Cat. No. | Product name | CAS No. |
DC21758 |
TNP-470
TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis. |
129298-91-5 |
DC10381 |
TOFA
TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA ). |
54857-86-2 |
DC20922 |
Tofimilast
Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively. |
185954-27-2 |
DC23156 |
Tofogliflozin
Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively. |
903565-83-3 |
DC7826 |
Tofogliflozin hydrate
Tofogliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2). |
1201913-82-7 |
DC11357 |
Tolazamide
Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 µM in HEK293 cells transfected with the human receptor). |
1156-19-0 |
DC8682 |
Tolclofos-methyl
Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide that is used as a see treatment for protection against soil-borne and seed borne fungal pathogens that caused seed decay and seedling blights. |
57018-04-9 |
DC8711 |
Tolmetin sodium dihydrate
Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory agent (NSAID) with antioxidant and neuroprotective properties. |
64490-92-2 |
DC8939 |
Tolrestat
Featured
Tolrestat(AY-27773) is a potent, orally active aldose reductase inhibitor with IC50 value of 35 nM. |
82964-04-3 |
DC8637 |
Toltrazuril sulfone
Toltrazuril sulfone is an antiprotozoal agent that acts upon Coccidia parasites. |
69004-04-2 |
DC20746 |
Tomeglovir
Tomeglovir (BAY 384766) is a potent, highly selective, nonnucleoside inhibitor of cytomegalovirus (CMV) replication. |
233254-24-5 |
DC9452 |
Tonabersat
Tonabersat (SB220453) is a gap-junction modulator. |
175013-84-0 |
DC22712 |
Toreforant
Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors. |
952494-46-1 |
DC7630 |
Tedizolid
Featured
Torezolid (TR-701; tedizolid) is a novel oxazolidinone for gram-positive infections. |
856866-72-3 |
DC8924 |
Torezolid phosphate
Torezolid phosphate is a novel oxazolidinone for gram-positive infections, has an IC50 of 8.7 μM and 5.7 μM for monoamine oxidase (MAO)-A and MAO-B, respectively. |
856867-55-5 |
DC9332 |
Tozadenant
Tozadenant (SYN-115) is an adenosine A2A receptor antagonist. |
870070-55-6 |
DC21759 |
TP003
TP003 is a potent, functional selectivity for α3 subunit-containing GABAA receptor agonist with Ki of <1 nM for α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2, has no affinity for α4β3γ2 and α6β3γ2 (Ki>1 uM). |
628690-75-5 |
DC22249 |
TP-004
TP-004 is a potent, selective METAP2 (Methionine aminopeptidase-2) inhibitor.. |
1454299-21-8 |
DC20200 |
TP0427736 HCl
TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with a |
864374-00-5 |
DC21760 |
TP-064
TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) for PRMT4 over other PRMTs. |
2080306-20-1 |
DC21761 |
TP-064N
TP-064N is a negative control chemical of TP-064, which is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM.. |
|
DC12561 |
TP238
TP-238 (TP238) is a CECR2/BPTF bromodomains chemical probe with IC50 of 30nM against CECR2 and 350nM against BPTF in an alphascreen assay, KD of 10nM for CECR2 and 120nM for BPTF in ITC assays. |
|
DC8365 |
TP-353
TP-353,TP353 |
|
DC10946 |
TP455
TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells. |
2042563-95-9 |
DC23390 |
TP-472
TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM. |
2079895-62-6 |
DC21291 |
TPA023
TPA023 is a potent, α2/α3 subtype-selective, and oral GABAA receptor agonist with Kd of 0.92, 1.05 and 0.58 nM for α1-, α2-, α3-, and α5-containing human receptors. |
252977-51-8 |
DC23656 |
TPA023B
TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype. |
425377-76-0 |
DC7159 |
TPCA-1
Featured
TPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.9 nM) that displays>22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. |
507475-17-4 |
DC11319 |
TPMPA
Featured
