| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC20625 | ABT-072 | ABT-072 is a novel, orally bioavailable non-nucleoside HCV NS5B polymerase inhibitor with EC50 of 0.3 nM (GT1b). |
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| DC22258 | ABT-080 | ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM. |
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| DC20626 | ABT-089 | ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM. |
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| DC21984 | ABT-100 | ABT-100 (ABT100) is a highly selective, potent, orally bioavailable inhibitor of farnesyltransferase (FTase). |
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| DC20628 | ABT-102 | ABT-102 is a potent, highly selective, orally active TRPV1 antagonist that inhibits agonist-evoked increases in intracellular Ca(2+) levels with IC50 of 5-7 nM. |
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| DC20629 | ABT-107 | ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs. |
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| DC23537 | ABT-288 | ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively. |
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| DC4231 | Linifanib (ABT-869) Featured | ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) receptor families. |
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| DC20630 | ABTL0812 | ABTL0812 is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells. |
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| DC23182 | ABX464 Featured | ABX464 (ABX-464, ABX 464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM. |
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| DC11508 | AC1903 Featured | AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model. |
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| DC10293 | AC260584 | AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6. |
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| DC11149 | AC261066 | AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3). |
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| DC20631 | AC-265347 | AC-265347 is a calcimimetic acting agent and highly efficacious, orally active allosteric agonist (PAM) of CaSR with IC50 of 10 nM in PI hydrolysis assays. |
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| DC20300 | AC-4-130 | AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. |
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| DC21863 | AC5 inhibitor C90 | AC5 inhibitor C90 is a novel potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes. |
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| DC12086 | AC-55649 Featured | AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9. |
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| DC7700 | AC710 Featured | AC710, is a potent Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. |
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| DC11359 | Caspase-3 Substrate | Ac-DNLD-AMC is a fluorogenic caspase-3 substrate. |
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| DC9900 | Acetaminophen Featured | Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. |
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| DC20115 | Acetoacetic acid sodium salt | Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. |
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| DC10248 | Acetohydroxamic acid | Acetohydroxamic acid is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease. |
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| DC20151 | Acetosyringone Featured | Acetosyringone is a phenolic compound from wounded plant cells, enables virA gene which encodes a membrane-bound kinase to phosphorylate itself and activate the virG gene product, which stimulates the transcription of other vir genes and itself. Acetosyri |
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| DC12151 | Acetyl Perisesaccharide C | Acetyl Perisesaccharide C is an oligosaccharide, which is isolated from the root barks of Periploca sepium. |
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| DC9894 | Acetylcholine iodide | Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. |
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| DC10637 | Acetylspiramycin (ASPM) | Acetylspiramycin (ASPM) is a macrolide antimicrobial agent. |
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| DC21985 | Ac-IEPD-CHO | Ac-IEPD-CHO is a potent, reversible inhibitor of serine protease Granzyme B (GzmB) with Ki of 80 nM, also inhibits caspase-7 (Ki=550 nM) and induces apoptosis.. |
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| DC11350 | Caspase-8 Chromogenic Substrate I | Ac-IETD-pNA is a substrate for caspase-8. |
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| DC1092 | Acitazanolast (WP-871,Zepelin) | Acitazanolast is an active metabolite of tazanolast and anti-allergic drug. |
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| DC22805 | (R)-9b | Ack1 inhibitor (R)-9b is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM. |
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