| DC50061 |
Pomalidomide-C2-NH2(E3 ligase Ligand 17)
Featured
|
E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. |
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| DC50062 |
Thalidomide-NH-PEG1-C2-NH2
Featured
|
Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. |
|
| DC50063 |
(S,R,S)-AHPC-C6-NH2
Featured
|
PROTAC building block. |
|
| DC50064 |
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2)
Featured
|
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC. |
|
| DC50065 |
（S,R,S)-AHPC-CO-CI-Br
Featured
|
（S,R,S)-AHPC-CO-CI-Br is a novel protac building block, |
|
| DC50068 |
(S,R,S)-AHPC-Me-C10-NH2
Featured
|
(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 |
|
| DC50069 |
(S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7)
Featured
|
(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. |
|
| DC50070 |
(S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base)
Featured
|
(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs. |
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| DC50071 |
(S,R,S)-AHPC-PEG2-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 6)
Featured
|
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs. |
|
| DC50072 |
(S,R,S)-AHPC-PEG3-NH2 （E3 ligase Ligand-Linker Conjugates 5）
Featured
|
(S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. |
|
| DC50073 |
(S,R,S)-AHPC-PEG3-NH2 hydrochloride（E3 ligase Ligand-Linker Conjugates 5）
Featured
|
(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. |
|
| DC50074 |
(S,R,S)-AHPC-Me-C1-NH2
Featured
|
(S,R,S)-AHPC-Me-C1-NH2 is a novel PROTAC Building block. |
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| DC50075 |
(S,R,S)-AHPC-Me-C2-NH2
Featured
|
(S,R,S)-AHPC-Me-C2-NH2 is a novel PROTAC building block. |
.png)
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| DC50076 |
(S,R,S)-AHPC-Me-C3-NH2
Featured
|
(S,R,S)-AHPC-Me-C3-NH2 is a novel PROTAC building block. |
.png)
|
| DC50077 |
(S,R,S)-AHPC-Me-C4-NH2
Featured
|
(S,R,S)-AHPC-Me-C4-NH2 is a novel PROTACA building block. |
_1.png)
|
| DC50078 |
(S,R,S)-AHPC-Me-C8-NH2
Featured
|
(S,R,S)-AHPC-Me-C8-NH2 is a novel PROTAC building block. |
.png)
|
| DC50079 |
Thalidomide-O-amido-C5-NH2
Featured
|
Thalidomide-O-amido-C5-NH2 is a novel PROTAC building block. |
|
| DC50090 |
SEP-363856 (hydrochloride)
Featured
|
SEP-363856 hydrochloride (SEP-856 hydrochloride), an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 hydrochloride (SEP-856 hydrochloride) has the potential for the study of schizophrenia. |
|
| DC50091 |
Phthalazinone pyrazole
Featured
|
Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). |
|
| DC50092 |
Arginase inhibitor 1
Featured
|
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively. |
|
| DC50093 |
USL-311
Featured
|
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation and decreases proliferation and migration of CXCR4-expressing tumor cells. |
|
| DC50096 |
GW604714X
Featured
|
GW604714X is a novel potent and selective inhibitor of mitochondrial respiration supported by pyruvate. |
|
| DC50098 |
TRPV4 agonist-1
Featured
|
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay. |
|
| DC70007 |
Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine
Featured
|
Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine alters the lifespan of a eukaryotic organism. |
|
| DC70008 |
CLinDMA
Featured
|
CLinDMA, a cationic lipid known to potentially trigger inflammatory responses, is utilized in the synthesis of LNP201. This liposome-based assembly is specifically designed for the systemic delivery of siRNA. |
|
| DC70010 |
98N12-5
Featured
|
98N12-5 is an ionizable cationic lipid. It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs). LNPs containing 98N12-5 and encapsulating proprotein convertase subtilisin kexin type 9 (PCSK9) siRNA selectively accumulate in the liver and reduce total serum cholesterol levels in mice and rats and serum LDL levels in cynomolgus monkeys. |
|
| DC70046 |
MRTX 0902
Featured
|
MRTX0902 is a potent SOS1 inhibitor with an IC50 of 46 nM (WO2021127429A1; Example 12-10). |
|
| DC70063 |
CFI-402257(luvixasertib)
Featured
|
CFI-402257(luvixasertib) is a potent and selective Mps1/TTK kinase inhibitor with Ki of 0.1 nM and cellular Mps1 EC50 of 6.5 nM. |
|
| DC70072 |
ML-241 hydrochloride
Featured
|
ML241 Hcl is a potent, selective and reversible AAA ATPase p97 inhibitor (IC50=100 nM). |
|
| DC70085 |
Nedisertib (Synonyms: Peposertib; M3814)
Featured
|
Nedisertib (M3814, MSC2490484A) is a highly potent, selective, orally bioavailable inhibitor of DNA-PK. |
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