TPMPA is a GABAA-ρ1 (ρ1 GABAC) receptor antagonist that is 8-fold selective for GABAA-ρ1 over GABAA-ρ2 (ρ2 GABAC) receptors expressed in X. |
182485-36-5 |
DC23676 |
TPN729
TPN729 is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11. |
936951-20-1 |
DC23669 |
TPN729 maleate
TPN729 maleate is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11. |
1422955-53-0 |
DC10190 |
TPOP146
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. |
2018300-62-2 |
DC12628 |
TR-100
TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments. |
1128165-86-5 |
DC10611 |
Trabectedin
Featured
Trabectedin (Ecteinascidin-743 or ET-743) is a novel antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo. |
114899-77-3 |
DC21663 |
TRAF-STOP 6860766
TRAF-STOP 6860766 (SMI-6860766, SMI6860766) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity. |
433234-16-3 |
DC22818 |
TRAF-STOP 6877002
TRAF-STOP 6877002 is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity. |
433249-94-6 |
DC9598 |
TRAM-34
Featured
TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). |
289905-88-0 |
DC20570 |
trans Ned-19
trans Ned-19 is a cell-permeant chemical probe for the Ca(2+)-releasing second messenger NAADP, blocks NAADP signaling (IC50=6 nM, inhibition of Ca2+ release). |
1354235-96-3 |
DC20040 |
Trans-Anethole ((E)-Anethole)
Trans-Anethole ((E)-Anethole), a phenylpropene derivative isolated from Pimpinella, shows estrogenic activity at lower concentrations and cytotoxic at higher concentrations in cancer cell lines. Trans-Anethole ((E)-Anethole) contributes a large component |
4180-23-8 |
DC20143 |
trans-Cinnamic acid (trans-3-Phenylacrylic acid)
trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1. |
140-10-3 |
DC12170 |
Transcrocetinate disodium (Disodium trans-crocetinate)
Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. |
591230-99-8 |
DC8295 |
trans-Tranilast
Featured
trans-Tranilast (trans-MK-341) is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis. |
70806-55-2 |
DC20152 |
trans-Zeatinriboside
trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. |
6025-53-2 |
DC6914 |
Trelagliptin succinate
Featured
Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). |
1029877-94-8 |
DC7521 |
Trelagliptin
Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). |
865759-25-7 |
DC24188 |
Trenbolone acetate
Trenbolone acetate (RU-1697,17beta-TBOH) is a potent testosterone analog and selective androgen receptor modulator, is an androgen ester and a long-acting prodrug of trenbolone. |
10161-34-9 |
DC21120 |
Trequinsin hydrochloride
Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM. |
78416-81-6 |
DC8891 |
Tresitope
Tresitope is a thyroid hormone generated by deiodination of the prohormone thyroxine (T4); is a potent agonist of both thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both). |
6893-02-3 |
DC21567 |
Triazavirin (Riamilovir)
Featured
Triazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown efficacy against influenza A and B, including the H5N1 strain. It appears that Triazavirin has shown promise in reducing influenza disease severity and associated complications.5 Given the similarities between SARS-CoV-2 and H5N1, health officials are investigating Triazavirin as an option to combat SARS-CoV-2, the coronavirus responsible for COVID-19. |
928659-17-0 |
DC8757 |
Triciribine
Triciribine(API-2; NSC 154020) is a DNA synthesis inhibitor, also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively; does not inhibit PI3K/PDK1; 5000-fold less active in cells lacking adenosine kinase. |
35943-35-2 |
DC10251 |
Triclosan
Triclosan is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action. |
3380-34-5 |
DC20571 |
TRIF agonist AV-C
Featured
TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM). |
620589-62-0 |
DC23713 |
Trifarotene
