DC11420 |
AS-1517499
Featured
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AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM. |
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DC10086 |
AS1842856
Featured
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AS1842856 is a potent and cell-permeable Foxo1 inhibitor with an IC50 of 30 nM. |
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DC3112 |
AS-252424
Featured
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AS-252424 is a novel, potent and selective inhibitor of PI3Kγ with IC50 of 33 nM. |
|
DC20035 |
AS2717638
Featured
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AS2717638 is an oral active lysophosphatidic acid receptor 5 (LPA5) antagonist in rodents. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia. |
|
DC11460 |
AS604850
Featured
|
AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα. |
|
DC11407 |
Asapiprant(BGE-175)
Featured
|
Asapiprant (BGE-175) is a potent and specific antagonist of human PGD2/PTGDR signaling with Ki of 0.44 nM. BGE-175 is currently in a Phase 2 clinical trial to test whether it can prevent disease progression and mortality in older patients hospitalized wit |
|
DC20622 |
Asciminib
Featured
|
Asciminib (ABL-001) is a potent and selective allosteric ABL1 inhibitor with IC50 of 0.25 nM in BCR–ABL1-transformed BaF3 cells. |
|
DC1049 |
Ascomycin (Immunomycin,FK-520)
Featured
|
Ascomycin is an analog of tacrolimus with immunosuppressive, neurotrophic and antifungal activities. |
|
DC10704 |
Asimadoline (EMD-61753)
Featured
|
Asimadoline (EMD-61753) is a drug which acts as a peripherally selective κ-opioid receptor (KOR) agonist. |
|
DC10781 |
ASK1-IN-1
Featured
|
ASK1-IN-1 is an apoptosis signal regulating kinase 1 (ASK1) inhibitor extracted from patent WO2016025474A1, Compound 4. |
|
DC21100 |
Gusacitinib (ASN-002)
Featured
|
ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5-46 nM in biochemical assays. |
|
DC10558 |
ASP 7663
Featured
|
ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). |
|
DC7359 |
Asp-3026
Featured
|
ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. |
|
DC20218 |
ASP5878
Featured
|
ASP5878 is a selective FGFR inhibitor, to treat FGFR3-dependent urothelial cancer with or without chemoresistance. |
|
DC11174 |
ASP7657
Featured
|
ASP7657 (ASP-7657) is a potent, selective, orally active prostaglandin EP4 receptor antagonist with Ki values of 6.02 nM and 2.21 nM for rat and human EP4 receptors, resepctively. |
|
DC10588 |
ASP-9521
Featured
|
ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3. |
|
DC11163 |
AST-3424
Featured
|
AST-3424 (OBI-3424, TH-3424) is a first-in-class, novel prodrug that selectively targets cancers overexpressing the enzyme AKR1C3, OBI-3424 is a highly selective prodrug that is converted by AKR1C3 to a DNA alkylating agent. |
|
DC8641 |
Astragaloside A
Featured
|
Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. |
|
DC11447 |
Astragaloside IV
Featured
|
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. |
|
DC20695 |
ASTX660(Tolinapant)
Featured
|
ASTX660 is a novel potent IAP antagonist that targets the BIR3 domain of cIAP1/2 and XIAP with IC50 of 12 nM and <40 nM. |
|
DC7361 |
Asunaprevir
Featured
|
Asunaprevir (BMS-650032) is a potent hepatitis C virus (HCV) NS3 protease inhibitor. |
|
DC20080 |
AT-1002
Featured
|
AT-1002, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer. |
|
DC26065 |
AT-127
Featured
|
AT-127 is a novel potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist with Ki of 1.18 nM. |
|
DC20699 |
AT-130
Featured
|
AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM. |
|
DC7362 |
AT13148
Featured
|
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity; AKT, p70S6K, PKA, ROCK, and SGK inhibitor. |
|
DC8167 |
Onalespib(AT13387,ATI13387X)
Featured
|
AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. |
|
DC7363 |
AT-406
Featured
|
AT-406 (formerly known as SM-406) is an orally bioavailable potent IAP (inhibitor of apoptosis protein) of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. |
|
DC7364 |
AT-56
Featured
|
AT-56 is a selective, competitive, and highly bioavailable inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) with a Ki value of 75 µM. |
|
DC9676 |
AT7519
Featured
|
AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM; less potent to CDK3 and little active to CDK7. |
|
DC1025 |
AT7519 HCL
Featured
|
AT7519 is a novel multi-CDK inhibitor for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDK4/Cyclin D1, CDK5/p35 and CDK6/Cyclin D3 with IC50 of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM, respectively. |
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