| DC22136 |
LEI 110
Featured
|
LEI110 (LEI－110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6). |
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| DC12562 |
LEM-14
Featured
|
LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3.. |
|
| DC12563 |
LEM-14-1189 |
LEM-14-1189 is a LEM-14 derivative that differentially inhibits the NSDs with in vitro IC50 of 418 μM (NSD1), IC50 of 111 μM (NSD2) and IC50 of 60 μM (NSD3).. |
|
| DC23882 |
LEQ 506 |
LEQ 506 (NPV-LEQ 506) is a second-generation inhibitor of Smoothened (Smo) with IC50 of 2 nM and 4 nM for human and mouse Smo, respectively. |
|
| DC8905 |
Lercanidipine
Featured
|
Lercanidipine is a calcium channel blocker of the dihydropyridine class. |
|
| DC5052 |
Lersivirine（UK 453061）
Featured
|
Lersivirine (UK-453061) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for the treatment of HIV-1 infection. |
|
| DC23569 |
Lesogaberan |
Lesogaberan (AZD-3355) is a potent, selective, peripherally acting GABAB receptor agonist with Ki of 5 nM and EC50 of 8.6 nM, 274-fold selectivity over GABAA (Ki=1.4 uM). |
|
| DC22807 |
Lestaurtinib
Featured
|
Lestaurtinib (KT-5555, CEP-701) is a potent, orally active JAK2, FLT3 and TrkA inhibitor with IC50 of 0.9 nM, 3 nM and < 25 nM, respectively. |
|
| DC21731 |
Letaxaban |
Letaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8 nM for hFXa, >440-fold selectivity than thrombin and negligible effects on trypsin, plasmin, and tPA. |
|
| DC12543 |
Lethal toxin inhibitor DN1 |
Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) wit |
|
| DC20434 |
Leucettamine B |
Leucettamine B is a potent inhibitor of CLK1 (IC50=15 nM), Dyrk1A (IC50=40 nM), and Dyrk2 (IC50=35 nM) and a moderate inhibitor of CLK3 (IC50=4.5 uM).. |
|
| DC8688 |
Leupeptin hemisulfate
Featured
|
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor, which has been shown to inhibit cathepsins B, H, L, and S, calpain, and trypsin. Leupeptin hemisulfate is an orally active, antioxidant and anti-inflammatory agent. |
|
| DC22504 |
Leuprorelin
Featured
|
Leuprorelin (Leuprolide) is a GnRH analog and agonist of GnRH receptor, interrupts the normal pulsatile stimulation and desensitizing of the GnRH receptors.. |
|
| DC8714 |
Levobetaxolol hydrochloride
Featured
|
Levobetaxolol hydrochloride is a beta-adrenergic receptor inhibitor (beta blocker), used to lower the pressure in the eye in treating conditions such as glaucoma. |
|
| DC8675 |
Levodropropizine |
Levodropropizine is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug. |
|
| DC10257 |
Levofloxacin hydrate |
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. |
|
| DC22727 |
LGB-321 |
LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively. |
|
| DC22137 |
LGD2226
Featured
|
LGD-2226 (LGD2226) is an orally active, selective androgen receptor modulator (SARM) with binding Ki of 1 nM, >1000-fold selectivity over GR,PR, MR and ER. |
|
| DC10278 |
LGD-6972
Featured
|
LGD-6972 is a selective and orally active glucagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research. |
|
| DC25068 |
L-g-glutamyl-p-nitroanilide hydrochloride |
L-g-glutamyl-p-nitroanilide hydrochloride is a potent, competitive inhibitor of the neutral amino acid transporter ASCT2 (SLC1A5) with pKa of 13.79. |
|
| DC9895 |
L-Glutamic acid monosodium salt |
L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. |
|
| DC12206 |
L-Hexanoylcarnitine
Featured
|
L-Hexanoylcarnitine is an acylcarnitine and is found to be associated with celiac disease. |
|
| DC12612 |
LHF-535 |
LHF-535 (LHF535, LHF 535) is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein, exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses with IC50 of 0.1-0.3 nM. |
|
| DC10312 |
L-Homocysteine thiolactone hydrochloride |
L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of homocysteine; prevents translational incorporation of homocysteine into proteins. |
|
| DC8751 |
Licofelone |
Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis. |
|
| DC10225 |
Lidocaine hydrochloride |
Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. |
|
| DC20198 |
Lifirafenib;BGB-283;Beigene-283 |
Lifirafenib (BGB-283) potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant. |
|
| DC10099 |
BGB283 |
Lifirafenib（BGB-283） is a Novel potent and selective RAF Kinase and EGFR inhibitor. |
|
| DC21914 |
LIMK1 and 2 dual inhibitor |
LIMK1 and 2 dual inhibitor is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM). |
|
| DC21915 |
LIN28 inhibitor LI71
Featured
|
LIN28 inhibitor LI71 is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 7 uM, binds the cold shock domain to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells. . |
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