| DC60401 |
DL-AP-3
Featured
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DL-AP-3, or AP-3 is a Potent metabotropic glutamate receptor antagonist.
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| DC60402 |
Dov-Val-Dil-OH
Featured
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Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin. |
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| DC60403 |
Bacteriopheophytin
Featured
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Bacteriopheophytin, also known as Bacteriopheophytin a, is a Pigment which is the degradation product of bacteriochlorophyll.
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| DC83220 |
ALC-0315 analgous-1
Featured
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ALC-0315 analgous-1 is an ethanolamine ionizable lipid with both ester bonds located adjacent to C8 relative to the amine head. The introduction of ester linkages can improve the clearance of the lipid in the liver. This compound is analgous to ALC-0315. |
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| DC60411 |
Boc-Val-Cit-PAB-PNP
Featured
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Boc-Val-Cit-PAB-PNP is useful and cleavable linker for ADC (antibody drug conjugate) synthesis. |
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| DC60412 |
VUN74640
Featured
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VUN74640, also known as CCR6 antagonist 1, is a CCR6 antagonist. VUN74640 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs). This product has no formal name at the moment. |
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| DC60413 |
Vc-MMAF
Featured
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MC-VC-PAB-MMAF, also known as MC-Val-Cit-PAB-MMAF and Vc-MMAF, is a MMAF (Monomethylauristatin F) derivative with a reactive linker have a maleimido functional group in the end. MC-VC-PAB-MMAF is a useful compound to make MMAF antibody drug conjugates for cancer treatment. MMAF is a potent tubulin polymerization inhibitor with antitumor activity. |
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| DC60414 |
WAY-111543
Featured
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WAY-111543 is a bioactive chemical. |
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| DC60415 |
MitoBlock-6
Featured
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MitoBlock-6 is an Augmenter of liver regeneration (ALR) inhibitor. MitoBloCK-6 attenuated the import of Erv1 substrates into yeast mitochondria and inhibited oxidation of Tim13 and Cmc1 in in vitro reconstitution assays. |
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| DC60416 |
SUN59716
Featured
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SUN59716 is a key intermediate for chemical synthesis of cenobamate. This product has no formal name at the moment. |
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| DC60417 |
EN106
Featured
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EN106 is a potent inhibitor of FEMIB. EN106 targets FEM1B, an E3 ligase recently discovered as the critical component of the cellular response to reductive stress. By targeting C186 in FEM1B, EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1. |
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| DC60421 |
DC-6-14
Featured
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DC-6-14 is a cationic lipid that can be used for drug delivery, gene transfection and vaccine delivery. DC-6-14 may be used for research into in vitro and in vivo nucleic acid and protein delivery. Reagent grade, for research use only.
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| DC60433 |
DOBAQ
Featured
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DOBAQ, N-(4-carboxybenzyl)-N,N-dimethyl-2,3-bis(oleoyloxy)propan-1-aminium, is a cationic lipids with a quaternary amine and unsaturated hydrocarbon chains. DOBAQ also serves as a pH-sensitive transfection reagent. Reagent grade, for research use only. |
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| DC60434 |
Bendamustine HCL Monohydrate
Featured
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| DC60435 |
Belumosudil mesylate
Featured
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Belumosudil, also known as KD-025 and WHO11343, is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 µM, respectively). Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. |
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| DC60436 |
Eperison Hydrochloride
Featured
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Eperisone hydrochloride is a compound used in the treatment of musculoskeletal disorders as a muscle relaxant via blocking of calcium channels.
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| DC60437 |
Tizanidine
Featured
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Tizanidine is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. |
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| DC84101 |
Arcturus lipid 2 analog (ATX0114analog)
Featured
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Arcturus lipid 2 analog (ATX0114analog, Lipid 2,2 (9,9) 4C CH3) is an analog of Arcturus lipid 2((Lipid 2,2 (8,8) 4C CH3)) with chain adjusted to C9 instead of C8. |
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| DC60438 |
17S-FD-895
Featured
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17S-FD-895 is a tubulin polymerization inhibitor with marked antitumor activities. |
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| DC60439 |
XC-DAPOL-CPBA
Featured
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| DC60440 |
2,3-Dimethyl-1,3,8-triazaspiro[4.5]dec-1-en-4-one hydrochloride
Featured
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| DC65001 |
4A3-Cit
Featured
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4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs). To investigate the role of unsaturated lipid tails in iLNPs, the
nucleophilic amines were added to ester-based linkers, followed
by Michael’s addition to the thiols to construct a library of 91
amino ionizable lipids. Such ionizable lipids were composed
of an ionizable tertiary amine core, an ester-based degradable
linker, and an alkylthiol tail periphery. Through in vitro
and in vivo screening, the iLNPs with 4A3 core and citronellolbased
(Cit) periphery can significantly increase endosome escape
and delivery efficiency of mRNA, leading to 18-fold increase in
protein expression compared with iLNPs without Cit periphery.
Furthermore, the delivery efficiency of mRNA may be associated
with the location/configuration of the unsaturated bond(s) in
lipids. Although lipids with Cit periphery showed excellent
membrane fusion ability to facilitate endosome escape, the
fusion mechanism needs to be further clarified. |
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| DC65005 |
Diuron
Featured
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Diuron is a phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (2,500 ppm, dietary) increases the incidence of urinary bladder urothelial carcinomas in male and female mice by 73 and 27%, respectively. |
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| DC65006 |
Metasilicic acid
Featured
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| DC65007 |
A2
Featured
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| DC65008 |
tributylammonium pyrophosphate
Featured
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| DC65010 |
m-PEG11-alcohol
Featured
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m-PEG11-alcohol is a PEG derivative containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. |
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| DC65011 |
m-PEG3-CH2COOH
Featured
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m-PEG3-CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs. |
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| DC65012 |
m-PEG4-CH2COOH
Featured
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m-PEG4-CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs. |
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| DC65013 |
m-PEG6-CH2COOH
Featured
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m-PEG6-O-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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