| DC65812 |
ASP3082
Featured
|
a KRASG12D degrader for the treatment of solid tumors. |
|
| DC65813 |
FHD-609
Featured
|
a BRD9 degrader for treating synovial sarcoma. |
|
| DC65814 |
GT-20029
Featured
|
a topical AR degrader for the treatment of acne vulgaris. |
|
| DC65815 |
20-HETE inhibitor-1
Featured
|
20-HETE inhibitor-1 (comp 83) is a 20-HETE formation inhibitor |
|
| DC65816 |
APG-2575 (lisaftoclax)
Featured
|
APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. |
|
| DC65817 |
Compound 4 (VHL-CDO1 glue degrader)
Featured
|
Compound 4 (VHL-CDO1 glue degrader) is a molecular glue degrader for cysteine dioxygenase 1 (CDO1) by recruiting it into the Von Hippel-Lindau (VHL) E3 ligase complex and leading to its selective degradation. |
|
| DC65818 |
CMX990
Featured
|
CMX990 is a novel covalent SARS-CoV-2 3CL protease inhibitor with EC50 of 10 nM, and shows good oral bioavailability and tolerability in preclinical species. Compared with nirmatrelvir, CMX990 has distinctly differentiated potency (~5-fold more potent in primary cells) and human in vitro clearance (>4-fold better microsomal clearance and >10-fold better hepatocyte clearance), with good in vitro-to-in vivo correlation. |
|
| DC65819 |
Acetylcholine
Featured
|
Acetylcholine is stored in vesicles in the presynaptic neuron. These fuse with presynaptic membrane upon stimulation by a nerve signal, thus, generating a pulse of neurotransmitter, which diffuses across the membrane. Acetylcholine may either bind reversibly to one of two different types of acetylcholine receptors on the postsynaptic membrane or be destroyed by the acetylcholine-hydrolyzing enzyme, acetylcholinesterase. |
|
| DC65820 |
Synucleozid-2.0
Featured
|
Synucleozid-2.0 is a drug-like small molecule that decreases α-Synuclein (SNCA) levels by inhibiting ribosomes from assembling onto SNCA mRNA. Synucleozid-2.0 dose-dependently inhibits SNCA translation with IC50 of ~2 µM. |
|
| DC65821 |
Upadacitinib hemihydrate
Featured
|
Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, being developed for the treatment of several autoimmune disorders. |
|
| DC65822 |
Valemetostat tosylate
Featured
|
Valemetostat (DS-3201) tosylate, a first-in-class EZH1/2 dual inhibitor with IC50 values ＜10 nM. Valemetostat tosylate can be used for the research of relapsed/refractory peripheral T-cell lymphoma. |
|
| DC65823 |
IR-820(New Indocyanine Green)
Featured
|
IR-820 is a near infrared dye with its excellent fluorescence penetration, good color rendering and better stability. IR-820 is an infrared blood pool contrast agent to detect and quantify diseased tissue in live animals. IR-820 has maximal excitation and emission wavelengths of 710 and 820 nm, respectively. IR-820 emission is significantly improved in vivo on serum binding to albumin, and elimination occurs predominantly via the gastrointestinal tract. Note: this product has ~80% dye. |
|
| DC65824 |
PKH 26
Featured
|
PKH 26 is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm), which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies. |
|
| DC65825 |
5(6)-Carboxyfluorescein
Featured
|
5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo. |
|
| DC65826 |
SYBR(R) GREEN I NUCLEIC ACID GEL STAIN
Featured
|
|
|
| DC65827 |
DiR
Featured
|
DiR is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins. |
|
| DC65828 |
Methylliberine
Featured
|
|
|
| DC65829 |
Tetramethyluric acid
Featured
|
Tetramethyluric acid (1,3,7,9-Tetramethyluric acid; Theacrine), also known as tetramethyluric acid or theophylline, is a purine alkaloid with a structure similar to caffeine. Tetramethyluric acid is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences. |
|
| DC65830 |
1-M-PES(1-Methoxy-5-methylphenazinium ethyl sulfate)
Featured
|
1-m-PES is an electron mediator which has higher stability of solutions than 1-Methoxy PMS. The stability in neutral to alkali conditions has been extremely improved with 1-Methoxy PES. 1-M-PES is a stable small-molecular compound and it has an equal or higher thermal stability than diaphorase. The 1-Methoxy PES solution can be stored long term. |
|
| DC60546 |
514O6,10
Featured
|
514O6,10 is an ionizable lipidoid. 514O6,10 formulated LNPs facilitate mRNA delivery to the pancreas. |
|
| DC60548 |
IBG1
Featured
|
IBG1 is a PROTAC-like degrader, which comprises JQ1 tethered to E7820. IBG1 selectively degraded BRD2 and BRD4 but not BRD3. IBG1 results in potent BRD4 degradation with DC50 of 0.15 nM and pronounces growth inhibition in various cancer cell lines. |
|
| DC60549 |
IBG3
Featured
|
IBG3 is a PROTAC-like degrader. IBG3 shows greater degradation efficiencies over BRD4 and BRD2 than those of IBG1 with DC50 of 6.7 pM and 8.6 pM, respectively. |
|
| DC60550 |
IBG4
Featured
|
IBG4 is a PROTAC-like degrader. IBG4 shows high specificity for BRD4 and does not efficiently degrade BRD2. |
|
| DC65831 |
LNK01001
Featured
|
|
|
| DC65832 |
GT20029
Featured
|
|
|
| DC65833 |
LNK01002
Featured
|
|
|
| DC65834 |
LNK01003
Featured
|
|
|
| DC65835 |
PF-04745637
Featured
|
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1. |
|
| DC65836 |
H5K29116
Featured
|
|
|
| DC65837 |
MZ-001
Featured
|
|
|
