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Cat. No.	Product Name	Field of Application
DC3161	Prasugrel Featured	A novel platelet inhibitor
DC23841	EW-7195 Featured	A novel potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α.
DC21855	ZINC 39395747 Featured	ZINC 39395747 is a novel potent derivative of propylthiouracil that functions as a cell-active inhibitor of cytochrome b5 reductase 3 (CYB5R3) with IC50 of 9.14 uM.
DC21354	MT47-100 Featured	MT47-100 is a novel compound that exhibits a unique dual functionality as both an allosteric activator and inhibitor of AMP-activated protein kinase (AMPK) complexes, depending on the isoform present. Specifically, MT47-100 acts as a direct activator of AMPK complexes containing the β1 isoform and as a direct inhibitor of AMPK complexes containing the β2 isoform. This isoform-specific modulation of AMPK activity makes MT47-100 a potentially valuable tool for studying the distinct physiological roles of β1- and β2-containing AMPK complexes, as well as a candidate for therapeutic applications targeting AMPK-related pathways.
DC11769	MPO-IN-28 Featured	A novel potent, irreversible Myeloperoxidase (MPO) inhibitor with IC50 of 44 nM.
DC11750	SR-1664 Featured	SR-1664 is a novel potent, non-agonist PPARγ ligand that blocks the Cdk5-mediated phosphorylation in vitro (IC50=80 nM) and in vivo, without the classical agonism.
DC11607	JTZ-951(Enarodustat) Featured	A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
DC22745	SLx-4090 Featured	A novel potent, selective and orally active enterocytic microsomal triglyceride transfer protein (MTP) inhibitor that inhibits only MTP localized to enterocytes with IC50 of 6 nM.
DC20841	BRD6989 Featured	A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex.
DC11827	9-ING-41 Featured	9-ING-41 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor[1]. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK-3β. 9-ING-41 has anticancer activity[2].
DC11904	Olinciguat (IW-1701) Featured	Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.
DC21703	STAT5 inhibitor 17f Featured	A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation.
DC22938	ICA-027243 Featured	A novel potent, selective KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.38 uM..
DC11587	SirReal1 Featured	A novel potent, selective Sirt2 inhibitor with IC50 of 3.745 uM.
DC23672	Gemigliptin Featured	A novel potent, selective, competitive and orally active DPP4 inhibitor with potential for the treatment of type 2 diabetes.
DC20690	ASP 2905 Featured	A novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM.
DC11547	LY-2562175 Featured	LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM.
DC21522	Balixafortide(POL6326) Featured	Balixafortide(POL 6326) is a novel potent, selective, peptidic CXCR4 antagonist that interferes with the tumor-protective microenvironment and sensitizes tumor cells to chemotherapy.
DC22600	HI-TOPK-032 Featured	A novel potent, specific TOPK inhibitor that has no effect on ERK1, JNK1, or p38 kinase activity.
DC22592	Amiselimod hydrochloride (MT-1303 hydrochloride) Featured	A novel prodrug S1P receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators.
DC11916	FD-5180 Featured	A novel protein kinase affinity probe...
DC26112	SLMP53-1 Featured	SLMP53-1 is a novel reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells.
DC21702	SC-99 Featured	A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src.
DC11527	Quilseconazole Featured	A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor.
DC20650	AKI603 Featured	AKI-603 is a novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; t; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration.
DC11954	JP-153 Featured	JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.
DC21039	GATA4-IN-3 Featured	A novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation.
DC11669	CB-002 Featured	CB-002 is a novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.
DC21056	GMI-1271 Featured	A novel specific glycomimetic E-Selectin antagonist with Kd of 0.46 uM, IC50 of 1.75 uM.
DC5893	SCD1 inhibitor Featured	A novel stearoyl-CoA desaturase1 (SCD1) inhibitor.The compound exhibited robust in vivo activity with dose-dependent desaturation index lowering effects.

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