| DC7447 |
KU14R |
KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines. |
|
| DC21208 |
KuWal151 |
KuWal151 is a potent, selective cdc2-like kinase (CLK) inhibitor with IC50 of 88/510/28 nM for CLK1/2/4, respectively. |
|
| DC7449 |
KW-2478
Featured
|
KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1/2 |
|
| DC21211 |
KX2-361 |
KX2-361 (KX 02) is a potent, dual Src signaling/tubulin polymerization inhibitor that are under clinical evaluation.. |
|
| DC21212 |
KY-02061 |
KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay. |
|
| DC21213 |
KY-02327 |
KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog. |
|
| DC21214 |
KY-04045 |
KY-04045 is a novel PAK4 inhibitor with IC50 of 8.7 uM, a basic building block in designing novel imidazo[4,5-b]pyridine-based PAK4 inhibitors.. |
|
| DC22132 |
KY-05009
Featured
|
KY-05009 (KY05009) is a potent, ATP-competitive inhibitor of Traf2- and Nck-interacting kinase (TNIK) with Ki of 100 nM. |
|
| DC9889 |
Kynurenic acid |
Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist. |
|
| DC12332 |
KZR-504 |
KZR-504 is a highly selective and orally active inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. |
|
| DC21217 |
L 873724 |
L 873724 is a potent and selective non-basic cathepsin K inhibitor with IC50 of 0.2 nM, shows no significant potency against Cat B, L, and S (IC50= 5239, 264, and 178 nM). |
|
| DC2076 |
L-165041
Featured
|
L-165041 is a potent PPARδ agonist (Ki = 6 nM). |
|
| DC22070 |
L-257 |
L-257 (DDAH-1 inhibitor L-257) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM. |
|
| DC22071 |
L-291 |
L-291 (DDAH-1 inhibitor L-291) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM. |
|
| DC21215 |
L-338192 |
L-338192 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 29 uM in AlphaScreen assay. |
|
| DC23595 |
L-364373 |
L-364373 (R-L3) is a stereospecific activator of cardiac slowly activating delayed rectifier K+ current (IKs) and KV7.1 (KCNQ1) channels. |
|
| DC20041 |
L-5-Hydroxytryptophan (L-5-HTP; Oxitriptan)
Featured
|
L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist. L-5-Hydr |
|
| DC11377 |
L-826,266 |
L-826,266 is a potent and selective competitive antagonist of the prostaglandin E2 receptor subtype EP3 (Ki = 0.8 nM). |
|
| DC9382 |
Lacidipine |
Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. |
|
| DC20850 |
Lactimidomycin |
Lactimidomycin is a glutarimide antibiotic that has antifungal, antiviral and anti-cancer properties, acting as a direct inhibitor of protein translation in ribosomes. |
|
| DC21218 |
LAF389 |
LAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800 nM for MetAP-2, inhibits both MetAp1 and 2, potently inhibits HUVEC proliferation with IC50 of 20 nM. |
|
| DC1108 |
Laninamivir (CS-8958)
Featured
|
Laninamivir (CS-8958) is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B. |
|
| DC23824 |
Lanperisone |
Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion. |
|
| DC23502 |
L-AP4
Featured
|
L-AP4 is a selective group III metabotropic glutamate receptor agonist.. |
|
| DC9433 |
Lapatinib (ditosylate) |
Lapatinib ditosylate(GW-572016 ditosylate) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
|
|
| DC12472 |
LAS195319 |
LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα. |
|
| DC12443 |
LASV inhibitor 3.3
Featured
|
LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM), inhibits LASV GP-mediated infection and cross-links to the LASV receptor, LAMP1, in cells; does not inhibits the GP-mediated infection of LCMV, LuJo |
|
| DC12188 |
Lathosterol
Featured
|
Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis. |
|
| DC9877 |
Lauric Acid |
Lauric Acid is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil. |
|
| DC9512 |
Lazabemide
Featured
|
Lazabemide(Ro 19-6327/000) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively).
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