DC22038 |
BRD2879 |
BRD2879 (BRD-2879) is a potent, selective inhibitor of IDH1-R132H mutant with IC50 of 50 nM, inhibits cell-based production of R-2HG with EC50 of 0.3 uM. |
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DC20832 |
BRD3308
Featured
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BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms. |
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DC20839 |
BRD3731 |
BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM). |
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DC12426 |
BRD4 inhibitor Compound V |
BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively. |
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DC23880 |
BRD50837 |
BRD50837 is a potent, selective, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 90 nM, partially lowers Gli1 expression at concentrations of 2 uM, a useful probe of Shh signaling pathway. . |
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DC20833 |
BRD5459 |
BRD5459 is a nontoxic enhancer of reactive oxygen species (ROS) that strongly elevates markers of oxidative stress without causing cell death, ROS inducer.. |
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DC20840 |
BRD5529 |
BRD5529 is a small-molecule inhibitor that disrupts the interaction of CARD9-E3 ubiquitin ligase TRIM62 with IC50 of 8.6 uM. |
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DC20834 |
BRD56491 |
BRD56491 is a nontoxic enhancer of reactive oxygen species (ROS) that strongly elevates markers of oxidative stress without causing cell death, ROS inducer.. |
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DC22711 |
BRD5814
Featured
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BRD5814 is a potent, selective, highly brain penetrant β-arrestin biased dopamine D2 receptor (D2R) antagonist with Ki of 0.27 uM. |
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DC23885 |
BRD6851 |
BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist. |
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DC8409 |
BRD7552
Featured
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BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. |
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DC20836 |
BRD9092 |
BRD9092 is a nontoxic enhancer of reactive oxygen species (ROS) that strongly elevates markers of oxidative stress without causing cell death, ROS inducer.. |
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DC23874 |
BRD9526 |
BRD9526 is a potent, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 60 nM, partially lowers Gli1 expression at concentrations of 10 uM, a useful probe of Shh signaling pathway. . |
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DC20837 |
BRD9757 |
BRD9757 is a potent, selective HDAC6 inhibitor with IC50 of 8 nM, displays >20-fold selectivity over HDAC1/3 and other HDAC isoforms.. |
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DC23373 |
BRD9-IN-28 |
BRD9-IN-28 is a highly potent and selective BRD7/9 bromodomain inhibitor with pIC50 of 6.9, Kd of 68 nM for BRD9. |
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DC23356 |
BRD-IN-17 |
BRD-IN-17 is a cell permeable, family VIII bromodomain tool compound with additional PB1(2) activity over and above that of PFI-3. |
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DC23367 |
BRD-IN-26 |
BRD-IN-26 is a potent bromodomain inhibitor that binds the fifth bromodomain of PB1 with a KD of 124 nM, SMARCA2B and SMARCA4 with KD values of 262 and 417 nM, respectively. |
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DC2091 |
Brefeldin A |
Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells. |
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DC20981 |
Brequinar sodium
Featured
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Brequinar sodium (DuP-785, Brequinar, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM. |
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DC8179 |
Briciclib(ON 013105,ON 014185)
Featured
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Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. |
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DC23147 |
Brigatinib (AP-26113)
Featured
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Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM, exhibits about fivefold greater potency in vitro compared with crizotinib. |
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DC4165 |
Brinzolamide |
Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM. |
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DC9535 |
Brivaracetam
Featured
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Brivaracetam(UCB-34714) is a 4-substituted pyrrolidone butanamide as agent with significant antiepileptic activity; high affinity SV2A ligand and also shows an ability to inhibit Na+ channels.
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DC10383 |
Brivudine |
Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster. |
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DC21871 |
BRK inhibitor P21d |
BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM). |
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DC23461 |
BRL 37344 sodium |
BRL 37344 is a potent and selective β3 adrenoceptor agonist with Ki of 287 nM. |
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DC7891 |
BRL 52537 HYDROCHLORIDE |
BRL 52537 is a selective κ/μ opioid receptor agonist. |
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DC20180 |
BRL-50481
Featured
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BRL-50481 is a novel and selective inhibitor of phosphodiesterase (PDE) 7 with a Ki value, derived from secondary (Dixon) plots, of 180±10 nM, being at least 200-fold selective for hrPDE7A1 over all other PDEs. |
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DC9124 |
Bromhexine HCl |
Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. |
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DC22426 |
Bromocriptine |
Bromocriptine (2-Bromoergocriptine. |
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