| DC8878 |
SB 242084 |
SB 242084 is a potent and selective antagonist of 5-HT2C receptor. |
|
| DC7913 |
SB225002
Featured
|
SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. |
|
| DC4102 |
SB-269970,SB 269970
Featured
|
SB269970 is a potent and selective 5-HT7 receptor antagonist. |
|
| DC9316 |
SB 271046 (Hydrochloride) |
SB271046 Hcl is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
|
|
| DC7495 |
SB-334867 HCl
Featured
|
SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. |
|
| DC8419 |
SB-334867
Featured
|
SB-334867 is a selective orexin-1 (OX1) receptor antagonist. |
|
| DC8483 |
SB-399885 HCl
Featured
|
Potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT6 receptors respectively). |
|
| DC7277 |
SB-408124
Featured
|
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively; exhibits 50-fold selectivity over OX2 receptor. |
|
| DC9573 |
SB-674042
Featured
|
SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM); exhibits 100-fold selectivity for OX1 over OX2 receptors.
|
|
| DC8354 |
Intepirdine (SB-742457, RVT-101）
Featured
|
SB-742457(RVT-101) is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects. |
|
| DC10189 |
SCH 23390 hydrochloride
Featured
|
SCH 23390 hydrochloride is a potent dopamine receptor D1 antagonist with Ki values of 0.2 and 0.3 nM for the D1 and D5. |
|
| DC9409 |
SCH 546738 |
SCH 546738 is a novel, potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM .
|
|
| DC9410 |
SCH 527123 |
SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
|
|
| DC11912 |
Seliforant |
Seliforant (SENS-111, SENS111) is a novel potent, selective histamine H4 receptor antagonist.. |
|
| DC8624 |
Setipiprant(ACT129968)
Featured
|
Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2. |
|
| DC9320 |
Setiptiline (maleate) |
Setiptiline is a serotonin receptor antagonist.
|
|
| DC9319 |
Setiptiline |
Setiptiline(Org-8282) is a serotonin receptor antagonist.
|
|
| DCAPI1485 |
Silodosin
Featured
|
Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. Silodosin causes practically no orthostatic hypotension (in contrast to other α1 blockers). Since Silodosin is a highly selective inhibitor of the α1A adrenergic receptor, it ca |
|
| DC4108 |
Sitaxentan sodium
Featured
|
Sitaxentan sodium (TBC-11251) is a selective endothelin receptor-A antagonist with IC50 and Ki of 1.4 nM and 0.43 nM, respectively. |
|
| DC12379 |
SKF 38393
Featured
|
SKF 38393 is a partial agonist of the dopamine D1-like receptors D1 and D5 (Kis = 1 and ~0.5 nM, respectively). |
|
| DC9420 |
SKF-82958 (hydrobromide) |
SKF 82958 hydrobromide is a D1/D5 receptor full agonist. |
|
| DC8859 |
SKF38393 HCl
Featured
|
SKF38393 HCl is a selective dopamine D1/D5 receptor agonist. |
|
| DC7295 |
SphK-I2
Featured
|
SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. |
|
| DC9055 |
Sotalol HCl |
Sotalol Hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias. |
|
| DC4131 |
SR48692
Featured
|
SR 48692 is a neurotensin antagonist; selective for NTS1 over NTS2 (apparent affinity, Ke, is 36 nM for NTS1). Competitively inhibits binding of [125I]-neurotensin to HT29 and N1E115 cell membranes (IC50 values are 15.3 and 20.4 nM respectively). |
|
| DC9422 |
ST-836 (hydrochloride) |
ST-836 Hcl is a dopamine receptor ligand; Antiparkinsonian agent. |
|
| DCAPI1445 |
strontium ranelate |
Strontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Commonly used as an antiosteoporotic. |
|
| DC6906 |
Aprepitant (MK-0869, L-754030)
Featured
|
Substance P antagonists (SPA). |
|
| DC10664 |
Substance P free acid
Featured
|
Substance P free acid is a Sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission. |
|
| DC10663 |
Substance P
Featured
|
Substance P is a Sensory neuropeptide and inflammatory mediator. Exerts excitatory effects on central and peripheral neurons, constricts bronchioles and is involved in pain transmission. |
|
