| DC72741 |
BGB 15025
Featured
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BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers. |
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| DC72747 |
Elenestinib
Featured
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Elenestinib (BLU-263) is a potent and orally active tyrosine kinase inhibitor. Elenestinib has the potential for the research of systemic mastocytosis (SM). |
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| DC72750 |
GNE-9822
Featured
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GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma. |
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| DC72751 |
CT52923
Featured
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CT52923 is a selective, orally active platelet-derived growth factor receptor (PDGFR) antagonist. CT52923 also is an ATP-competitive inhibitor. CT52923 can be used for the research variety of pathological diseases, including atherosclerosis, glomerulonephritis, liver cirrhosis, pulmonary fibrosis, and cancer. |
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| DC72756 |
JQAD1
Featured
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JQAD1 is a CRBN-dependent PROTAC that selectively targets EP300 for degradation. JQAD1 suppresses EP300 expression and the H3K27ac modification. JQAD1 induces apoptosis. JQAD1 can be used in research of cancer. |
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| DC72765 |
Evocalcet
Featured
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Evocalcet (KHK7580) is an novel oral calcimimetic agent which acts via allosteric activation of the calcium sensing receptor (CaSR). Evocalcet (0, 20 and 60 nM) dose-dependently increases cytoplasmic [Ca2+] concentrations with an EC50 value of 92.7 nM in hCaR-HEK293 cells. |
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| DC72766 |
PF-07054894
Featured
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PF-07054894 is a potent CCR6 antagonist. PF-07054894 targets G protein-coupled receptor (GPCR). PF-07054894 can be used in research of inflammatory bowel disease. |
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| DC72770 |
Zongertinib
Featured
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Zongertinib is a potent tyrosine kinase inhibitor. Zongertinib can be used as an antineoplastic agent. Zongertinib also has been tested as pHER2 and EGFR inhibitor inhibiting a wide variety of cancers. |
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| DC72773 |
Brigimadlin
Featured
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Brigimadlin is an E3 ubiquitin-protein ligase MDM-2 inhibitor. Brigimadlin serves as an antineoplastic agent. |
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| DC72775 |
iJMJD6
Featured
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iJMJD6(WL12) is an inhibitor of arginine demethylase JMJD6 with an IC50 value of 0.22 μM. |
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| DC72776 |
SD49-7
Featured
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SD49-7 is an inhibitor of histone lysine-specific demethylase 4 (KDM4) with an IC50 of 0.19 µM. |
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| DC72777 |
DS-9300
Featured
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DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC50 value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research. |
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| DC72779 |
RK-701
Featured
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RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC50 value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A. |
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| DC72785 |
TP0597850
Featured
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TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min). |
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| DC72788 |
AZD0095
Featured
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AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). AZD0095 effectively inhibits the tumor growth in NCI-H358 xenograft in combination with Cediranib. |
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| DC72794 |
Zidesamtinib
Featured
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Zidesamtinib (NVL-520) is a potent, selective, orally active and brain-penetrant inhibitor of diverse ROS1 fusions and resistance mutations, with IC50s of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and spares TRK inhibition. Zidesamtinib can be used for the research of cancer. |
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| DC72800 |
PESTAHIVIN
Featured
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PESTAHIVIN is a cell adhesion molecule inhibitor. HUN-7293 selectively inhibits the expression of three cell adhesion molecules (VCAM-1, ICAM-1 and E-selectin) (IC50=1-24 nM). HUN-7293 can be used in the study of inflammatory and autoimmune diseases characterized by overexpression of cell adhesion molecules. |
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| DC60391 |
WEHL-03
Featured
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| DC60392 |
WEHL-04
Featured
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| DC60393 |
T3
Featured
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| DC60394 |
PU-WS13
Featured
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PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM. |
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| DC60395 |
Meclozine
Featured
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Meclozine is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
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| DC60396 |
(S)-SHA 68
Featured
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| DC60397 |
1-Methyl-3-amino-4-cyanopyrazole
Featured
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| DC60398 |
TFMT
Featured
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TFMT (Trifluoromethyl-tubercidin) inhibits methyltransferase 1 (MTr1) through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication. TFMT is active against influenza A virus (IAV) and influenza B virus (IBV) but not hazara virus (HAZV) or Issyk-Kul virus (ISKV). |
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| DC60399 |
DT2216-isomer
Featured
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DT2216-isomer is an isomer of DT2216. Compared to DT-2216, DT2216-isomer has a S-chiral carbon which links to the nitrogen atom of the aniline group. DT2216 is a potent and selective Bcl-xL-specific degrader. DT2216 is highly active against Bcl-xL-dependent T cell lymphomas. DT2216 selectively killed various Bcl-xL-dependent TCL cells including MyLa cells in vitro. In vivo, DT2216 alone was highly effective against MyLa TCL xenografts in mice without causing significant thrombocytopenia or other toxicity. Furthermore, DT2216 combined with ABT199 (a selective Bcl-2 inhibitor) synergistically reduced disease burden and improved survival in a TCL PDX mouse model dependent on both Bcl-2 and Bcl-xL. |
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| DC60400 |
Gramicidin S
Featured
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Gramicidin S is an anttiboitics. Gramicidin S reduces the cell number of planktonic cells within 20-40 min at a concentration of 40-80 μg/mL. Gramicidin S kills the cells of pre-grown biofilms at concentrations of 100-200 μg/mL, such that no re-growth is possible. The translocation of the peptide into the cell interior and its complexation with intracellular nucleotides, including the alarmon ppGpp, can explain its anti-biofilm effect. The successful treatment of persistently infected root canals of two volunteers confirms the high effectiveness of GS. The broad Gramicidin S activity towards resistant, biofilm-forming E. faecalis suggests its applications for approval in root canal medication. |
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| DC60401 |
DL-AP-3
Featured
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DL-AP-3, or AP-3 is a Potent metabotropic glutamate receptor antagonist.
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| DC60402 |
Dov-Val-Dil-OH
Featured
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Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin. |
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| DC60403 |
Bacteriopheophytin
Featured
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Bacteriopheophytin, also known as Bacteriopheophytin a, is a Pigment which is the degradation product of bacteriochlorophyll.
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