| DC89083 |
Pacritinib citrate
Featured
|
Pacritinib Citrate is the citrate salt form of pacritinib, an orally bioavailable inhibitor of Janus kinase 2 (JAK2). |
|
| DC65567 |
ABBV-CLS-484
Featured
|
Osunprotafib (ABBV-CLS-484) is a potent PTPN1 and PTPN2 inhibitor with subnanomolar activity. Osunprotafib has antitumor activity, enhances the immune response and increases the sensitivity of tumors to immune-mediated killing. |
|
| DC60490 |
icFSP1
Featured
|
icFSP1 is a compound class of 3-phenylquinazolinones. icFSP1, unlike iFSP1, is the first described on-target FSP1 inhibitor, does not competitively inhibit FSP1 enzyme activity, but instead triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation before ferroptosis induction, in synergism with GPX4 inhibition. |
|
| DC65569 |
Eg5-IN-1
Featured
|
Eg5-IN-1 (compound 6c) is a potent kinesin family motor protein (Eg5) inhibitor |
|
| DC65570 |
Tubulin inhibitor 35
Featured
|
Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I and tubulin polymerization. |
|
| DC65571 |
FY-21
Featured
|
FY-21 is a selective inhibitor of LSD1. |
|
| DC65572 |
Anti-inflammatory agent 51
Featured
|
Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. |
|
| DC65573 |
WES-1
Featured
|
WES-1 (Compound 8g) is an inhibitor of carbonic anhydrase IX (Ki: 55.9 μM). |
|
| DC65574 |
Anti-NASH agent 1
Featured
|
Anti-NASH agent 1 (compound 3d)，a derivative of Elafibranor (HY-16737)，is a potent agonist of PPAR-α/δ. |
|
| DC65575 |
17β-HSD10-IN-2
Featured
|
17β-HSD10-IN-2 (compound 11) is a benzothiazolylurea-based inhibitor.
|
|
| DC65576 |
17β-HSD10-IN-1
Featured
|
17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects. |
|
| DC65577 |
P-Gb-In-1
Featured
|
P-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. |
|
| DC65578 |
ROS inducer 1
Featured
|
ROS inducer 1 (compound I29) is a fungicide, with EC50 against Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo), and Pseudomonas syringae pv. actinidiae (Psa) |
|
| DC65579 |
h-NTPDase8-IN-1
Featured
|
h-NTPDase8-IN-1 (compound 2d) is a sulfamoyl-benzamides based and selective inhibitor for h-NTPDases8 |
|
| DC65580 |
AD-186
Featured
|
AD186 is a potent and selective S1R agonist |
|
| DC65581 |
AP-C2
Featured
|
AP-C2 is a potent guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor. |
|
| DC65582 |
Cbl-b-IN-5
Featured
|
Cbl-b-IN-5 (compound 6) is a Cbl-b inhibitor. |
|
| DC65583 |
Nurr1 agonist 2
Featured
|
Nurr1 agonist 3 (Compound 7) is a Nurr1 agonist. |
|
| DC65584 |
Antitumor agent-93
Featured
|
Antitumor agent-93 (compound 7D) is an anticancer agent. |
|
| DC65585 |
Sotuletinib dihydrochloride
Featured
|
Sotuletinib, also known as BLZ945, is a potent and selective CSF-1R kinase inhibitor. BLZ945 showed effects of CSF1R inhibition on other tumor-infiltrating immune cells. BLZ945 attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. BLZ945 decreases the growth of malignant cells in the mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis. BLZ945 prevents tumor progression in the keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis. |
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| DC65586 |
B-Raf IN 15
Featured
|
B-Raf IN 15 (Compound 7) is a BRAF inhibitor. |
|
| DC65587 |
ARC7
Featured
|
ARC7 can act as a probe for secondary metabolism in S. coelicolor. |
|
| DC65588 |
5-LOX-IN-2
Featured
|
5-LOX-IN-2 is an inhibitor of 5-lipoxygenase (5-LOX). |
|
| DC65589 |
AKT-IN-18
Featured
|
AKT-IN-18, an inhibitor of Akt, inhibits Akt. |
|
| DC65590 |
Antitumor agent-113
Featured
|
Antitumor agent-113 shows cytotoxic effects on A549 cells. |
|
| DC65595 |
Ethidium bromide
Featured
|
Ethidium bromide is an intercalating agent commonly used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for techniques such as agarose gel electrophoresis. |
|
| DC65596 |
GDC-0068 (dihydrochloride)
Featured
|
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. |
|
| DC65597 |
T807
Featured
|
T807 a novel tau positron emission tomography (PET) tracer. |
|
| DC65598 |
2-Chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
Featured
|
|
|
| DC65599 |
E3 ligase Ligand-Linker Conjugates 3
Featured
|
E3 ligase Ligand-Linker Conjugates 3 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
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