Trifarotene (CD5789, CD-5789) is a potent and selective RARγ agonist with EC50 of 7.7 nM, 500- and 125-fold selectivity over RARα and RARβ. |
895542-09-3 |
DC8683 |
Trifluralin
Trifluralin is a commonly used pre-emergence herbicide. Trifluralin is generally applied to the soil to provide control of a variety of annual grass and broadleaf weed species. It inhibits root development by interrupting mitosis, and thus can control wee |
1582-09-8 |
DC9407 |
Triflusal
Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1. |
322-79-2 |
DC22019 |
Trigriluzole
Trigriluzole (BHV-4157) is a novel glutamate modulator for the treatment of mild-to-moderate Alzheimer’s disease (AD). |
1926203-09-9 |
DC23380 |
TRIM24 inhibitor X
Featured
TRIM24 inhibitor X is a potent TRIM24 bromodomain inhibitor for synthesis dTRIM24.. |
1884199-58-9 |
DC20126 |
Trimethoprim 3-oxide (Trimethoprim 3-N-oxide)
Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim. |
27653-67-4 |
DC21762 |
Triphenyl compound A
Triphenyl compound A (TPh A) is a small-molecule inhibitor of nuclear protein Pirin with Kd of 0.6 uM, inhibits the interaction between pirin and Bcl3 in vitro and in cells. |
21306-65-0 |
DC24126 |
Triptorelin
Featured
Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH), shows greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion.. |
57773-63-4 |
DC20065 |
PF-06733804
Featured
Trk-IN-3 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect. |
1873373-33-1 |
DC20066 |
Trk-IN-4
Trk-IN-4 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect. |
1799788-94-5 |
DC21763 |
TRO 40303
TRO 40303 is a novel cardioprotective compound that delays mitochondrial permeability transition pore (mPTP) opening, binds specifically to TSPO at the cholesterol site (Ki=150 nM). |
949080-24-4 |
DC9538 |
TRO 19622
Featured
TRO19622, a small cholesterol-like molecule, is a neuroregenerative and neuroprotective compound. |
22033-87-0 |
DC8903 |
Troglitazone
Troglitazone(CS-045), PPARγ agonist, is an anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity. |
97322-87-7 |
DC8679 |
Troxipide
Troxipide is a novel gastro protective agent with antiulcer, anti-inflammatory and mucus secreting properties. |
30751-05-4 |
DC21964 |
TRPM4 inhibitor 5
Featured
TRPM4 inhibitor 5 is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx). |
351424-20-9 |
DC10217 |
TRx0237 (LMTX) mesylate
Featured
TRx 0237 (LMTX™) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
1236208-20-0 |
DC11091 |
TRX-0237
TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity. |
613-11-6 |
DC11087 |
TRX-818 sodium
TRX-818 sodium (Foslinanib sodium ) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, induces cancer cell apoptosis and inhibits cancer cell proliferation. |
1256037-62-3 |
DC12464 |
TTGM 5826
TTGM 5826 (TTGM5826, TTGM-5826) is a small molecule, potential modulator of tissue transglutaminase (tTG) conformation. |
330471-93-7 |
DC23396 |
TTK21(CBP-p300 activator TTK21)
Featured
TTK21 (CBP-p300 activator TTK21) is a small molecule activator of CBP/p300 histone acetyltransferase activity with a maximal effect at a concentration of 275 uM. |
709676-56-2 |
DC22250 |
TTP399
TTP399 (TTP-399) is a hepatoselective, oral Glucokinase (GK) activator with EC50 of 304 nM and 762 nM for human GK at high glucose concentration (15 mM) and normoglycemia (5 mM), respectively. |
|
DC21764 |
TTP-8307
TTP-8307 is a potent inhibitor of the replication of several Rhinoviruses and Enteroviruses, targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 uM. |
950225-08-8 |
DC20075 |
Tubulin inhibitor 1
Tubulin inhibitor 1 is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis. |
2237054-53-2 |
DC12337 |
Tubuloside A
Tubuloside A is a phenylethanoid glycoside with antioxidative effect and hepatoprotective activity. |
112516-05-9 |
DC4167 |
Tulathromycin A
