SJB7 is a close analog of SPA70 and hPXR agonist, interacts with the ligand-binding domain (LBD) of hPXR..

SK 216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM.

SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation.

SKA-121 is a positive-gating modulator of intermediate-conductance calcium-activated potassium channels (IKCa1/KCa3.1) with an EC50 value of 109 nM using whole-cell patch-clamp electrophysiology with calcium in the internal solution.

Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.

SKF 82958 hydrobromide is a D1/D5 receptor full agonist.

SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.

SKF-38393 is a potent, selective D1/D5 receptor partial agonist with Ki of 1 and 0.5 nM, respectively.

SKF-89976A was used to study the role of adenosine receptors in uptake of GABA transport.

SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM).

SKLB1002 is a novel and potent VEGFR-2 inhibitor with an IC50 value of 32 nM.

SKLB188 is a novel multikinase inhibitor and potently inhibits EGFR with IC50 of 5 nM.

SKLB-C05 is a novel selective, orally active TOPK inhibitor with IC50 of 0.5 nM, shows excellent cytotoxicity and anti-migration and invasion activity on TOPK high-expressing CRC cells and induces cell apoptosis.

SL 0101-1 is a selective inhibitor of p90 Rsk (ribosomal S6 kinase) (IC50 = 89 nM for Rsk-2).

SLC25A20-IN-21 is a SLC25A20 ligand that increases long-chain (>C14) acylcarnitine content and reduces maximal exogenous fatty acid oxidation in HSC-5 cells.

SLLK, Control Peptide for TSP1 Inhibitor (TFA) is a control peptide for LSKL, which is a Thrombospondin (TSP-1) inhibitor.

SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation and .

SM-1295 is a potent, selective cIAP1 and cIAP2 inhibitor with Ki of <10 nM, displays >900-fold for cIAP1 over XIAP.

SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.

SM253 (SM 253, SM-253) is a novel potent Hsp90 inhibitor that does not induce heat shock response.

SM-324405 is a potent, selective TLR7 agonist with EC50 of 50 nM, induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, inhibits IL-5 production in human PBMCs in vitro..

SMAP-2 (DT-1154) is an orally bioavailable small molecule activator of PP2A, binds to PP2A Aα scaffold subunit and inhibits KRAS-driven tumor growth both in vitro and in vivo.

SMARt-420 (BDM 41420) is a small molecule that can fully reverses ethionamide-acquired resistance and clears ethionamide-resistant M. tuberculosis infection in mice, also increases the basal sensitivity of bacteria to ethionamide..

SMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo.

SMIFH2 is a small molecule formin homology 2 domains inhibitor of formin-mediated actin assembly, targets formins from evolutionarily diverse organisms including yeast, nematode worm, and mice with IC50s of 5-15 uM.

SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, it was found to downregulate SKP2 and to stabilize p27.

SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM.

SMN-C2 is a close analogs of RG-7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing.

SMN-C3 is a selective, orally available small molecule SMN2 splicing modifier toward the production of full-length SMN2 messenger RNA with high selectivity.

SMND-309 is a novel derivative of salvianolic acid B, and has shown protective effects against rat cortical neuron damage in vitro and in vivo.

Smo antagonist M25 is a potent Smoothened (Smo) receptor antagonist (IC50=5 nM) that inhibits the Hedgehog signaling pathway.

Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.

SMU127 (SMU-127, ZINC666243) is a specific TLR1-TLR2 small molecule agonist with EC50 of 0.55 uM.

SN 2 is a novel and potent small molecule activator of TRPML3 with EC50 of 1.13 uM.

SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively.

SN79 dihydrochloride (Sigma receptor ligand SN79) is a putative σ receptor antagonist with nanomolar affinity and selectivity for σ receptors over 57 other binding sites.

SNAP-7941 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 15 nM.

SNAP-94847 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 1.69 nM.

SNAP-94847 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 1.69 nM.

SNIPER(ABL)-062 is a novel, potent SNIPER molecule that tethers BCR-ABL inhibitor to a ligand of IAP, causes potent BCR-ABL degradation.

SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker.

