa-channel blocker. |
1380341-99-0 |
DC7861 |
(-)-Narwedine
Featured
Galantamine(Narwedin) is a competitive and reversible cholinesterase(AChE) inhibitor. |
510-77-0 |
DC10133 |
Gambogic Acid
Featured
Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, respectively. |
2752-65-0 |
DC21197 |
Ganaplacide
Featured
Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains. |
1261113-96-5 |
DC7320 |
Ganetespib(STA-9090)
Featured
Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells. |
888216-25-9 |
DC8877 |
Ganirelix
Featured
Ganirelix is a man-made form of a protein that reduces the amount of certain hormones in the body, including estrogen. |
124904-93-4 |
DC7129 |
GANT61(NSC 136476)
Featured
GANT 61(NSC 136476) is a small molecule inhibitor of Gli1 and Gli2. |
500579-04-4 |
DC20388 |
GAPDS
Featured
GAPDS is a small molecule that targets the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH). |
917773-99-0 |
DC26031 |
Gardiquimod trifluoroacetate
Featured
Gardiquimod trifluoroacetate is a specific TLR7 agonist which can also inhibit HIV-1 reverse transcriptase. |
1159840-61-5 |
DC12671 |
Gboxin
Featured
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. |
2101315-36-8 |
DC7130 |
GBR 12935 dihydrochloride
Featured
GBR 12935 is a potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes). |
67469-81-2 |
DC10474 |
GBT-440(Voxelotor)
Featured
GBT-440(Voxelotor) is a novel small molecule hemoglobin modifier which increases hemoglobin oxygen affinity. |
1446321-46-5 |
DC10896 |
GCN2-IN-1
Featured
GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay. |
1448693-69-3 |
DC7416 |
Taselisib(GDC-0032)
Featured
GDC-0032 is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with IC50 of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ. |
1282512-48-4 |
DC3109 |
Ipatasertib (GDC-0068)
Featured
GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. |
1001264-89-6 |
DC10153 |
GDC-0077
Featured
GDC-0077 is an orally available PI3K inhibitor with potential antineoplastic activity. GDC-0077 is extracted from patent WO 2017001645 A1, formula I. |
2060571-02-8 |
DC9708 |
Paxalisib (GDC-0084)
Featured
GDC-0084 (RG7666), is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. |
1382979-44-3 |
DC8597 |
Gdc-0152
Featured
GDC-0152 is a potent inhibitor of IAPs; binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with K(i) values of 28, 14, 17, and 43 nM, respectively. |
873652-48-3 |
DC8519 |
GDC046
Featured
GDC046 is a potent lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile. |
1258292-64-6 |
DC10485 |
GDC0575(ARRY-575,RG7441)
Featured
GDC0575(ARRY-575,RG7441)is a small molecule inhibitor of cell cycle checkpoint kinase 1 (Chk1), with potential chemosensitization activity. |
1196541-47-5 |
DC8000 |
GDC-0623
Featured
GDC-0623 is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP). |
1168091-68-6 |
DC9942 |
GDC-0853(RG7845)
Featured
GDC-0853 is orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. |
1434048-34-6 |
DC1054 |
GDC0941(Pictilisib)
Featured
GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively. |
957054-30-7 |
DC4177 |
Cobimetinib(GDC-0973; XL518)
Featured
GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase, also known as MEK, a serine/threonine kinase that is a component of the RAS/RAF/MEK/ERK pathway. |
934660-93-2 |
DC5081 |
Apitolisib
Featured
GDC-0980 (RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM, respectively. Also a mTOR inhibitor with Ki of 17 nM, and highly selective versus others PIKK family kinases. |
1032754-93-0 |
DC7766 |
Ravoxertinib
Featured
GDC-0994 is a potent, orally available ERK1/2 inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively. Phase 1. |