Tulathromycin is a new semi-synthetic member of the macrolide group of antibiotics that is recommended for treatment and prevention of bacterial respiratory disease in cattle and pigs. |
217500-96-4 |
DC20133 |
Tulrampator (CX-1632)
Tulrampator (CX-1632) is an orally bioavailable positive AMPAR (allosteric modulator of AMPA receptor). Antidepressant. |
1038984-31-4 |
DC21765 |
TVB-3166
Featured
TVB-3166 is an orally-available, reversible, potent, and selective fatty acid synthase (FASN) inhibitor with biochemical IC50 of 42 nM. |
1533438-83-3 |
DC9511 |
TVP1022
TVP1022 is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. |
185517-74-2 |
DC11435 |
Twincretin(Y3298176)
Twincretin(Y3298176) is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor dual agonist |
|
DC12480 |
TX1-85-1
Featured
TX1-85-1 is a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor with IC50 of 23 nM, forms a covalent bond with Cys721 located in the ATP-binding site of Her3. |
1603845-32-4 |
DC12479 |
TX2-121-1
TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor. |
1603845-42-6 |
DC24077 |
TY-52156
Featured
TY-52156 is a potent and selective inhibitor of S1P3 receptor (Ki=110 nM). |
934369-14-9 |
DC12344 |
Tyclopyrazoflor
Tyclopyrazoflor is an anthranilamide compound with pesticidal activity. |
1477919-27-9 |
DC20573 |
Tyk2-IN-30
TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3). |
1334407-95-2 |
DC8557 |
AG879
Featured
Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA. |
148741-30-4 |
DC9431 |
TZ9
Featured
TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM. |
1002789-86-7 |
DC12075 |
U18666A
Featured
U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. |
3039-71-2 |
DC7966 |
U73122
Featured
U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase). |
112648-68-7 |
DC11316 |
U-92016A
U-92016A is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 0.4 nM). |
149654-41-1 |
DC11245 |
UAB30
UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis. |
205252-59-1 |
DC12568 |
UBCS039
Featured
UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. |
358721-70-7 |
DC20574 |
UBE2M-DCN1 inhibitor 52
UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM. |
2089293-14-9 |
DCAPI1271 |
Ubenimex (Bestatin)
Featured
Bestatin is a natural, broad-spectrum, and competitive aminopeptidase inhibitor. |
58970-76-6 |
DC10298 |
Ubiquitin Isopeptidase Inhibitor I, G5
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. |
108477-18-5 |
DC21770 |
UBP 296
UBP 296 (UBP296, UBP-296) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 1.09 uM. |
745055-86-1 |
DC22151 |
Ubrogepant
Ubrogepant (MK-1602) is a novel potent, selective, oral calcitonin gene-related peptide receptor (CGRP) antagonist for acute treatment of migraine.. |
1374248-77-7 |
DC22644 |
UC-112
UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM. |
383392-66-3 |
DC12254 |
UC-1728
Featured
UC-1728 is a potent rabbit soluble epoxide hydrolase (sEH) inhibitor, with an IC50 of 2 nM on rabbit liver. |
948304-40-3 |
DC21771 |
UC-514321
Featured
UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
299420-83-0 |
DC23837 |
UCN-01
UCN-01 (7-Hydroxystaurosporine. |
112953-11-4 |
DC23583 |
UCPH-102
UCPH-102 is a selective, brain penetrant inhibitor of EAAT1 (Excitatory amino acid transporter 1) with IC50 of 420 nM. |
1229591-56-3 |
DC22467 |
UCS15A
UCS15A is a small moelcule SH3 domain-mediated protein-protein interaction blocking agent that inhibits proline-rich ligand-mediated protein-protein interactions (PLPI). |
108303-00-0 |
DC10942 |
UCT943
UCT943 (UCT-943) is a potent, selective, next generation Plasmodium falciparum PI4K inhibitor with IC50 of 23 nM. |
1450666-80-4 |
DC4133 |
Udenafil
Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED) |
268203-93-6 |
DC21778 |
UK 356618
