Novel pendrin inhibitor, attenuating airway hyperresponsiveness and mucin expression in experimental murine asthma

SP-13786(UAMC-1110) is a Novel potent and selective inhibitor of fibroblast activation protein (FAP), displaying low nanomolar inhibitory potency and high selectivity against the related dipeptidyl peptidases (DPPs) DPPIV, DPP9, DPPII, and prolyl oligopeptidase (PREP)

A sphingosine 1-phosphate (S1PR) receptor agonist

Novel suppressor of plant immune responses

Novel potent FKBP12 ligand

Novel potent and cell-active PARG inhibitor, selectively killing BRCA-mutant and PARP inhibitor-resistant cancer cells

Novel potent and selective antagonist of human Complement C3a receptor

Novel inhibitor of PKM2-regulated signaling, suppressing non-glycolytic PKM2-regulated signaling in cancer cells

AZ617 is a potent TLR4 agonist.

BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus T

HaloPROTAC3 is a degrader of HaloTag fusion proteins.

Novel FAK activator, promoting human intestinal epithelial monolayer wound closure and mouse ulcer healing

Novel antibiotic against a unique tRNA-mediated regulation of transcription in Gram-positive bacteria, significantly inhibiting in vivo transcription of glycyl-tRNA synthetase mRNA, also inhibiting in vivo translation of the S. aureus threonyl-tRNA synthe

Novel Inhibitor of StearoylCoA Desaturase-1 (SCD1)

6R-FR054 is a 6R-isomer of FR054. FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.

CGS-15943| is a highly potent, non-selective adenosine receptor antagonist.

CYM51010 is a biased ligand of μ-opioid receptor – δ-opioid receptor heterodimers. CYM51010 exhibits anti-nociceptive activity similar to morphine, but with a decreased levels of tolerance development and withdrawal symptoms.

Aurachin D is an antibiotic. Aurachin D inhibits Gram-positive bacteria and a few funguses. Aurachin D blocks NADH oxidation in beef heart submitochondrial particles.

UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines[1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli[2].

4-Allylcatechol (4-Allylpyrocatechol, Hydroxychavicol) is an intermediate to synthetic safrole.

Inhibitor of placental alkaline phosphatase (PLAP)

Potent and selective EP4 antagonist