Lirafugratinib|CAS 2549174-42-5|DC Chemicals

Cas No.:	2549174-42-5
Chemical Name:	Fgfr2-IN-3
Synonyms:	Lirafugratinib;Lirafugratinib [USAN];7HY6IMH87S;FGFR2-IN-3;RLY4008;2-Propenamide, N-(4-(4-amino-5-(3-fluoro-4-((4-methyl-2-pyrimidinyl)oxy)phenyl)-7-methyl-7H-pyrrolo(2,3-d)pyrimidin-6-yl)phenyl)-2-methyl-;2-Propenamide, N-[4-[4-amino-5-[3-fluoro-4-[(4-methyl-2-pyrimidinyl)oxy]phenyl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methyl-;NSC842116;WHO 12482;N-(4-(4-amino-5-(3-fluoro-4-((4-methylpy;RLY-4008
SMILES:	CN1C2=NC=NC(N)=C2C(C2C=CC(OC3=NC=CC(C)=N3)=C(F)C=2)=C1C1C=CC(NC(=O)C(=C)C)=CC=1
Formula:	C₂₈H₂₄FN₇O₂
M.Wt:	509.534268379211
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Lirafugratinib (RLY-4008) is an orally active and selective inhibitor of FGFR2.
Target:	FGFR2[1]
References:	[1]. [1] Lescarbeau, Andre, et al. Preparation of substituted pyrrolopyrimidines as FGFR inhibitors and methods of making and using the same. WO2022109577.

MSDS

Cat. No.	Product name	Field of application
DC72885	Lirafugratinib	Lirafugratinib (RLY-4008) is an orally active and selective inhibitor of FGFR2.
DC40209	ZUN97585(FGFR1/DDR2 inhibitor 1)	FGFR1/DDR2 inhibitor 1 is an orally active inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM and 3.2 nM, respectively. Antitumor activity.
DC10641	PRN1371	PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively.
DC10128	FGF401( Roblitinib)	FGF401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity.
DC10559	Derazantinib (ARQ 087)	Derazantinib (Derazantinib) is an ATP competitive tyrosine kinase inhibitor; exhibits potent activity against FGFR1-3 chondrocytes with IC50s of 4.5, 1.8, and 4.5 nM, respectively.