UK 356618 is a potent and selective MMP3 inhibitor with IC50 of 5.9 nM, shows >140-fold less potent against MMP-1 (IC50=51000 nM), MMP-2 (IC50=1790 nM), MMP-9 (IC50=840 nM) and MMP-14 (IC50=1900 nM). |
230961-08-7 |
DC23684 |
UK-369003
UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6. |
334827-98-4 |
DC10350 |
UK-383367
UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs). |
348622-88-8 |
DC21775 |
UK-396082
UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI. |
400044-47-5 |
DC21779 |
UKH-1114
Featured
UKH-1114 (UKH1114) is a potent, sigma 2 receptor/Tmem97 agonist with Ki of 46 nM. |
2113664-14-3 |
DC4149 |
Ulinastatin
Ulinastatin (UTI) is a urinary trypsin inhibitor extracted and purified from urine of males. |
80449-31-6 |
DC12440 |
ULK-100
ULK-100 (ULK100) is a potent and selective ULK1 inhibitor with in vitro IC50 of 1.6 nM, inhibits ULK2 with IC50 of 2.6 nM. |
|
DC12805 |
ULK-101
Featured
ULK-101 is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM. |
2443816-45-1 |
DC20575 |
ULK1-IN-1
ULK1-IN-1 highly potent ULK1 inhibitor with IC50 of 8 nM, with no enough selectivity but sufficient potency, a cellular probe of autophagy.. |
1644063-60-4 |
DC7915 |
UNC0321
Featured
UNC0321 is a potent and selective G9a inhibitor with Ki of 63 pM, UNC0321 is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date.IC50 value: 63 pM(Ki); 9 nM (ECSD assay) [1]Target: G9aIt was found that replacing the 5- |
1238673-32-9 |
DC23217 |
UNC0379 trifluoroacetate
UNC0379 is a selective, +N2106:AC2106substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM, displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM). |
1620401-83-3 |
DC23859 |
UNC-1062
UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM. |
1350549-36-8 |
DC23847 |
UNC119
UNC119-Src interaction inhibitor 3 is a potent, specific small molecule inhibitor of UNC119-Src interaction with IC50 of 12 nM for displacement of the Src peptide from UNC119A. |
1358350-63-6 |
DC23861 |
UNC1666
UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM. |
1429882-12-1 |
DC23315 |
UNC-2170
UNC-2170 is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain. |
1648707-58-7 |
DC12510 |
UNC4203
UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM). |
1818234-19-3 |
DC11073 |
UniPR1331
UniPR1331 (UniPR-1331) is a selective, orally available antagonist of Eph/ephrin interaction with pIC50 of 5.45, IC50 of 2.9 uM. |
1809170-59-9 |
DC11197 |
UoS12258
Featured
UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6. |
875927-64-3 |
DC21781 |
UPCDC30245
Featured
UPCDC30245 is an allosteric inhibitor of AAA ATPase p97 with IC50 of 27 nM, binds at the junction between the D1 and D2 domains of p97.. |
1883351-01-6 |
DC11298 |
UPC-K-005
UPC-K-005 is a novel p38 inhibitor, exhibiting a IC50 of 13 μM. |
896842-60-7 |
DC21782 |
UPF1854
UPF1854 is a potent tankyrase inhibitor with IC50 of 12 nM and 200 nM for TNKS1 and TNKS-2 respectively, displays no cross-reactivity versus other PARP proteins. |
1569869-46-0 |
DC20183 |
UPGL00004
Featured
UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2. |
1890169-95-5 |
DC7335 |
URB-597
Featured
URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. |
546141-08-6 |
DC8130 |
URB754
URB754 is reported to be a potent, noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. |
86672-58-4 |
DC20166 |
Uridine 5'-monophosphate;Uridylic acid, 5'-Uridylic acid, Uridine phosphate, 5'-UMP, Uridine 5'-phosphoric acid
Uridine 5'-monophosphate is a nucleotide that is used as a monomer in RNA. |
58-97-9 |
DC20169 |
UTP, Trisodium Salt
Uridine-5'-triphosphate (UTP) is a pyrimidine nucleoside triphosphate and a substrate for the synthesis of RNA during transcription. |
19817-92-6 |
DC4151 |
Urofollitropin
Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified to remove various proteins and other substances. |
