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Cat. No.	Product Name	Field of Application
DC23945	Pyr10 Featured	Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels[1].
DC10646	VPS34 inhibitor(Compound 80) Featured	A novel VPS34 inhibitor.
DC11676	NS15370 Featured	A novel, highly potent positive modulator of Kv7 channels with EC50 of 100 nM (Kv7.2-Kv7.5).
DC21033	Trilaciclib hydrochloride(G1T28) Featured	A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 4 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively.
DC22533	Eleclazine hydrochloride Featured	A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF).
DC20439	LXRβ agonist 17 Featured	LXRβ agonist 17 is a novel, potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα; also exhibits excellent selectivity against other nuclear hormone receptors (>3,000-fold); induces the expression of LXR target genes in vitro and in vivo.
DC11970	KU675 Featured	A novel, second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively.
DC21050	FN1-8 Featured	FN1-8 is a novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM); inhibits non-canonical Gli activation and acts downstream of the canonical Hh pathway; suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo.
DC10533	PKM2 inhibitor(compound 3k) Featured	A novle PKM2 inhibitor inhibitor.
DC23940	NM107 Featured	NM-107, also known as 2'-C-Methylcytidine; 2'-C-MeC; 2-CMC; mCyd ; 2'CMeC; 2CMC, is a a potent and selective anti-viral drug. NM-107 showed activity to inhibit the replication of foot-and-mouth disease virus. NM-107 exerts potent anti-DENV activity in DENV subgenomic RNA replicon and infectious systems, with an IC50 value of 11.2±0.3μM. NM-107 may be a promising compound for the development of direct-acting antivirals against DENV infection.
DC39815	Tafluprost Featured	Tafluprost(AFP-168) is an anti-glaucoma prostaglandin (PG) analog.A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.1,2,3,4 Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency.
DC22989	BMS-204493 Featured	A pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM.
DC23094	TRAP-6 Featured	A PAR1 peptide fragment (residues 42-47) that acts as a PAR1 agonist.
DC22372	Dexpramipexole Featured	A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively.
DC22373	Dexpramipexole dihydrochloride Featured	Dexpramipexole 2Hcl(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.
DC23934	FTI-277 Featured	A peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM.
DC20311	Apraglutide Featured	A peptidic glucagon like peptide 2 (GLP-2) analogue for treatment of type2 diabetes..
DC22782	MDL-72527 Featured	A polyamine oxidase (PAO) inhibitor that inhibits spermine oxidase and N1-acetylpolyamine oxidase with IC50 of 6.1 and 0.02 uM, respectively.
DC20911	Omuralide Featured	A potent 20S proteasome inhibitor with IC50 of 49 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity)..
DC22960	ICA-105574 Featured	A potent and efficacious hERG channel activator steeply potentiates current amplitudes more than 10-fold with EC50 of 0.5 uM.
DC21158	JAK3-IN-2 Featured	A potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM.
DC22627	Trametinib DMSO solvate Featured	A potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
DC23952	GR-79236 Featured	GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals.
DC22498	A-443654 Featured	A potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
DC22584	Mavorixafor(AMD-070) Featured	A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay.
DC22583	AMD-070 hydrochloride(Mavorixafor) Featured	A potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay.
DC22691	MK-4618 Featured	A potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM.
DC22340	Linaclotide Featured	A potent and selective GC-C agonist (Ki=1.23-1.64 nM) that elicits pharmacological effects locally in the gastrointestinal tract.
DC24100	LY2365109 hydrochloride Featured	A potent and selective GlyT1 inhibitor with IC50 of 15.8 nM, displays no activity for GlyT2 (IC50>30 uM).
DC11705	GPR30 inhibitor G1 Featured	A potent and selective GPER/GPR30 agonist with Ki of 11 nM, EC50 of 2 nM.

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