Cat. No. | Product name | CAS No. |
DC41788 |
PL-017 TFA
PL-017 TFA is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 TFA produces long-lasting, reversible analgesia in rats. |
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DC41867 |
Dynorphin A (1-8)
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM). |
75790-53-3 |
DC42314 |
EST73502
Featured
EST73502 is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 has antinociceptive activity. |
1838622-25-5 |
DC42315 |
Cebranopadol ((1α,4α)stereoisomer)
Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol. Cebranopadol is a potent agonist activity on ORL-1. |
863513-93-3 |
DC44147 |
UFP-101 TFA
UFP-101 TFA is a potent, selective, and competitive antagonist of the NOP receptor, with a pKi of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect. |
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DC44749 |
6'-GNTI dihydrochloride
6'-GNTI dihydrochloride, a κ-opioid receptor (KOR) agonist, displays bias toward the activation of G protein-mediated signaling over β-arrestin2 recruitment. 6'-GNTI 6'-GNTI dihydrochloride only activates the Akt pathway in striatal neurons. |
2410327-94-3 |
DC44976 |
LY2940094 tartrate
LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models. |
1307245-87-9 |
DC45524 |
Deltorphin 2 TFA
Deltorphin 2 TFA is a selective peptide agonist for the δ opioid receptor. |
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DC45572 |
Nociceptin (1-13), amide TFA
Nociceptin (1-13), amide TFA is a potent ORL1 receptor (opioid receptor-like 1 receptor, OP4) agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes. |
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DC45826 |
BMS-986121
BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor extracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs. |
313671-26-0 |
DC46495 |
DIPPA hydrochloride
DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant. |
155512-52-0 |
DC46693 |
DAMGO
Featured
DAMGO (DAGO) is a potent and selective μ opioid receptor agonist with ki of 17 nM. |
78123-71-4 |
DC47074 |
Sunobinop
Sunobinop (S 117957) is a modulator of the opioid receptor-like orphan receptor (ORL1). |
1126793-40-5 |
DC47541 |
SC13
SC13 is a novel mitragynine analog with low-efficacy Mu opioid receptor agonism that displays antinociception with attenuated adverse effects. |
|
DC48169 |
DS34942424
Featured
DS34942424 is an orally potent analgesic without mu opioid receptor agonist activity. |
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DC48170 |
Riminkefon
Riminkefon is a kappa opioid receptor agonist. |
2168572-99-2 |
DC48171 |
Tegileridine
Tegileridine is the potent agonist of opioid receptor (MOR). Tegileridine is an oxa spiro derivative which reduces the side effects mediated by β-arrestin. Tegileridine has the potential for the research of pains and pains-related diseases (extracted from patent WO2017063509A1). |
2095345-66-5 |
DC49057 |
CCG258747
CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, >5500, and >550–fold, respectively).CCG258747 also blocks the internalization of the µ-opioid receptor. G protein-coupled receptor (GPCR) kinases (GRKs) are attractive targets for the research of heart failure. |
2615910-00-2 |
DC49651 |
Acetyl tetrapeptide-15
Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway. |
928007-64-1 |
DC70268 |
BPR1M97
BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively.BPR1M97 elicited full agonist properties for all cell-based assays tested in MOP-expressing cells.BPR1M97 acted as a G protein-biased agonist for NOP.BPR1M97 initiated faster antinociceptive effects after subcutaneous injection and elicited better analgesia in cancer-induced pain than morphine.BPR1M97 caused less respiratory, cardiovascular, and gastrointestinal dysfunction, compared with morphine. |
2059904-66-2 |
DC70726 |
R995045
R995045 is a novel δ-opioid receptor (δOR) agonist with pKi of 5.94, cAMP pIC50 of 6.01, >10-fold selectivity over µOR and κOR.R995045 acts as a negative allosteric modulator for leu-enkephalin potency in the cAMP glosensor assay. |
1285536-79-9 |
DC70882 |
VISTA inhibitor M351-056
VISTA inhibitor M351-056 is a small molecule compound having affinity with VISTA. |
1189495-81-5 |