97048-13-0 |
DC22718 |
UR-PI376
UR-PI376 is a potent, selective histamine H4 receptor (hH4R) agonist with pEC50 of 7.47, shows negligible hH1R and hH2R activities and significant selectivity over the hH3R.. |
1192559-94-6 |
DC12340 |
Ursocholic acid
Ursocholic acid, a bile acid found predominantly in bile of mammals, is an inhibitor of 7α-hydroxysteroid dehydrogenase and hepatocyte nuclear factor 1α. |
2955-27-3 |
DC23800 |
USP10-IN-3
Featured
USP10-IN-3 is a HBX19818 analog, potent and selective USP10 inhibitor, but does not inhibit USP7 (IC50>100 uM). |
904448-58-4 |
DC23801 |
USP10-IN-9
USP10-IN-9 is a HBX19818 analog, selective USP10 inhibitor with IC50 similar to HBX19818, but does not inhibit USP7 (IC50>100 uM).. |
902281-60-1 |
DC11509 |
USP25 and 28 inhibitor AZ-2
USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively. |
2165322-95-0 |
DC7525 |
USP7-USP47 inhibitor
USP7/USP47 inhibitor is a potent and dual inhibitor of USP7/USP47 with IC50s of 0.42 uM(USP7) and 1.0 uM(USP47). |
1247825-37-1 |
DC12102 |
UT-155
Featured
UT-155 is a selective androgen receptor (AR) antagonist, with a Ki of 267 nM for AR-RBD. |
2031161-35-8 |
DC21041 |
UTL-5g
Featured
UTL-5g (GBL-5g) is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. |
646530-37-2 |
DC21785 |
UU-T01
UU-T01 is a novel small-molecule inhibitor of β-catenin/Tcf4 protein-protein interaction with Ki of 3.14 uM, binds to β-catenin with Kd of 0.531 uM.. |
1417162-83-4 |
DC21787 |
UU-T03
Featured
UU-T03 is the ethyl ester derivative of UU-T02, which is a potent, selective inhibitor of β-catenin/Tcf4 interaction with Ki of 1.36 uM; exhibits growth inhibition of SW480 cells with IC50 of 10.77 uM; downregulates the transcription of AXIN2, LGR5, cyclin D1, and c-Myc in dose-dependent manners in SW480 cells. |
1586007-00-2 |
DC21788 |
V-11-0711
V-11-0711 (V-11 0711) is a novel potent and selective choline kinase alpha (ChoKα) inhibitor with IC50 of 20 nM, with 11 fold less activity against ChoKβ. |
1428339-47-2 |
DC21789 |
V-116517
V-116517 is a novel potent, selective, oral bioavailable TRPV1 antagonist with IC50 of 35.1 nM. |
1073616-61-1 |
DC21790 |
VA-012
Featured
VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM. |
885898-58-8 |
DC12185 |
Vabicaserin hydrochloride (SCA 136)
Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM. |
887258-94-8 |
DC23239 |
Valacyclovir
Valacyclovir is an antiviral agent that acts as a very potent inhibitor of viral DNA polymerase. |
124832-26-4 |
DC7777 |
Valategrast (R411)
Valategrast (R411), a small molecule antagonist of α4β1 integrin, represents a potential therapy for asthma |
220847-86-9 |
DC12449 |
Valategrast hydrochloride
Valategrast hydrochloride is a potent, α4β1 (VLA-4) and α4β7 dual antagonist.. |
828271-96-1 |
DC8702 |
Val-cit-PAB-OH
Featured
Val-cit-PAB-OH is a peptide prodrug linker. |
159857-79-1 |
DC9405 |
Valdecoxib
Valdecoxib (SC 65872) is a COX-2 selective inhibitor with an IC50 value of 5 nM. |
181695-72-7 |
DC12217 |
O-Valeroyl-L-carnitine
Featured
Valerylcarnitine is an endogenous metabolite, belonging to the short-chain acylcarnitines. |
40225-14-7 |
DC9403 |
Valganciclovir (hydrochloride)
Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. |
175865-59-5 |
DC9729 |
Valrocemide (TV1901,VGD))
Featured
Valrocemide (TV1901,VGD)) has a broad spectrum of anticonvulsant activity and promising potential as a new AED. |
92262-58-3 |
DC8110 |
Valrubicin (AD-32)
Featured
Valrubicin (AD-32) is a chemotherapy drug used to treat bladder cancer. |
56124-62-0 |
DC12395 |
Vamorolone
Featured
Vamorolone (VBP-15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, alsp reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo. |
13209-41-1 |
DC8115 |
Vancomycin hydrochloride
Featured