SNIPER(ER)-110 is a nongenetic IAP-dependent protein eraser (SNIPER) targeting estrogen receptor α (ERα), induces ERα degradation and induces apoptosis in MCF-7 human breast cancer cells.

SNVP is an S-nitrosothiol that acts as a nitric oxide (NO) donor and vasodilator.

SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.

SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.

SNX-9114 (SNX9114, PF-04944733) is a small molecule Hsp90 inhibitor with excellent brain permeability..

Sobetirome(GC-1; QRX-431) is a member of a class of compounds known as selective thyromimetics.

SOD1-Derlin-1 inhibitor 56-59 is a cell-permeable, small molecule inhibitor of SOD1-Derlin-1 interaction, target SOD1 DBR and clearly attenuates the interactions of Derlin-1 with 122 types of SOD1mut in the cell-based co-immunoprecipitation assay.

sodium 4-pentynoate is a alkynylacetate analogue; can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types.

Sodium channel blocker. Suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Antinociceptive; displays analgesic effects in animal models of inflammatory and neuropathic pain.

Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.

Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent.

Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion.

Sodium Sulfadiazine is a sodium salt form of sulfadiazine, an intermediate-acting bacteriostatic, synthetic sulfanilamide derivative.

Sortin1 is a small molecule sorting inhibitor (Sortin) that induces reversible defects in vacuole biogenesis and root development in Arabidopsis seedlings at 100 mg/liter (227 uM).

SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro.

Sotrastaurin(AEB-071) is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM; inactive to PKCζ.

Sovaprevir (ACH-1625, ACH-0141625) is a potent HCV NS3/4A inhibitor in development for the treatment of hepatitis C..

SP 141 is a cell-permeable inhibitor of Mdm2 (Ki = 28 nM).

SP 4206 is a high-affinity (Kd=70 nM) small molecule that blocks blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2.

SP2509 is a novel histone demethylase LSD1 (KDM1A) antagonist with IC50 of 13 nM; no inhibition on MAO-A and MAO-B.

SPA70 is a potent and selective hPXR antagonist (IC50=0.51 uM) that interacts with the ligand-binding domain (LBD) of hPXR, inhibits hPXR in human hepatocytes and mouse models and enhances the chemosensitivity of cancer cells.

SPACE peptide is a skin penetrating peptide which facilitates the delivery of molecules through the skin.

SPD304 is a selective inhibitor of tumor necrosis factor α (TNFα) and promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor, with an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α.

SPDB is a disulfide chemical linker for antibody-drug conjugates (ADCs)..

Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC50 = 0.5 μM).

Sphynolactone-7 (SPL7) is a potent, specific, femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica with minimum effective concentration (MEC) of 10 fM that produces any seed germination.

Sphynolactone-7 (SPL7) is a potent, specific, femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica with minimum effective concentration (MEC) of 10 fM that produces any seed germination.

SPI009 is a novel antipersister compound active against P. aeruginosa.

Spiradoline (U 62066) is a potent, highly selective κ-opioid agonist that has analgesic diuretic and antitussive effects..

Spiradoline (U 62066) is a potent, highly selective κ-opioid agonist that has analgesic diuretic and antitussive effects..

Spirodiclofen is a broad spectrum acaricide acting via lipid biosynthesis inhibition (LBI) with no cross resistance to currently available acaricides and with additional insecticidal properties.

Spiropiperidine 1 (SPP1)i s a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.

Spiropiperidine 1 (SPP1)i s a potent, functionally selective and brain penetrant M1 orthosteric agonist with Ki of 21.3 nM for hM1 receptors.

SPK-601(LMV-601) is a potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor; SPK-601 is useful antimicrobial agent.

SPL-707 (SPL707) is the first selective, orally active signal peptide peptidase-like 2a (SPPL2a) inhibitor with IC50 of 77 nM, shows 25-fold selectivity over γ-secretase and SPP.

sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively.

Spliceostatin A is a methylated derivative of FR-901464 that inhibits pre-mRNA splicing.

Splitomicin is a derivative of β-naphthol is an inhibitor of Silent Information Regulator 2 (SIR2).

SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP).

SPR-00305 is a potent MvfR inhibitor and displays target engagement.

