| DC73865 |
W6134 |
W6134 (RORγ covalent inhibitor 29) is a first-in-class, potent and selective RORγ covalent inhibitor with IC50 of 0.21 uM, targets the Cys320 of RORγ. |
|
| DC73866 |
CS27109
Featured
|
CS27109 is a potent, selective thyroid hormone receptor-β (THR-β) agonist with AC50 value of 1.98 uM, 12.6-fold selectivity over THR-α. |
|
| DC73867 |
EN171
Featured
|
EN171 covalently targets both C38 and C96 on 14−3−3 to enhance 14−3−3 interactions with ERα, YAP, and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. |
|
| DC73868 |
CNB-001 |
CNB-001 is a pyrazole derivative of curcumin with neuroprotective properties, inhibits extracellular Aβ toxicity in hippocampal neurons with EC50 of 400 nM. |
|
| DC73869 |
DDQ |
DDQ is a small molecule inhibitor of binding sites of Amyloid beta (Aβ) and Drp1, reduces interaction between Aβ and Drp1, shows anti-aging effects. |
|
| DC73870 |
MeSC-04 |
MeSC-04 is a potent α-Syn amyloid formation inhibitor, reduces the number and size of amyloid fibrils in vitro. |
|
| DC73871 |
NPT200-11 |
NPT200-11 is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor. |
|
| DC73872 |
SRI-42667 |
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability. |
|
| DC73873 |
CC-8977 |
CC-8977 is a hgihly potent, selective inhibitor of calcium/calmodulin-dependent kinase kinase II (CaMKK2) with binding IC50 of 7 nM. |
|
| DC73874 |
SMP-114 |
SMP-114 (Rimacalib) is a potent, specific and orally available CaMKII inhibitor with potential for treatment of rheumatoid arthritis. |
|
| DC73875 |
BMS-332 |
BMS-332 (BMS332) is a potent, selective dual DGKα/ζ inhibitor with IC50 of 9/8 nM respectively. |
|
| DC73876 |
BMS-684 |
BMS-684 (BMS684) is a potent, selective inhibitor of diacylglycerol kinase α(DGKα) with IC50 of 15 nM, weakly inhibist DGKβ and DGKγ, does not inhibit other DGK lipid kinases. |
|
| DC73877 |
JNJ-3790339 |
JNJ-3790339 is a potent and selective inhibitor of diacylglycerol kinase α (DGKα), demonstrates similar cytotoxicity in GBM and melanoma cells as ritanserin. |
|
| DC73878 |
GRL018-21 |
GRL018-21 is a highly selective, potent, and non-covalent GRK5 inhibitor with IC50 of 10 nM, >100,000-fold selectivity over GRK2. |
|
| DC73879 |
(3S) ALG-05 |
(3S) ALG-05 is a potent pan-inhibitor of gut microbia tryptophan-indole-lyases (TILs, E.C. 4.1.99.1), exhibits inhibitory activity across TILs with Ki of 7-11 uM. |
|
| DC73880 |
(R)-HTS-3 |
(R)-HTS-3 is a small-molecule inhibitor of LPCAT3, an integral membrane acyltransferase in the Lands cycle responsible for generating C20:4 phospholipids. |
|
| DC73881 |
(R)-SKBG-1
Featured
|
(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation. |
|
| DC73882 |
(S)-CKi-1
Featured
|
(S)-CKi-1 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 0.6 uM, depletes creatine phosphagen energetics in cells. |
|
| DC73883 |
(S)-IBD3540 |
(S)-IBD3540 is a potent, gut-restricted and orally active small molecule glutamate carboxypeptidase II (GCPII) inhibitor with IC50 of 4 nM, demonstrates anti-colitis activity in both acute and chronic mouse colitis models. |
|
| DC73884 |
2,5-pyridinedicarboxylic acid |
2,5-pyridinedicarboxylic acid is a highly selective D-dopachrome tautomerase (D-DT, MIF2) inhibitor with Ki of 17.2 uM, 79-fold selectivity over MIF, effectively blocks the D-DT-induced activation of CD74. |
|
| DC73885 |
2-TCPA |
2-TCPA is a potent, specific inhibitor of carbamoyl-phosphate synthetase, aspartate transcarbamoylase, and dihydroorotase (CAD), suppresses SARS-CoV-2 replication in Caco-2 cells with IC50 of 2.36 uM. |
|
| DC73886 |
3-mercaptopicolinic acid hydrochloride |
SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK, PCK) inhibitor with Ki of 2-9 uM, an inhibitor of gluconeogenesis. |
|
| DC73887 |
4BPPNit |
4BPPNit is a small molecule significantly augmented glycosylation of α-dystroglycan, in part through upregulation of LARGE1 glycosyltransferase gene expression. |
|
| DC73888 |
4-Sulfocalix[6]arene hydrate |
4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
|
| DC73889 |
4-Sulfocalix[8]arene hydrate |
4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
|
| DC73890 |
5M-8OH-Q
Featured
|
5M-8OH-Q is a specific small molecule inhibitor of UDP-glucose glycoprotein glucosyltransferase (UGGT), binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs (Kd=47 uM) but not present in other GT24 family glycosyltransferases. |
|
| DC73891 |
7-Fluorotryptamine |
7-fluorotryptamine (7FTA) is a potent synthetic agonist of GPRC5A with EC50 of 7.2 uM for inducing GPRC5A-mediated β-arrestin recruitment. |
|
| DC73892 |
7-Fluorotryptamine hydrochloride |
7-fluorotryptamine (7FTA) is a potent synthetic agonist of GPRC5A with EC50 of 7.2 uM for inducing GPRC5A-mediated β-arrestin recruitment. |
|
| DC73893 |
AD-5584 |
AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells. |
|
| DC73894 |
AD-8007 |
AD-8007 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells. |
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