| DC65482 |
Amyloid beta-peptide(25-35)
Featured
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β-Amyloid (25-35) (Amyloid beta-peptide (25-35), Aβ25-35, β-Amyloid peptide (25-35)) , a sequence GSNKGAIIGLM, is a highly toxic synthetic derivative of Amyloid beta-peptide (Aβ-peptides) which forms fibrillary aggregates. β-Amyloid (25-35) is involved in the pathogenesis of Alzheimer's disease. |
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| DC65483 |
SI-2 (hydrochloride)
Featured
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SI-2 hydrochloride (EPH 116 hydrochloride) is a highly promising SRC-3 SMI: SRC-3 inhibitor (PPI), with IC50 values of 3-20 nM for breast cancer cell death. SI-2 hydrochloride (EPH 116 hydrochloride) has a much improved toxicity and pharmacokinetic profile, with acceptable oral availability[1]. |
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| DC65484 |
WAY-639889
Featured
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WAY-639889 is a bioactive compound relative to neuropeptide Y-5. |
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| DC65486 |
ZW290
Featured
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ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. ZW290 increases the expression of uncoupling Protein 1 (UCP1) protein and inhibits ATP synthesis in BAT. |
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| DC65485 |
CP-226269
Featured
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CP 226269 is a potent dopamine D4 receptor agonist that induces calcium flux with EC50 of 32.0 nM. CP 226269 can be used in the research of schizophrenia and other related diseases. |
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| DC65487 |
SRD5A1-IN-1
Featured
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SRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC50 of 1.44 µM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression[1]. |
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| DC65489 |
CRCD2
Featured
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CRCD2 is an NT5C2 (cytosolic 5’ nucleotidase II) inhibitor with a kd of 70.9 μM. It enhances the cytotoxic effects of 6-MP and effectively reverses thiopurine resistance mediated by genetic and non-genetic mechanisms of NT5C2 activation in ALL. |
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| DC65490 |
Colestipol hydrochloride
Featured
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Colestipol hydrochloride, a salt form of Colestipol, is a high-molecular-weight, insoluble, granular copolymer of tetraethylenepentamine and epichlorohydrin. It functions as an anion-exchange and resin-sequestering agent. Colestipol hydrochloride reduces cholesterol levels without affecting triglycerides. |
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| DC65491 |
TMRM Perchlorate
Featured
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TMRM Perchlorate is a cell-permeant cationic lipophilic red fluorescent dye (λex=530 nm, λem=592 nm). |
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| DC65492 |
Copper sulfate
Featured
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Cupric sulfate (Copper(II) sulfate) is a salt formed by treating cupric oxide with sulfuric acid. Cupric sulfate is a lewis acid catalyst commonly used to promote acid-catalyzed organic transformations. |
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| DC65493 |
SIRT5 inhibitor 5
Featured
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SIRT5 inhibitor 5 is a potent SIRT5 inhibitor with an IC50 value of 0.21 µM. |
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| DC65494 |
HDAC-IN-57
Featured
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HDAC-IN-57 is an orally active inhibitor of histone deacetylases (HDAC), with IC50s of 2.07 nM, 4.71 nM, 2.4 nM and 107 nM for HDAC1, HDAC2, HDAC6, HDAC8, respectively. HDAC-IN-57 can inhibits LSD1, with IC50 of 1.34 μΜ. HDAC-IN-57 induces apoptosis, and has anti-tumor activity[1]. |
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| DC65495 |
PYZ18
Featured
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PYZ18 is a selective COX-2 inhibitor with an IC50 of 7.07 μM. PYZ18 is the best lead compound for COX-2 inhibitors. PYZ18 has anti-inflammatory and other biological properties[1]. |
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| DC65496 |
Gcase activator 2
Featured
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Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM). Gcase activator 2 induces GCase dimerizatio (both K-type and V-type). And Gcase activator 2 has low metabolic clearance in human and mouse[1]. |
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| DC65497 |
CYP4Z1-IN-1
Featured
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CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo[1]. |
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| DC65498 |
hCAII-IN-9
Featured
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hCAII-IN-9 is a potent carbonic anhydrase inhibitor |
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| DC65499 |
hCAII-IN-8
Featured
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hCAII-IN-8, an amide, is a highly selective carbonic anhydrase (CA) inhibitor with an IC50 value of 0.18 μM against hCA II[1]. |
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| DC65500 |
GW6340
Featured
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GW6340 is an intestinal-specific LXR agonist. |
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| DC65501 |
GFP16
Featured
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GFP16 is a low affinity antiprion compound. |
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| DC65502 |
BI-2865
Featured
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BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. Inhibition of downstream signalling and proliferation was restricted to cancer cells harbouring mutant KRAS, and drug treatment suppressed KRAS mutant tumour growth in mice, without having a detrimental effect on animal weight. |
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| DC65503 |
KIF18A-IN-3
Featured
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KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer[1]. |
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| DC65504 |
Skp2 inhibitor 1
Featured
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Skp2 inhibitor 1 (compound 14i) is a potent and selective Skp2 inhibitor |
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| DC65505 |
PRMT6-IN-3
Featured
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PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor |
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| DC65506 |
PARP10-IN-2
Featured
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PARP10-IN-2 is a potent mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC50s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively[1]. |
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| DC65507 |
PHGDH-IN-3
Featured
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PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC50 value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer[1]. |
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| DC65508 |
MyD88-IN-1
Featured
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MyD88-IN-1 is a potent MyD88 inhibitor. |
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| DC65509 |
TNF-α-IN-9
Featured
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TNF-α-IN-9 (compound 48) is a analog of NDM-1 inhibitor-3
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| DC65510 |
Antibacterial agent 132
Featured
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Antibacterial agent 132 has anticandidal effects against C. parapsilosis (ATCC 22019) and C. krusei (ATCC 6258) |
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| DC65511 |
Antibacterial agent 133
Featured
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Antibacterial agent 133 (4l) is an antimicrobial agent |
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| DC65512 |
WDR5-IN-6
Featured
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WDR5-IN-6 is a WDR5 inhibitor. |
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