SPRi3 (SPR inhibitor 3) is a small molecule inhibitor of sepiapterin reductase (SPR) with IC50 of 74 nM in cell-free assays, efficiently reduces biopterin levels with IC50 of 5.2 uM.

SPV 106 is the first mixed activator/inhibitor of Histone acetyltransferases (HATs), potentiates p300/CBP-associated factor (PCAF) HAT activity while inhibiting those of p300/CBP and recombinant CBP.

SPX-101 is a specific, peptide mimetic promoter of epithelial sodium channel (ENaC) internalization, binds selectively to ENaC and promotes internalization of the α-, β-, and γ-subunits.

Squalene epoxidase inhibitor. Suppresses triglyceride biosynthesis through the farnesol pathway.

SR 16832 is a dual-site covalent antagonist of peroxisome proliferator-activated receptor γ (PPARγ).

SR 48692 is a neurotensin antagonist; selective for NTS1 over NTS2 (apparent affinity, Ke, is 36 nM for NTS1). Competitively inhibits binding of [125I]-neurotensin to HT29 and N1E115 cell membranes (IC50 values are 15.3 and 20.4 nM respectively).

SR 9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK with IC50 of 12 nM and 99 nM respectively.

SR1001 is a high-affinity synthetic ligand of RORα and RORγ; suppresses TH17 cell differentiation and inhibits autoimmunity.

SR1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ.

SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays.

SR12460 (SR-12460) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 20.24 uM.

SR146131 (SR-146131) a small molecule positive allosteric modulator of the type 1 cholecystokinin receptor (CCK1R) with pEC50 of 10.34..

SR1555 is a selective RORγ inverse agonist (IC50=1.5 uM) that suppresses T(H)17 cells and stimulates T regulatory cells.

SR-16430 is a selective ORL1 receptor (NOP receptor) antagonist that has 10-fold selectivity over μ-opioid receptor..

SR-16435 is a mixed NOP/μ-opioid partial agonist with equally high affinity (Ki=29 nM) for both NOP and μ-opioid receptors.

SR-16835 is a potent full agonist of ORL1 receptor (NOP receptor) with binding Ki of 11.4 nM, with low-affinity mu-opioid partial agonist activity (Ki=79.9 nM).

SR-20295 (SR20295) is a novel potent ULK1 inhibitor with IC50 of 45 nM..

SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells.

SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM.

SR-3306 is a highly selective, brain penetrant, potent inhibitor of JNK with IC50 of 67, 283 and 159 nM for JNK1, JNK2 and JNK3, >100-fold selectivity over p38.

SR3335 (ML-176) is a selective RORα synthetic ligand, directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays.

SR-57227 is a high affinity, selective 5-HT3 receptor agonist, demonstrates anticonvulsant effects in vivo..

SR-57227 is a high affinity, selective 5-HT3 receptor agonist, demonstrates anticonvulsant effects in vivo..

SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM, displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold).

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.

SRI-31142 (SRI31142) is a novel potent, putative allosteric dopamine transporter (DAT) inhibitor with Ki of 1.9 nM..

SRPIN-803 (SRPIN 803, SRPIN803) is a novel small molecule dual inhibitor of SRPK1 and CK2 with IC50 of 2.4 uM and 0.2 uM, respectively, does not inhibit SRPK2.

SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect.

SRT 2183 is a potent, selective SIRT1 activator with EC1.5 of 0.36 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.

SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol.

SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay.

SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay.

SSD114 is a novel GABAB positive allosteric modulator.

SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist, shows anxiolytic- and antidepressant-like activities in vivo. .

SSR411298 is a highly selective, brain penetrant and orally-active inhibitor of FAAH with IC50 of 62.5 nM (mouse brain FAAH).

SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM.

ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein.

ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively.

ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.

ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.

ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A2A receptor, with Kis of 8 nM and 33 nM for A2A and A1 receptors, respectively.

ST-836 Hcl is a dopamine receptor ligand; Antiparkinsonian agent.

STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90.

Stachyose is a prebiotic, a non-reducing tetrasaccharide in the rafnose family of oligosaccharides with few side efects.

