| DC65873 |
Benzamide
Featured
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Benzamide is a small molecule Magmas inhibitor (SMMI). Magmas is mitochondria associated，granulocyte-macrophage colony stimulating factor signaling molecule，as well as a GM-CSF inducible gene in myeloid cells. Magmas-IN-1 inhibits Magmas and modulates mitochondrial function. Magmas-IN-1 also inhibits proliferation in yeast at 4 μM. |
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| DC65874 |
AKOS037652256
Featured
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| DC65875 |
Benzyl Benzodithioate
Featured
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| DC65876 |
VT-105
Featured
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VT-105 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT105 is a more soluble analog of VT104. |
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| DC65877 |
ST33777
Featured
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| DC65878 |
ST-33447
Featured
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| DC65879 |
AP1189 acetate
Featured
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AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ∼3-fold. |
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| DC65880 |
HaloPROTAC-E
Featured
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HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14) and no other proteins were significantly degraded. |
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| DC65881 |
Afabicin
Featured
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Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono, an enoyl-acyl carrier protein reductase (FabI) inhibitor, and is a first-in-class antibiotic with a novel mode of action to specifically target fatty acid synthesis in Staphylococcus spp. |
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| DC65882 |
Methyl 2-Formyl-1H-Pyrrole-3-Carboxylate
Featured
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| DC65883 |
3,5-Dichloro-6-iodopyrazolo[1,5-a]pyrimidine
Featured
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| DC65884 |
CCR2-RA
Featured
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| DC65885 |
Stilbamidine dihydrochloride
Featured
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Stilbamidine dihydrochloride is a blocker of neuromuscular transmission and axonal conduction. It is used to study the distribution of the drug in the organs and tissues of rats following intravenous injection. |
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| DC65886 |
MCU-i11
Featured
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MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth. |
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| DC65888 |
2,4,6-Triisopropyl-m-phenylene diisocyanate
Featured
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| DC65889 |
3-Oxa-1-azaspiro[4.5]decane-2,4-dione
Featured
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| DC65890 |
5,5-Difluoro-5a-methyl-1H,4H,4aH,5H,5aH,6H-cyclopropa[f]indazole-3-carboxylic acid
Featured
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| DC65891 |
GI 181771
Featured
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GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity. |
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| DC65892 |
Cyclopropyl-prop-2-ynyl-amine
Featured
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| DC65893 |
Pyrithione
Featured
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Pyrithione, a Transition metal complexe, is a zinc ionophore that causes increased zinc levels within mammalian cells. Pyrithione has potent bactericidal and anti-fungal activity. |
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| DC65894 |
3-bromo-2-(2-hydroxyethyl)thiophene
Featured
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| DC65895 |
5-Acetyl-2-bromobenzaldehyde
Featured
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| DC65896 |
PSB-15160
Featured
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| DC65897 |
SLU-PP-1072
Featured
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SLU-PP-1072 is a novel Selective ERRα/γ Inverse Agonist, Inhibiting the Warburg Effect and Inducing Apoptosis in Prostate Cancer Cells. |
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| DC65898 |
LMTK3 inibitor C28
Featured
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LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM. |
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| DC60559 |
PT-179
Featured
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PT-179 is a new orthogonal immunomodulatory drug (IMiD) derivative that binds CRBN but does not induce degradation of off-target proteins. PT-179 potently degrades proteins fused to SD40 at either the N or C terminus. |
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| DC65899 |
Des-iPr-TAS-116
Featured
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| DC65900 |
1-Piperidinecarboxylic acid, 4-bromo-3-oxo-, 1,1-dimethylethyl ester
Featured
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| DC65901 |
PSB-1901
Featured
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PSB-1901 is a potent A2B adenosine receptor (A2BAR) antagonist with Kis of 0.0835 nM and 0.131 nM for human and mouse A2BARs respectively. PSB-1901 can be used for the research of cancer. |
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| DC65902 |
2-Amino-8-oxononanoic acid HCl
Featured
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2-Amino-8-oxononanoic acid HCl is a biochemical |
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