1453848-26-4 |
DC22324 |
GDP366
Featured
GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. |
501698-03-9 |
DC10667 |
Gea3162
Featured
Gea 3162 is a potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). GEA 3162 stimulates cGMP production in platelets, granulocytes, and polymorphonuclear leukocytes. |
144576-10-3 |
DC11504 |
GeA-69
Featured
GeA-69(GeA69) is a potent, selective, allosteric, cell-active PARP14 macrodomain 2 (MD2) inhibitor with Kd of 0.86 uM in ITC assays. |
2143475-98-1 |
DC10721 |
Gefapixant(AF-219,MK-7264)
Featured
Gefapixant(AF-219,MK-7264) is novel P2X3 receptor antagonist. |
1015787-98-0 |
DC2103 |
Gefitinib (ZD1839)
Featured
Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. |
184475-35-2 |
DC12392 |
Gemcabene
Featured
Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP. |
183293-82-5 |
DC8487 |
Gemcitabine elaidate
Featured
Gemcitabine elaidate is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. |
210829-30-4 |
DC2107 |
Gemcitabine HCl (Gemzar,LY188011)
Featured
Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively,showed potent activity against COVID-19(SARS-COV-2) with EC50 MERS-COV(1.216), SARS-COV(4.9 |
122111-03-9 |
DC10590 |
Gemcitabine monophosphate
Featured
Gemcitabine monophosphate disodium salt, also called GemMP, is a monophosphate derivative of Gemcitabine. |
1638288-31-9 |
DC3159 |
Gemifioxacin
Featured
Gemifloxacin mesylate (trade name Factive, Oscient Pharmaceuticals) is an oral broad-spectrum quinolone antibacterial agent used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. |
210353-53-0 |
DC2092 |
Genistein
Featured
Genistein is a highly specific inhibitor of protein tyrosine kinase (PTK). |
446-72-0 |
DC2093 |
Genistin
Featured
Genistin is an isoflavone glycoside found in soy-based products. Can be used as a negative control for the PTK inhibitor Genistein |
529-59-9 |
DCAPI1064 |
mixtures of three isomers (Gentamicins C1, C2, and C1(subA).
Featured
Gentamycin sulfate (Gentacycol) |
1405-41-0 |
DC7417 |
Genz-123346
Featured
Genz-123346 free base is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; IC50 for GM1 inhibition is 14 nM. |
491833-30-8 |
DC10161 |
Gepotidacin
Featured
Gepotidacin (GSK2140944) is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. |
1075236-89-3 |
DC7132 |
GF 109203X
Featured
GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor. |
133052-90-1 |
DC21043 |
GGTI 2417
Featured
GGTI 2417 is the methyl ester prodrug of GGTI-2418, a highly potent, competitive, and selective inhibitor of GGTase I. |
501010-05-5 |
DC21044 |
GGTI 2418
Featured
GGTI 2418 (PTX 100) is a highly potent, competitive, and selective peptidomimetic inhibitor of geranylgeranyltransferase I (GGTI) with IC50 of 9.5 nM, displays 5,600-fold selectivity over FTase. |
501010-06-6 |
DC21042 |
GGTI-2147
Featured
GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM). |
191102-87-1 |
DC11246 |
Ghrelin agonist HM01
Featured
Ghrelin agonist HM01 is a novel potent, orally available ghrelin (GHS-R) agonist with Ki of 1.42 nM (human GHS-R1a), induces potent activation of intracellular calcium signaling with EC50 of 1.25 nM. |
1394860-28-6 |
DC10883 |
GI254023X
Featured
GI254023X is a potent MMP9 and ADAM10 inhibitor with IC50s of 2.5 and 5.3 nM, respectively. |
260264-93-5 |
DC10490 |
GIBH-130
Featured
GIBH-130 is a novel inhibitor of neuroinflammation effective in Alzheimer’s disease models. |
1252608-59-5 |
DC7432 |
Givinostat (ITF2357)
Featured
Givinostat (ITF2357) is a potent HDAC inhibitor for maize HD2, HD1B and HD1A with IC50 of 10 nM, 7.5 nM and 16 nM. Phase 1/2. |