Stafib-2 (Stafib 2) is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 9 nM, >20-fold selectivity over STAT5a..

STAT5b inhibitor 7 (Capstafin prodrug) is the pivaloyloxymethyl ester prodrug of Capstafin, which is a potent, selective STAT5b inhibitor with Ki of 0.34 uM.

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1.

STD-101-D1 is a novel brain permeable, G protein-biased beta-1 adrenergic receptor (ADRB1) partial agonist with EC50 of 16.9 nM.

STD1T (USP2a inhibitor STD1T) is a hit-to-lead, small-molecule inhibitor of USP2a with IC50 of 3.3 uM in Ub-AMC assays, displays no activity against USP7 at 10 uM.

Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.

Stearoylcarnitine is a fatty ester lipid molecule.

Stibogluconate sodium (Sodium stibogluconate) is a multiple antimony compound that has leishmanicidal and potential antineoplastic activities, inhibits protein tyrosine phosphorylase SHP-1 (99% inhibtion at 10 ug/mL), SHP-2 and PTP1B, shows anticancer act

STIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro, induces expression of p53 target proteins and triggers apoptosis in mutant p53-expressing human tumor cells..

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.

STING agonist 4 is an amidobenzimidazole (ABZI)-based compound that functions as a STING agonist with Kd of 1.6 nM (binding of endogenous full-length STING, THP-1 cell lysates); caused dose-dependent phosphorylation of IRF3 and STING that was inhibited by the TBK1 inhibitor BX795, induced dose-dependent secretion of IFN-β with EC50 of 3.1 uM in PBMCs (18-fold more potent than cGAMP); promotes production of IFN-γ-induced protein 10 (IP-10), IL-6 and TNFα by a mechanism that is dependent on STING-mediated activation of TBK1; unlike cGAMP and DMXAA, compound 2 efficiently activates STING function while maintaining an open STING confirmation.

diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

STING CDN agonist IFM Therapeutics is a synthetic cyclic dinucleotide (CDN) agonist of STING, stimulates potent immunity against cancer..

Streptonigrin (Bruneomycin, NSC 45383) is a potent, selective, and irreversible PAD4 inactivator with IC50 of 1.87 uM, also binds directly to RAD54 with Kd of 9.1 uM, inhibits ATPase and DNA branch migration activity of RAD54.

S-Trityl-L-cysteine (NSC 83265) is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, inhibits basal ATPase activity (IC50=1 mM) and microtubule-activated ATPase activity of Eg5 (IC50=140 nM).

SU 16f is a potent and selective PDGFRβ inhibitor with IC50 of 10 nM, displays >14-fold, >229-fold and >10,000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively.

SU-10994 is a novel VEGFR inhibitor.

SU-11752 is a potent, selective inhibitor of DNA-PK, >500-fold selectivity over PI3Kγ, inhibits DNA double-strand break repair in cells and sensitizs ionizing radiation in cancer cells..

SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3).

SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway.

Suberohydroxamic acid is a competitive HDAC inhibitor with IC50 values of 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively.

Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.

Suc-AAP-Abu-pNA is a chromogenic peptide substrate for pancreatic elastase.It is cleaved by elastase to release p-nitroalinide (p-NA), which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity.

Sucralfate is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus

Sudemycin E is an alternative splicing inhibitor that binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1, causes a rapid change in alternative pre-messenger RNA splicing.

Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM.

Sufugolix(TAK-013) is a non-peptide, orally-active, selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (IC50 = 0.1 and 0.06 nM for affinity and in vitro inhibition, respectively).

Sulfabenzamide is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of an

Sulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively.

Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.

Sulisobenzone is an ingredient in some sunscreens which protects the skin from damage

Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.

Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam.

Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.

Surfen hydrate is a small molecule antagonist of heparan sulfate, binds to heparin, low molecular weight heparins, and to HS and other GAGs.

Surfen is a small molecule antagonist of heparan sulfate, binds to heparin, low molecular weight heparins, and to HS and other GAGs.

SUVN-502 (SUVN502) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM.

SUVN-502 (SUVN502) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM.

SUVN-502 (SUVN502, Masupirdine) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM.

SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).

