| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23884 | BPN-15606 | BPN-15606 (BPN15606) is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 by SHSY5Y neuroblastoma cells with IC50 of 7 nM. |
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| DC10387 | BPO-27 racemat | BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. |
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| DC8294 | BPR1J-097 Featured | BPR1J-097 is a novel small molecule FLT-3 inhibitor(IC50=11±7 nM) with promising in vivo anti-tumour activities; inhibits FLT-3 D835Y with an IC50 of 3 nM. |
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| DC21870 | BPR1J373 | BPR1J373 is a potent, orally available multitargeted kinase inhibitor, potently inhibits FLT3, c-KIT, VEGFR1-3, Aurora A, PDGFRα, PDGFRβ, RET, and SRC with IC50 values of <100 nM. |
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| DC20825 | BPR1K653 | BPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively. |
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| DC7951 | Glutaminase Inhibitor II, BPTES Featured | BPTES is a selective inhibitor of Glutaminase GLS1 (KGA) |
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| DC10618 | BPTU Featured | BPTU is an Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). |
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| DC8392 | BQ-123 Featured | BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. |
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| DC7542 | BQ-788 Featured | BQ-788 sodium salt is a potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells); poorly inhibited the binding to ET A receptors in human neuroblastoma cell line SK-N-MC cells (IC(50), 1300 nM). |
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| DC10515 | BQCA Featured | BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5. |
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| DC23763 | BQU-082 | BQU-082 is a novel potent small GTPase Ral (Ras-like) inhibitor with IC50 of 1.7 uM, displays a dose dependent effect on RalA and RalB activity in H2122 spheroids using the common RalBP1 pull-down assay.. |
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| DC8202 | BQU57 Featured | BQU57 is a potent and selective GTPase Ral Inhibitor. |
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| DC12641 | BR101549 | BR101549 (BR-101549) is a novel PPARγ non-TZD agonist with EC50 of 1.73 uM (Amax 120%).. |
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| DC23555 | BR103 | BR103 is a potent, metabolically stable and highly selective small molecule agonist of complement C3a receptor (C3aR) with EC50 of 22 ± 8 nM. |
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| DC23547 | BR111 | BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85 ± 40 nM (inhibition of hC3a induced Ca2+ release on human macrophages). |
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| DC20092 | BR351 | BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively. Potential tools for the molecular imaging of activated MMPs with PET. |
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| DC20096 | BR351 precursor | BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively. Potential tools for the molecular imaging of activated MMPs with PET. |
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| DC20827 | BRACO-19 | BRACO-19 is a potent small molecule Telomerase inhibitor (IC50=115 nM) that inhibits expression of human telomerase reverse transcriptase (hTERT). |
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| DC7809 | BRACO19 trihydrochloride Featured | BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest. |
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| DC20323 | Bractoppin Featured | Bractoppin is a potent, small-molecule chemical inhibitor that specific selectively blocks phosphopeptide recognition by the BRCA1 tBRCT domain with binding IC50 of 74 nM; shows no inhibition for recognition of cognate biotinylated phosphopeptides to the TOPBP1 tBRCT 7/8, or GRB2 SH2 proteins; engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket; inhibits substrate recognition detected by Förster resonance energy transfer, and diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51; selectively interrupts BRCA1 tBRCT-dependent signals evoked by DNA damage. |
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| DC7775 | Bradanicline (TC-5619) Featured | Bradanicline (TC-5619) is an experimental pharmaceutical drugthat acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. |
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| DC10338 | Bradykinin | Bradykinin is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions. |
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| DC7718 | B-Raf IN 1 Featured | B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM). |
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| DC8921 | B-Raf inhibitor 1 Featured | B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively. |
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| DC7008 | BRAF inhibitor Featured | BRAF inhibitor is a potent BRAF inhibitor. |
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| DC23752 | Bragsin1(Bragsin 1) | Bragsin1 (Bragsin 1) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM). |
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| DC12375 | Bragsin2 Featured | Bragsin2 is a novel PH-domain-binding inhibitor,inhibiting BRAG2-mediated Arf GTPase activation. |
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| DC7097 | Cebranopadol(GRT-6005) Featured | branopadol(GRT-6005) is a novel first in class compounds with potent agonist activity on ORL-1 (opioid receptor like -1) and the well established mu opioid receptor. |
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| DC9839 | Brassinin Featured | Brassinin is a Inducer of phase II enzymes. Moderate and competitive indoleamine 2,3-dioxygenase inhibitor (Ki = 98 μM). Shows chemopreventive effects in vivo. Orally active. |
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| DC23100 | Brassinolide Featured | Brassinolide is a predominant plant growth modulator that regulate plant cell elongation. It is active against herpes and arena viruses. |
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