732302-99-7 |
DC10081 |
GJ103
Featured
GJ103 is an active analog of the read-through compound GJ072. |
1459687-89-8 |
DC10080 |
GJ103 (sodium salt)
Featured
GJ103 sodium salt is an active analog of the read-through compound GJ072. |
1459687-96-7 |
DC9855 |
GK921
Featured
GK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 uM in cancer cell lines. |
1025015-40-0 |
DC8118 |
GKT137831(Setanaxib)
Featured
GKT137831 is a novel and specific dual Nox1/Nox4 inhibitor with Ki of 140±40 nM and 110±30 nM; a potent inhibitor of fibrosis and hepatocyte apoptosis. |
1218942-37-0 |
DC21049 |
Glabrescione B
Featured
Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction, inhibits Hh signaling by impairing Gli1 function; inhibits the growth of Hedgehog-dependent tumor cells in vitro and in vivo, inhibits Gli1-dependent growth of cerebellum-derived normal progenitors; inhibits the growth of Gli-dependent medulloblastoma and tumor-derived stem-like cells; inhibits the growth of Gli-dependent basal cell carcinoma in vitro and in vivo. |
65893-94-9 |
DC10130 |
Glabridin
Featured
Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract |
59870-68-7 |
DC10818 |
ABT-493(Glecaprevir)
Featured
Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. |
1365970-03-1 |
DC11296 |
GLP-26
Featured
GLP-26 is a novel potent HBV capsid modulator that reduces secreted HBeAg in HepNTCPDL cells transfected with HBV wild type with EC50 of 0.7 uM. |
2133017-36-2 |
DC8375 |
GLPG0634 analogue
Featured
GLPG0634 (analog) is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents. |
1206101-20-3 |
DC11803 |
GLPG-1690(Ziritaxestat)
Featured
GLPG-1690 is a first-in-class, potent, competitive autotaxin inhibitor with Ki/IC50 of 15 nM/131 nM. |
1628260-79-6 |
DC10753 |
GLPG-1837(ABBV-974)
Featured
GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator. |
1654725-02-6 |
DC26048 |
GLS1 Inhibitor
Featured
GLS1 inhibitor is an inhibitor of glutaminase 1 |
1832646-52-2 |
DC21052 |
GLS 4(Morphothiadin)
Featured
GLS4 (Morphothiadin) is a potent inhibitor of HBV capsid assembly, inhibits HBV replication (EC50=62.24 nM) and reduces HBV-DNA levels in HepG.2.2.15 cells (IC50=14 nM), shows efficacy against ADV-resistant HBV mutations. |
1092970-12-1 |
DC10003 |
PF-06291874(glucagon receptor antagonists-4)
Featured
glucagon receptor antagonists-4 is a highly potent glucagon receptor antagonist. |
1393124-08-7 |
DC11543 |
Glumetinib
Featured
Glumetinib (SCC 244) is a novel potent and highly selective inhibitor of c-Met kinase with IC50 of 0.42 nM. |
1642581-63-2 |
DC9529 |
Glutaminase C-IN-1
Featured
Glutaminase C-IN-1 (968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts. |
311795-38-7 |
DC11009 |
GLX351322
Featured
GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M. |
835598-94-2 |
DC8779 |
Glycopyrrolate
Featured
Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. |
596-51-0 |
DC11454 |
Gly-Pro-pNA
Featured
Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). |
103213-34-9 |
DC10874 |
GlyT2-IN-1(YODA 1)
Featured
GlyT2-IN-1(YODA 1) is a glycine transporters GLYT2 inhibitor. |
448947-81-7 |
DC7135 |
GM6001 (galardin, ilomastat)
Featured
GM6001 (galardin, ilomastat) is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4-27 nM. |
142880-36-2 |
DC7418 |
DNL201
Featured
GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM. |
1374828-69-9 |
DC10907 |
GNE-131
Featured
GNE-131 is a novel NaV1.7 inhibitor with IC50 0.003uM,improving metabolic stability,efficacy in mouse IEM model at C-plasma <2.8uM. |
1629063-81-5 |
DC8410 |
GNE-317
Featured
GNE-317 is a potent, brain-penetrant PI3K inhibitor. |