Vancomycin hydrochloride in stock,price: 500 USD/100mg. 0 |
1404-93-9 |
DC24115 |
Vanoxerine
Vanoxerine (GBR-12909, I-893, Boxeprazine) is a highly potent inhibitor of dopamine uptake in vitro in tissue slices obtained from rat neostriatum with IC50 of 40-50 nM, also inhibits norepinephrine uptake with IC50 of 560-2600 nM. |
67469-69-6 |
DC20849 |
Vapendavir
Vapendavir (BTA798) is a novel potent enteroviral capsid binder, inhibits EV71 replication of all isolates with mean EC50 of 0.7 uM. |
439085-51-5 |
DC10348 |
Vapreotide acetate
Vapreotide acetate is a synthetic analog of somatostatin for the treatment of variceal bleeding; also exhibits antitumor activity. |
849479-74-9 |
DC10352 |
Varenicline Hydrochloride
Varenicline Hcl(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does. |
230615-23-3 |
DCJ-027 |
Varenicline tartrate
Featured
Varenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does. |
375815-87-5 |
DC7607 |
Vatalanib
Featured
Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. Phase 1/2. |
212141-51-0 |
DC8655 |
Vatalanib free base
Vatalanib free base (PTK787 free base) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. |
212141-54-3 |
DC22255 |
VB-82252
VB-82252 is a highly potent, orally active inhibitor of C. difficile toxins TcdA and TcdB, potently inhibits UDP glucose hydrolysis activity of TcdB (IC50=32 nM). |
2170004-34-7 |
DC11168 |
VCE-004.3
VCE-004.3 (VCE004.3) is a novel semi-synthetic cannabidiol derivative behaving as a dual PPARγ/CB2 agonist and CB1 receptor modulator, binds and activates PPARγ (IC50=3.5 uM) and CB2 receptors (pKi=6.69) and antagonizes CB1 receptor (pKi=5.61). |
1818428-14-6 |
DC4236 |
VCH-916
VCH-916 is a novel allosteric inhibitor of HCV NS5B polymerase. The RNA-dependent RNA polymerase (NS5B) of HCV is one of the attractive validated targets for development of new drugs to block HCV infection. |
1200133-34-1 |
DC20578 |
VDR 4-1
VDR 4-1 is a novel non-steroidal, small-molecule agonist of vitamin D receptor (VDR). |
303203-28-3 |
DC23860 |
Vecabrutinib
Vecabrutinib (SNS-062) is a potent, reversible, non-covalent BTK inhibitor with IC50 of 2.9 and 4.4 nM for WT BTK and C481S BTK, respectively. |
1510829-06-7 |
DC21368 |
VEL-0230
VEL-0230 (NC-2300) is a potent, selective cysteine Cathepsins inhibitor with IC50 of 284, 34.5 and 186 nM for Cat B, K and S, respectively. |
221144-20-3 |
DC21743 |
Velusetrag
Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7, shows >500-fold selectivity over other 5-HT receptors. |
866933-46-2 |
DC21744 |
Velusetrag hydrochloride
Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7, shows >500-fold selectivity over other 5-HT receptors. |
866933-51-9 |
DC5881 |
Venlafaxine Hydro Chloride
Venlafaxine Hydrochloride is a dual ST and SLC6A2 (serotonin and noradrenalin re-uptake) inhibitor that displays ~ 30-fold higher affinity for ST (SERT) (Ki = 82 nm) than SLC6A2 (NET) (Ki = 2480 nM). |
99300-78-4 |
DC7737 |
VER-50589
VER-50589 is a potent HSP90 inhibitor with IC50 of 21 nM for HSP90β. |
747413-08-7 |
DC7880 |
CP 16533-1 (Verapamil)
Verapamil is a CYP3A inhibitor. |
52-53-9 |
DC9571 |
Veratramine
Veratramine(NSC17821; NSC23880) is useful as a signal transduction inhibitor for treating tumors. |
60-70-8 |
DC20742 |
Vericiguat (BAY 1021189)
Featured
Vericiguat (BAY 1021189) is a novel potent, selective, orally available soluble guanylate cyclase (sGC) stimulator (MEC=0.3 uM), stimulating sGC NO-independently and in synergy with NO. |
1350653-20-1 |
DC9599 |
Vernakalant (Hydrochloride)
Vernakalant Hcl(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. |
748810-28-8 |
DC11225 |
sabizabulin(VERU-111)
Featured
