Novel VISTA (V-domain immunoglobulin suppressor of T-cell activation) agonist

Potent and specific pan-PIM inhibitor, inhibiting proliferation of several AML cell lines, showing dual antitumoral and bone antiresorptive effects

Novel Potent Allosteric Activator for Ferroptosis Regulator Glutathione Peroxidase 4 (GPX4)

The first-in-class dual inhibitor of ENL (Kd = 754 ± 45 nM) and its paralog AF9 (Kd = 523 ± 53 nM)

Novel DNA polymerase inhibitor, inhibiting DNA replication in assays to assess global DNA synthesis or single-molecule bases by DNA fiber fluorography

Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.

Novel inhibitor of MuRF1, attenuating skeletal muscle atrophy and dysfunction in cardiac cachexia

Furimazine is an imidazopyrazinone substrate. NanoLuc (Nluc) paired with Furimazine produced 2.5 million-fold brighter luminescence in mammalian cells relative to Oluc-19 with Coelenterazine.

Novel fluorescent substrate for both the serotonin transporter and the vesicular monoamine transporter 2 (VMAT2)

RO6806051 (compound12) is a potent dual fatty acid binding protein 4 and 5 (FABP4 and FABP5) inhibitor with good selectivity and absorption, distribution, metabolism and excretion (eADME) properties.

Novel TDP-43 ligand, binding to TDP-43's RRM1 and RRM2 domains, partially disrupting TDP-43's interaction with the hexanucleotide RNA repeat of the disease-linked c9orf72 gene, improving larval turning, an assay measuring neuromuscular coordination and st

Novel modulator of Hydra head regeneration, inducing a homeotic transformation in Hydra

Novel selective uncompetitive inhibitor of DNA ligase I (LigI)

Novel autophagy inhibitor, selectively targeting cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A), and directly competing with cholesterol binding to the GRAMD1A StART domain

DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents.

Highly specific allosteric activator for the tumor-specific isoform of human pyruvate kinase M2 isoform (PKM2)

Novel Selective Histone Deacetylase 6 (HDAC6) Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models

Natural inducer of apoptosis via Akt/NF-κB signaling suppression

Novel potent agonist of HTL/KAI2, stimulating activity for Arabidopsis seed germination

ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression.

Selective blocker of the Aquaporin-1 ion channel conductance, slowing cancer cell migration

CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively).