| DC9095 |
Carboplatin
Featured
|
Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cell's repair mechanism. |
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| DC8705 |
Carbosulfan |
Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4. |
|
| DC12087 |
Carboxy pyridostatin trifluoroacetate salt |
Carboxy pyridostatin trifluoroacetate salt has the peculiarity to exhibit high molecular specificity for RNA over DNA G4s. |
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| DC9384 |
Carboxypeptidase G2 (CPG2) Inhibitor
Featured
|
Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents. |
|
| DC6502 |
cardamonin
Featured
|
Cardamonin, isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity. |
|
| DC8456 |
Cardiogenol C (hydrochloride)
Featured
|
Cardiogenol C is a diaminopyrimidine that induces cardiomyogenesis in mouse embryonic stem cells. |
|
| DC24127 |
Cardiogenol C hydrochloride |
Cardiogenol C is a small cell-permeable molecule that selectively and efficiently induce mouse embryonic stem cells (ESCs) to differentiate into cardiomyocytes with EC50 of 0.1 uM. |
|
| DC23875 |
Cardionogen 1 |
Cardionogen 1 (CDNG1) is a small molecule that promotes cardiomyocyte generation by modulating Wnt signaling. |
|
| DC23881 |
Cardionogen 2 |
Cardionogen 2 (CDNG2) is a small molecule that promotes cardiomyocyte generation by modulating Wnt signaling. |
|
| DC1002 |
Carfilzomib (PR-171)
Featured
|
Carfilzomib is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells,showed potent activity against COVID-19(SARS-COV-2). |
|
| DC7990 |
Cariporide |
Cariporide is a selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). |
|
| DC8054 |
Cariprazine (RGH-188)
Featured
|
Cariprazine (RGH-188) is a novel putative antipsychotic drug that exerts partial agonism at dopamine D2/D3 receptors, with preferential binding to D3 receptors, and partial agonism at serotonin 5-HT1A receptors. |
|
| DC9012 |
Carisoprodol |
Carisoprodol is a centrally acting skeletal muscle relaxant of the carbamate class and produces all the effects associated with barbiturate receptor ligands. |
|
| DC21875 |
CARM1 inhibitor 9 |
CARM1 inhibitor 9 is a potent, selective inhibitor of arginine methyltransferase 1 (CARM1, PRMT4) with IC50 of 94 nM. |
|
| DC24110 |
CARM1-IN-1
Featured
|
CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7). |
|
| DC8972 |
Carmustine
Featured
|
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent. |
|
| DC20119 |
Carnostatine (SAN9812) |
Carnostatine (SAN9812) is a specific and highly selective carnosinase (CN1) inhibitor with a Ki of 11 nM. |
|
| DC11354 |
Carteolol (hydrochloride) |
Carteolol is an antagonist of β-adrenergic receptors (Kd = 13 nM). |
|
| DC8113 |
Carubicin
Featured
|
Carubicin is an anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. |
|
| DC9119 |
Carvedilol |
Carvedilol(BM14190) is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation. |
|
| DC10539 |
POL1 inhibitor(POL1-IN-1)
Featured
|
CAS 1822358-25-7 |
|
| DC11250 |
Casein Kinase inhibitor A51
Featured
|
Casein Kinase inhibitor A51 (CKIα inhibitor A51) is a novel pan-specific CKI (CSNK1) inhibitor (Kd=0.5-20 nM, CKIα Kd=5.3 nM) that co-targets the transcriptional kinases CDK7 and CDK9, with hardly inhibition of CDK8, CDK13, CDK11a, CDK11b, and CDK19; target both CDK7 and CDK9 with low nM Kd values; induces leukemia cell apoptosis at <160 nM, in correlation to the capacity to stabilize p53; shows high and selective sensitivity against leukemic CFUs in colony-forming unit (CFU) assay, without effect on normal hematopoietic CFUs; blocking CKIα together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, induce apoptosis, abolishes the expression of MYC, MDM2, and the anti-apoptotic oncogene MCL1; demonstrates therapeutic efficacy with preserved hematopoiesis and leukemia cure potential in AML mouse models. |
|
| DC11251 |
Casein Kinase inhibitor A86 |
Casein Kinase inhibitor A86 (CKIα inhibitor A86) is a novel pan-specific CKI (CSNK1) inhibitor (Kd=1-10 nM, CKIα Kd=9.8 nM) that co-targets the transcriptional kinases CDK7 and CDK9, with hardly inhibition of CDK8, CDK13, CDK11a, CDK11b, and CDK19. |
|
| DC8013 |
CASIN
Featured
|
CASIN is a Cdc42 GTPase inhibitor (IC50 = 2 μM). |
|
| DC22402 |
Casopitant |
Casopitant (GW679769) is a potent, centrally-acting neurokinin 1 (NK1) receptor antagonist (pKi=9.48) with antidepressant and antiemetic activities. |
|
| DC22403 |
Casopitant mesylate
Featured
|
Casopitant (GW679769) is a potent, centrally-acting neurokinin 1 (NK1) receptor antagonist (pKi=9.48) with antidepressant and antiemetic activities. |
|
| DCAPI1497 |
Cancidas
Featured
|
Caspofungin is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acts by inhibition of the synthesis of β (1,3)-D-glucan, an e |
|
| DC22047 |
CAT639 |
CAT639 is an improved analog of ATV399 that exhibits improved β-cell viability and insulin secretion in the rat insulin-producing INS1E cells and primary rat dispersed islet cells, inhibits dimerization of iNOS. |
|
| DCAPI1130 |
Catharanthine |
Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 µM. |
|
| DC22206 |
Cathepsin B inhibitor RC1 |
Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes. |
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