VERU-111 (Sabizabulin) is a novel potent colchicine binding site inhibitor (CBSI) in tubulin with potential anticancer activities. Sabizabulin is a novel oral agent with both anti-viral and anti-inflammatory activities.Sabizabulin is a cytoskeleton disruptor which by causing microtubule depolymerization has both anti-viral and anti-inflammatory activity and could be effective against the SARS-CoV-2 virus by disrupting its intracellular transport along the microtubules. Microtubule trafficking is critical for viruses to be transported, replicated, assembled, and released from the cell. In addition, microtubule depolymerization drugs that target the “colchicine binding site” of microtubules, like sabizabulin, also have strong anti-inflammatory effects, including the potential to treat the cytokine release syndrome (cytokine storm) and septic shock induced by the SARS-CoV-2 viral infection that is associated with high COVID-19 mortality rates. |
1332881-26-1 |
DC11227 |
VERU-111 analogue 13f
VERU-111 analogue 13f is a novel potent colchicine binding site inhibitor (CBSI) in tubulin with potential anticancer activities. |
|
DC22423 |
Vestipitant
Vestipitant (GW597599) is a potent, selective, orally active NK1 receptor antagonist with pKi of 9.65. |
334476-46-9 |
DC22417 |
Vestipitant mesylate
Vestipitant (GW597599) is a potent, selective, orally active NK1 receptor antagonist with pKi of 9.65. |
334476-64-1 |
DC26108 |
VGSC blocker 1
VGSC blocker 1 is a potent, small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5), blocks INa peak currents 34.9% at 1 uM. |
|
DC21967 |
VGTI-A3-03
VGTI-A3-03 is a novel potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM), directly bind DENV capsid protein. |
|
DC11579 |
VH032
Featured
VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.. |
1448188-62-2 |
DC26127 |
VHL ligand 1 (TFA)
VHL ligand 1 TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. |
1631137-51-3 |
DC26119 |
VHL ligand 2 hydrochloride
Featured
VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. |
1948273-03-7 |
DC21968 |
VHL-alkyne
VHL-alkyne is a VHL ligand for PROTAC synthesis.. |
|
DC20579 |
VHL-IN-15
VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.. |
1360616-29-0 |
DC9560 |
Vigabatrin (Hydrochloride)
Vigabatrin Hcl(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. |
1391054-02-6 |
DC9541 |
Vigabatrin
Featured
Vigabatrin(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase. IC50 value: Target: GABA transaminase Clinical studies have sh |
68506-86-5 |
DC20741 |
Vilaprisan
Vilaprisan (BAY 1002670) is a highly potent and selective progesterone receptor (PR) modulator. |
1262108-14-4 |
DC5016 |
Vilazodone hydrochloride
Vilazodone (EMD 68843) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation. |
163521-08-2 |
DC7712 |
Vilazodonei
Vilazodone is an inhibitor of ST (serotonin transporter and uptake) (IC50 = 0.5 nM) and SR-1A activator (partial agonist) (IC50 = 0.2 nM; IA = ~60-70%). |
163521-12-8 |
DC23236 |
Vinpocetine
Vinpocetine (Ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine, selectively inhibits PDE1 in isolated rabbit aorta with IC50 of 21 uM. |
42971-09-5 |
DC12559 |
VinSpinIn
VinSpinIn is a potent, cell active chemical probe for the Spin family protein with Kd of 10-130 nM for across the family, displays >300-fold selectivity over a panel of methyltransferases. |
|
DC12716 |
VIS351
VIS351 (VIS-351) is a potent activator of the immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated function of the IDO1 enzyme with Kd of 1.9 uM. |
397882-20-1 |
DC6503 |
Vitamin B12
Vitamin B12 is a water-soluble vitamin with roles in brain and nervous system functioning and blood formation through regulation of DNA synthesis, cellular metabolism, fatty acid metabolism, and amino acid metabolism. |
68-19-9 |
DC22256 |
VK-1727
VK-1727 (VK1727) is a small-molecule inhibitor of the DNA binding activity of EBNA1 (Epstein-Barr nuclear antigen1). |