| DC7922 |
APY0201
Featured
|
APY0201 is a potent, highly selective PIKfyve kinase inhibitor. |
|
| DC7358 |
APY29
Featured
|
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity. |
|
| DC8764 |
AR 231453
Featured
|
AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent. |
|
| DC10135 |
AR-7
Featured
|
AR7 is a retinoic acid receptor α (RARα) antagonist. |
|
| DC22493 |
ARA-290(Cibinetide)
Featured
|
ARA-290 (Cibinetide) is a non-erythropoietic erythropoietin (EPO) derivative. |
|
| DC8888 |
Ara-G
Featured
|
Ara-G (9-β-D-Arabinofuranosyl guanine) is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic. |
|
| DCAPI1051 |
Arbidol HCl (Umifenovir)
Featured
|
Umifenovir is currently being investigated as a potential treatment and prophylactic agent for COVID-19 caused by SARS-CoV2 infections in combination with both currently available and investigational HIV therapies. Arbidol hydrochloride (Umifenovir hydroc |
|
| DC20265 |
Arctigenin
Featured
|
Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, |
|
| DC9659 |
Arctiin(NSC 315527)
Featured
|
Arctiin, a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis. |
|
| DCAPI1329 |
Argatroban
Featured
|
Argatroban |
|
| DC8841 |
Argatroban monohydrate
Featured
|
Argatroban monohydrate is a direct, selective thrombin inhibitor. |
|
| DC9487 |
Arg-Gly-Asp-Ser
Featured
|
Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS |
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|
| DC9645 |
(+)-Arglabin
Featured
|
Arglabin is a sesquiterpene gamma-lactone is isolated from Artemisia glabella; anticancer natural compound. |
|
| DC10110 |
ARM390 Hydrochloride
Featured
|
ARM390 is a non-peptidic, low-internalizing δ-selective opioid receptor agonist. |
|
| DC9345 |
ARN2966(2-PMAP)
Featured
|
ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. |
|
| DC10824 |
ARN-3236
Featured
|
ARN-3236 is potent, orally active and selective SIK2 inhibitor. ARN-3236 inhibited the growth of 10 ovarian cancer cell lines at an IC50 of 0.8 to 2.6 μmol/L. |
|
| DC7064 |
Apalutamide（ARN509）
Featured
|
ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment. |
|
| DC9972 |
ARQ-092(Miransertib)
Featured
|
ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3). |
|
| DC7820 |
ARQ 621
Featured
|
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1. |
|
| DC10975 |
ARQ-531
Featured
|
ARQ-531 is a potent, reversible, orally available inhibitor of both wild type and C481S-mutant BTK kinase with IC50 of 0.85 and 0.39 nM, |
|
| DC8181 |
Filanesib(ARRY-520)
Featured
|
ARRY-520 is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM. |
|
| DC10738 |
ARS-1323
Featured
|
ARS-1323 is a novel inhibitor of mutant K-ras G12C. |
|
| DC10725 |
ARS-1620
Featured
|
ARS-1620 is a covalent compound with high potency and selectivity for KRAS-G12C. |
|
| DC12031 |
ARS-1630
Featured
|
ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound.. |
|
| DC8816 |
ARS-853
Featured
|
ARS-853 is a selective, covalent inhibitor of KRAS-G12C that inhibits mutant KRAS driven signaling by binding to the GDP bound oncoprotein and preventing activation. |
|
| DC10334 |
ARV-771
Featured
|
ARV-771 is a potent bromodomain and extra-terminal (BET) proteins degrader with Kd values of 4.7, 7.6, 7.6 nM against bromodomain 2, 3 and 4, respectively. |
|
| DC12024 |
ARV-825
Featured
|
ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively. |
|
| DC8256 |
AS 602801(Bentamapimod)
Featured
|
AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK. |
|
| DC9840 |
AS-8351
Featured
|
AS 8351 induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409. |
|
| DC22001 |
AS-1269574
Featured
|
AS-1269574 is a selective, orally available GPR119 agonist with EC50 of 2.5 uM in cell-based cAMP assays. |
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