| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC71982 | ACT-335827 | ACT-335827 is a selective, orally active, brain-penetrant orexin type 1 receptor antagonist. ACT-33582 acts on OXR1 and OXR2 with IC50 values of 6 nM and 417 nM, respectively. ACT-33582 can be used in studies related to neurological disorders. |
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| DC71983 | Nivasorexant Featured | Nivasorexant is a potent orexin receptor antagonist. |
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| DC71984 | Tebideutorexant | Tebideutorexant is a potent orexin receptor antagonist. Tebideutorexant can be used for insomnia research. |
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| DC73480 | (R)-YNT-3708 | (R)-YNT-3708 is a potent, selective orexin 1 receptor (OX1R) agonist with EC50 of 7.48 nM and Emax 101%, 22-fold selectivity over OX2R (IC50=168 nM). |
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| DC73481 | CVN45502 | CVN45502 (CVN 45502) is a potent, orally bioavailable, highly selective orexin 1 receptor (Hcrtr1, OX1R) antagonist with binding affinity (pKi) of 7.86 (human Hcrtr1), significantly reduces feeding and body weight in diet-induced obese (DIO). |
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| DC73482 | CVN766 Featured | CVN766 (CVN 766) is a potent, exquisitely selective orexin 1 receptor (OX1R) antagonist with IC50 of 8 nM, 1000-fold selective over OX2R. |
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| DC73483 | OBPt-9 | OBPt-9 is a potent, postivie allosteric potentiator of orexin receptor-mediated signaling, similarly potentiates the response of OXR1 and OXR2 to orexin A. |
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