| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DCAPI1119 | Cathepsin Inhibitor 1 Featured | Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
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| DC8482 | CAY10415(MSDC-0160) Featured | CAY10415 is a potent, antidiabetic drug of the TZD structural class. |
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| DC10847 | CAY10441（RO1138452） Featured | CAY10441 is a Selective prostacyclin IP receptor antagonist. |
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| DC10903 | CAY10465 Featured | CAY10465 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor agonist, with a Ki of 0.2 nM. |
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| DC10516 | LW6(CAY10585) Featured | CAY10585 prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM, respectively. |
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| DC12099 | CAY10595 | CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM. |
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| DC10579 | CAY 10602 Featured | CAY10602 is a SIRT1 activator. |
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| DC8036 | CAY10603 Featured | CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. |
|
| DC7738 | CAY10683(Santacruzamate A) Featured | CAY10683 is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. |
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| DC20607 | Cazpaullone | Cazpaullone (9-Cyano-1-azapaullone) is a derivative of 1-Azakenpaullone, a potent, selective GSK3β inhibitor with IC50 of 8 nM, weakly inhibits CDK1/cyclin B and CDK5/p25 (IC50=0.5 and 0.3 uM). |
|
| DC4160 | CB-03-01 Featured | CB-03-01 is a steroidal ester, androgen antagonist derived from 11-deoxycortisone, which tightly mimics the profile of an ideal anti-androgen for topical use. |
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| DC11709 | CB-1158 | CB-1158 (INCB-01158) is a potent, selective, oral available Arginase inhibitor with IC50 of 98 nM. |
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| DC8840 | CB-5083 Featured | CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . |
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| DC22986 | CB5305630 | CB5305630 is a potent and noncompetitive IRE1 RNase inhibitor with IC50 of 60 nM in the FRET-derepression assay. |
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| DC20861 | CB-618 | CB-618 (CB 238618) is a novel non-β-lactam β-lactamase inhibitor that potentiates meropenem MIC values against clinical Enterobacteriaceae isolates. |
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| DC20862 | CB-618 sodium salt | CB-618 (CB 238618) is a novel non-β-lactam β-lactamase inhibitor that potentiates meropenem MIC values against clinical Enterobacteriaceae isolates. |
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| DC20052 | CB-6644 Featured | CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM. |
|
| DC20863 | CB-6673567 | CB-6673567 is a potent, selective Adenylyl Cyclase 1 (AC1) inhibitor with IC50 of 77 uM, displays a 2- to 4-fold isoform selectivity over AC6. |
|
| DC10449 | CB7921220 Featured | CB7921220 is an inhibitor of Adenylyl Cyclase isoform-1 (AC1) and isoform-6 (AC6). |
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| DC8042 | CB-839(Telaglenastat) Featured | CB-839 is a potent, selective, reversible and orally bioavailable inhibitor of human glutaminase. |
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| DC10944 | CBB3001 | CBB3001 (CBB-3001) is a novel potent, selective histone demethylase LSD1 inhibitor with IC50 of 21.25 uM. |
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| DC12623 | CBK289001 | CBK289001 (CBK-289001) is a small molecule inhibitor of Tartrate-resistant acid phosphatase (TRAP/ACP5), demonstrates efficacy in a migration assay and IC50 values from 4 to 125 uM.. |
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| DC10617 | CBL0137 Featured | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. |
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| DC8377 | CC-115 Featured | CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. |
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| DC10146 | CC-122（Avadomide） Featured | CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity.CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL. |
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| DC8497 | CC-223 Featured | CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM). |
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| DC7096 | CC-401 Featured | CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. |
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| DC20866 | CC-671 Featured | CC-671 is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively. |
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| DC12532 | CC-90003 | CC-90003 (CC90003) is a potent and selective, covalent ERK1/2 inhibitor with IC50 of 10-20 nM, demonstrates excellent selectivity in a 258-kinase biochemical assay panel. |
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| DC12590 | CCB 02 Featured | CCB02 (CCB 02) is a specific small molecule inhibitor of CPAP-tubulin interaction with IC50 of 0.689 uM in AlphaScreen assay, selectively binds at the CPAP binding site of tubulin. |
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