VER-50589|VER50589|Purchase|DC CHEM

Cas No.:	747413-08-7
Synonyms:	VER 50589,VER50589
SMILES:	O=C(C1=NOC(C2=CC(Cl)=C(O)C=C2O)=C1C3=CC=C(OC)C=C3)NCC
Formula:	C₁₉H₁₇ClN₂O₅
M.Wt:	388.8
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

VER-50589 inhibits the intrinsic ATPase activity of recombinant yeast Hsp90 with IC50 of 143 nM, and produces antiproliferative activity in a panel of human cancer cell lines and nontumorigenic cells in vitro. VER-50589 causes induction of HSP72 and HSP27 alongside depletion of client proteins, including C-RAF, B-RAF, and survivin, and the protein arginine methyltransferase PRMT5, which further result in cell cycle arrest and apoptosis. In HCT116 human colon cancer xenografts, VER-50589 (100 mg/kg i.p.) results in a statistically significant reduction of ∼30% in tumor volume and weight, as well as induction of HSP72 and depletion of ERBB2 and C-RAF. . For the detailed information of VER-50589, the solubility of VER-50589 in water, the solubility of VER-50589 in DMSO, the solubility of VER-50589 in PBS buffer, the animal experiment (test) of VER-50589, the cell expriment (test) of VER-50589, the in vivo, in vitro and clinical trial test of VER-50589, the EC50, IC50,and affinity,of VER-50589, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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