SW-034538 is a potent TAOK2 (Thousand-And-One Kinase 2.

SW063058 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity..

SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.

SW-100 (SW100) is a potent, selective, brain penetrable HDAC6 inhibitor with IC50 of 2.3 nM, displays >1,000-fold selectivity over all other class I, II, and IV HDAC isoforms.

Gliocidin is a prodrug that is anabolized into its tumoricidal metabolite, gliocidin–adenine dinucleotide (GAD). Gliocidin kills glioblastoma cells while sparing non-tumour replicative cells. Gliocidin activity targets a de novo purine synthesis vulnerability in glioblastoma through indirect inhibition of inosine monophosphate dehydrogenase 2 (IMPDH2). Gliocidin penetrates the blood–brain barrier and extends the survival of mice with orthotopic glioblastoma.

SW-163D-AcLysValCit-PABC-DMAE is a Drug-Linker Conjugates for ADC which consists of a natural bis-intercalator, SW-163D, conjugated via an AcLysValCitPABC-DMAE linker.

SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C.

Syk-IN-23 is a potent, selective Syk kinase inhibitor with IC50 of 20 nM, possesses good PK in both rat and dog and demonstrated efficacy in rat CIA model..

SYM2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50 = 2.8 μM ).

Syn-TEF1 intermediate 1 is a chemcal intermediate for Syn-TEF1 synthesis, which is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia..

Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci.

SynuClean-D (SC-D) is a novel, small molecule inhibitor of α-synuclein (α-Syn) aggregation, incubation of 70 uM α-Syn with 100 uM SC-D impacted α-Syn aggregation in vitro, as monitored by Th-T fluorescence.

SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.

T0070907 is a potent and selective PPARγ antagonist with IC50 of 1 nM; displays > 800-fold selectivity for PPARγ over PPARα and PPARδ.

T-025 (T025, CLK inhibitor T-025) is an orally available, potent inhibitor of Cdc2-like kinases (CLKs) with Kd of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, also inhibits DYRK1A and DYRK1B with IC50 of 0.074 and 1.5 nM.

T-1105 is a broad-spectrum antiviral inhibitor that demonstrates good activity for various RNA viruses, including influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV), FMDV, and ZIKV.

T1551 is a novel selective PRMT5 inhibitor with IC50 of 34.1 uM, decreases cell viability of A549 cell with IC50 of 5.8 uM (72h).

T-155535 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 21 uM in AlphaScreen assay.

T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM; T16Ainh-A01 (1-30 uM) inhibited single calcium (Ca2+)-activated chloride (Cl−) channels and whole cell currents activated by 500 nM free Ca2+; T16Ainh-A01 relaxed mouse thoracic aorta pre-contracted with methoxamine with an IC50 of 1.6 uM and suppressed the methoxamine concentration-effect curve; blocks calcium-activated chloride channels in vascular smooth muscle cells and relaxes murine and human blood vessels.

T-1840383 is a potent, ATP-competitive, dual c-Met/VEGFR-2 inhibitor with IC50 of 1.9, 7.7, 2.2 and 5.5 nM for c-Met, VEGFR1, 2 and 3, respectively.

T-226296 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with IC50 of 5.5 nM and 8.6 nM for human and rat MCHR1, respectively.

T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes.

T-3764518 (T 3764518, T3764518) is a novel potent, orally active SCD1 inhibitor with binding IC50 of 4.7 nM for hSCD1.

T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.

T-3861174 is a novel small molecule prolyl tRNA synthetase (PRS) with binding IC50 of 2.3 nM.

T3D 959 (DB-959) is a potent, brain penetrant, orally active dual PPARδ/PPARγ agonist with EC50 of 19/297 nM, respectively.

T-448 free base (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts.

T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3.

T5342126 hydrochloride is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.

T5342126 is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.

T5910047 (T-5910047) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM.

T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.

Tadalafil is a potent and selective inhibitor of Phosphodiesterase-5 (PDE5) This compound prevents the breakdown of phosphodiesterases, many of which are used as secondary messengers. By preventing the breakdown of these messenger molecules, tadalafil can

Tafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum..

Tafenoquine succinate (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum..