| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DCR-004 | Ellagic acid | >98%,Standard References |
|
| DC5190 | 3-Deazaneplanocin A (DZNep） Featured | 3-deazaneplanocin A (DZNeP), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM. |
|
| DC11696 | CM-579 | A novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively. |
|
| DC11917 | (R)-OR-S1 | A novel SAM-competitive, highly selective, orally bioavailable EZH1/2 dual inhibitor with IC50 of 16/50 nM, respectively. |
|
| DC11820 | A-893 | A potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM. |
|
| DC11724 | MS-453 | A potent, selective. covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM. |
|
| DC10509 | A-196 Featured | A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. |
|
| DC7855 | A-366 Featured | A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM). |
|
| DC10129 | A395 Featured | A-395 potently inhibited the formation of H3K27me3 (via antagonizing EED in the trimeric PRC2 complex (EZH2:EED:SUZ12)) with IC50 = 34 ± 2 nM (Hill Slope = 0.7) |
|
| DC8292 | AMI-1 Featured | AMI-1 is a PRMT and HIV-1 RT polymerase inhibitor. |
|
| DC8537 | AZ505 Featured | AZ505 is a potent and highly selective inhibitor of the oncogenic protein SMYD2(IC50=0.12 uM) with potential anticancer activity, >600 fold than SMYD3(IC50>83.3 uM); DOT1L(IC50>83.3 uM);EZH2(IC50>83.3 uM). |
|
| DC10885 | BCI-121 Featured | BCI-121 is a SMYD3 inhibitor that impairs the proliferation of cancer cell. |
|
| DC7374 | BIX01294 Featured | BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM. |
|
| DC7674 | BRD4770 Featured | BRD4770 is a selective inhibitor of the histone methyltransferase G9a. |
|
| DC10795 | CM-272 Featured | CM-272 is a first-in-class reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies. |
|
| DC11477 | EBI-2511 Featured | EBI-2511 is a highly potent and orally active EZH2 inhibitor for the treatment of Non-Hodgkin’s Lymphoma. |
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|
| DC7927 | EPZ011989 Featured | EPZ011989 is a potent, orally-available EZH2 Inhibitor. |
|
| DC8012 | EPZ015666 Featured | EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs. |
|
| DC9267 | EPZ015866 Featured | EPZ015866(GSK591) is a potent, selective PRMT5 inhibitor. |
|
| DC9822 | EPZ020411 HCl Featured | EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ＞10 fold selectivity for PRMT6 over PRMT1 and PRMT8. |
|
| DC10887 | EPZ031686 Featured | EPZ031686 is a noncompetitive inhibitor for SMYD3 and MEKK2 with a Ki=1.2 and 1.1 nM respectively. |
|
| DC4242 | Pinometostat(EPZ5676) Featured | EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. |
|
| DC10679 | EZM2302 Featured | EZM2302 (GSK3359088) is the first potent and selective inhibitor of CARM1 enzymatic activity that exhibits anti-proliferative effects both in vitro and in vivo,in biochemical assays (IC50=6nM) with broad selectivity against histone methyltransferases. |
|
| DC11235 | Furamidine dihydrochloride Featured | Furamidine dihydrochloride (NSC 305831) tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM. |
|
| DC11071 | Gambogenic acid | Gambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge, shows potent antitumor activity and can effectively inhibit the survival and proliferation of cancer cells. |
|
| DC11070 | GNA002 | GNA002 (GNA-002) is a gambogenic acid (GNA) derivative that specifically and covalently binds to Cys668 within the EZH2-SET domain, trigges EZH2 degradation (IC50=1.1 uM) through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination. |
|
| DC10886 | GSK2807 Featured | GSK-2807 (GSK 2807, GSK2807) is a potent and selective, SAM-competitive inhibitor of SMYD3 with Ki of 14 nM. |
|
| DC10647 | EPZ015938(pemrametostat) Featured | GSK3326595(EPZ015938) is the first-in-class protein arginine methyltransferase-5 (PRMT5) inhibitor. |
|
| DC7143 | GSK-343 Featured | GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. |
|
| DC8044 | GSK503 Featured | GSK503 is a specific EZH2 methyltransferase inhibitor. |
|