1394076-92-6 |
DC10106 |
GNE-3511
Featured
GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors. |
1496581-76-0 |
DC8257 |
GNE 477
Featured
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR. |
1032754-81-6 |
DC8502 |
GNE-490
Featured
GNE-490 is a highly selective pan-PI3K inhibitor and demonstrates selectivity over mTOR. |
1033739-92-2 |
DC7953 |
GNE-493
Featured
GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. |
1033735-94-2 |
DC10546 |
GNE-495
Featured
GNE-495 is a potent and Selective MAP4K4 Inhibitor with IC50 of 3.7 nM. |
1449277-10-4 |
DC26078 |
GNE-616
Featured
GNE-616 (GNE616) is a highly potent, metabolically stable, subtype selective inhibitor of Nav1.7 with Ki of 0.79 nM (hNav1.7). |
2244895-99-4 |
DC10096 |
GNE-617
Featured
GNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. |
1362154-70-8 |
DC12495 |
GNE-6640
Featured
GNE-6640 is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM). |
2009273-67-8 |
DC11555 |
GNE-6776
Featured
GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM . |
2009273-71-4 |
DC11729 |
GNE-781
Featured
GNE-781 is a potent, selective, non-CNS penetrant, orally active CBP/p300 bromodomain inhibitor with IC50 of 0.94/1.2 nM in TR-FRET assays. |
1936422-33-1 |
DC7419 |
GNE-7915
Featured
GNE-7915 is a highly potent, selective, and brain-penetrable LRRK2 small molecule inhibitor with IC50 of 9 nM in cellular LRRK2 assay; > 100 fold selectivity against a panel of 187 kianses(Ki). |
1351761-44-8 |
DC26024 |
GNE-8324
Featured
GNE-8324 is a potent and selective NMDA receptor PAM. |
1698901-76-6 |
DC7629 |
GNE-9605
Featured
GNE-9605 is a highly potent and selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor |
1536200-31-3 |
DC1062 |
GNF-2
Featured
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, inhibiting the proliferation of the Bcr-Abl-expressing cells with IC50 of 138 nM. |
778270-11-4 |
DC7420 |
GNF-5
Featured
GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22±0.1 uM (Wild type Abl). |
778277-15-9 |
DC7136 |
GNF-5837
Featured
GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). |
1033769-28-6 |
DC9285 |
GNF-7
Featured
GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively. |
839706-07-9 |
DC7660 |
Go 6983
Featured
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ. |
133053-19-7 |
DC22100 |
GO289
Featured
GO289 (GO-289, GO 289) is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM in in vitro kinase assays, shows minor effects on CKIδ and CKIα activity in vitro. |
694522-87-7 |
DC20393 |
Golgicide A
Featured
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM. |
1139889-93-2 |
DC26017 |
Golotimod (SCV-07)
Featured
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. |
229305-39-9 |
DC23028 |
Gomisin A
Featured
Gomisin A has anti-inflammatory, antihypertensive, neuroprotective, and anti-proliferation properties, it induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal tran |
58546-54-6 |
DC12542 |
GOT1 inhibitor 2c
Featured
GOT1 inhibitor 2c is a first-in-class, non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with IC50 of 8.2 uM.. |
732973-87-4 |
DC9375 |
GPDA
Featured
GPDA(Glycylproline p-nitroanilide tosylate) is the substarate of X-Prolyl dipeptidyl-aminopeptidase in the enzyme assay. |
65096-46-0 |
DC7137 |
Filgotinib(GLPG0634)
Featured
Filgotinib (GLPG0634) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. Filgotinib can effectively inhibit the activities of JAK1, JAK2, JAK3 and TYK2 with IC50 values of 10 nM, 28 nM, 810 nM and 116 nM, respectively. Filgotinib also inhibits HIV-1 driven gene transcription and reduces proliferation of HIV-1 infected cells. Filgotinib can be used in the study of rheumatoid arthritis and inflammatory bowel disease. |
