Cat. No. | Product name | CAS No. |
DC22551 |
DFMTI
A potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively. |
864864-86-8 |
DC22895 |
VU0477573
A potent, selective, brain penetrant partial negative allosteric modulator of mGlu5 receptor with Ki of 14 nM, Ca assay IC50 of 32 nM. |
1946021-40-4 |
DC22964 |
PQ-10
Featured
A potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM. |
927691-21-2 |
DC11660 |
PF-4181366
A potent, selective, brain penetrant PDE9A inhibitor with IC50 of 1.8 nM. |
1082743-32-5 |
DC23695 |
PF-05085727
A potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11. |
1415637-72-7 |
DC22920 |
AMN 082 dihydrochloride
A potent, selective, brain penetrant, orally acitve mGluR7 allosteric agonist that inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64±32 nM. |
97075-46-2 |
DC23640 |
ASP2535
A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2. |
374886-51-8 |
DC11895 |
Foliglurax hydrochloride
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
2133294-96-7 |
DC11894 |
Foliglurax
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
1883329-51-8 |
DC20549 |
SHP2 inhibitor 11a-1
A potent, selective, cell active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs. |
1620746-09-9 |
DC11948 |
CK2 inhibitor D11
A potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM. |
1803427-24-8 |
DC11858 |
BAY-678
Featured
BAY-678 is a cell-permeable inhibitor of human neutrophil elastase (HNE). |
675103-36-3 |
DC22877 |
CPI703
A potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP. |
1904649-00-8 |
DC25052 |
Src I338G-IN-3g
A potent, selective, cell-permeable I338G v-Src inhibitor with IC50 of 430 nM, shows no inhibition of wild-type v-Src at 300 uM. |
206991-94-8 |
DC21474 |
PF-04781340
A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability. |
1648726-56-0 |
DC22708 |
VU 0255035
A potent, selective, CNS penetrant and competitive orthosteric antagonist of M1 mAChR with IC50 of 132 nM, >75-fold selectivity over M2-M5. |
1135243-19-4 |
DC22667 |
mGlu5 PAM 4k
A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM. |
1382782-16-2 |
DC22684 |
JNJ-46778212
Featured
A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM. |
1363281-27-9 |
DC11558 |
DLK-IN-14
A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM. |
1620574-24-4 |
DC11870 |
RORγt-IN-9a
A potent, selective, CNS penetrant, orally bioavailable RORγt with pIC50 of 8.3 in FRET assays. |
1426803-07-7 |
DC22730 |
JNJ-42253432
A potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively. |
1428327-35-8 |
DC22903 |
SW-106
Featured
SW106 is a potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM. |
1027921-53-4 |