1206161-97-8 |
DC8593 |
GPR120 Compound A
Featured
GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 µm) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1). |
1599477-75-4 |
DC8206 |
GPR39-C3
Featured
GPR39-C3 is the first potent, selective and orally bioavailable GPR39 agonist with an EC50 ~0.8 nM for human GPR39 and ~0.4 nM for rodent GPR39. |
1621175-65-2 |
DC20076 |
GPR4 antagonist 3(NE 52-QQ57 )
Featured
GPR4 antagonist 3 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. Anti-inflammatory activities. |
1401728-56-0 |
DC26114 |
GpTx-1
Featured
GpTx-1 is a potent, selective, 34-residue peptide antagonist of Nav1.7 sodium channel with IC50 of 10 nM, displays 20- and 1000- fold selectivity over NaV1.4 and NaV1.5.. |
1661050-12-9 |
DC21064 |
GR-127935 hydrochloride
Featured
GR-127935 potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor. |
148642-42-6 |
DC11090 |
GR3027
Featured
GR3027 (Golexanolone) is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC. |
2089238-18-4 |
DC21066 |
GR73632
Featured
GR-73632 is a potent and selective tachykinin NK1 receptor agonist with EC50 of 2 nM, promotes differentiation but not survival of rat chromaffin cells in vitro.. |
133156-06-6 |
DC9299 |
GRA Ex-25
Featured
GRA Ex-25 is an orally active human glucagon receptor antagonist in a transgenic murine pharmacodynamic model at 10 and 30 mpk. |
307983-31-9 |
DC22629 |
GRL-0617
Featured
GRL-0617 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM. |
1093070-16-6 |
DC12579 |
GS-6207
Featured
GS-6207 (GS6207, GS-CA1) is a potent, selective inhibitor of HIV-1 capsid function with potency and potential to be clinically effective against a broad range of HIV-1 strains.. |
2189684-45-3 |
DC7805 |
CID 121433863
Featured
GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate. |
379270-37-8 |
DC9294 |
Tenofovir Alafenamide Hemifumarate
Featured
GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate. |
1392275-56-7 |
DC7138 |
GS-9620(Vesatolimod)
Featured
GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7(TLR-7) in chimpanzees with chronic HBV infection. |
1228585-88-3 |
DC8006 |
GS967(GS-458967)
Featured
GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa). |
1262618-39-2 |
DC7626 |
GS9973(Entospletinib)
Featured
GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. Phase 2. |
1229208-44-9 |
DC23876 |
GSA-10
Featured
GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay. |
300833-95-8 |
DC5147 |
Molibresib (I-BET-762)
Featured
GSK 525762A is a potent small molecule inhibitors that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4). |
1260907-17-2 |
DC8360 |
GSK 5959
Featured
GSK 5959 is a potent, cell-permeable inhibitor of the BRPF1 bromodomain (IC50 = 80 nM). |
901245-65-6 |
DC7654 |
GSK J4 HCl
Featured
GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family. |
1373423-53-0 |
DC1036 |
GSK-0660
Featured
GSK-0660 is a selective PPARδ antagonist (IC50 values are 0.155, > 10 and ≥ 10 μM at PPARδ, PPARα and PPARγ respectively). |
1014691-61-2 |
DC11280 |
GSK1016790A
Featured
GSK1016790A is a novel and potent TRPV4 channel agonist. |
942206-85-1 |
DC7140 |
GSK1070916
Featured
GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM; displays >100-fold selectivity against the closely related Aurora A-TPX2 complex(IC50=490 nM). |
942918-07-2 |
DC7042 |
GSK-126
Featured
GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase with Ki value of 0.5 nM. |
1346574-57-9 |
DC7422 |
GSK1292263
Featured
GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes. |
1032823-75-8 |