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Brequinar sodium

  Cat. No.:  DC20981   Featured
Chemical Structure
96201-88-6
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More than 5000 active chemicals with high quality for research!
Field of application
Brequinar sodium (DuP-785, Brequinar, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 96201-88-6
Chemical Name: Brequinar sodium
Synonyms: 4-Quinolinecarboxylicacid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-, sodium salt (1:1);4-Quinolinecarboxylicacid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-, sodium salt (...;Brequinar sodium;sodium,6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylate;Dup 785;Brequinar sodium [USAN];49EEF6HRUS;Brequinar sodium (USAN);Bipenquinate;sodium 6-fluoro-2-{2'-fluoro-[1,1'-biphenyl]-4-yl}-3-methylquinoline-4-carboxylate;sodium 6-fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylate;Brequinar sodium salt;PZOHOALJQOFNTB-UHFFFAOYSA-M;Sodium 6-fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylat;4-Quinolinecarboxylic acid, 6-fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-, sodium salt (9CI);Biphenquinate sodium;NSC 368390;AKOS032962879;Dup-785;sodium 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylate;Bipenquinate Sodium;CCG-221414;AS-74463;sodium 6-fluoro-2-(2'-fluoro[biphenyl]-4-yl)-3-methylquinoline-4-carboxylate;BREQUINAR SODIUM (MART.);MFCD22648381;CHEMBL300058;4-Quinolinecarboxylic acid,6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-, sodium salt;4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-, sodium salt;sodium 6-fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methylquinoline-4-carboxylate;F52273;BREQUINAR SODIUM [WHO-DD];Bipenquinate, BRQ, DUP-785, NSC 368390;DUP785;DTXCID30164664;J-505616;Q27259277;AKOS027326512;Sodium 6-fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylate;NSC-368390;Dihydroorotate Dehydrogenase Inhibitor, Brequinar;C23H14F2NNaO2;BREQUINAR SODIUM [MART.];DB-080412;WDA20188;UNII-49EEF6HRUS;6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt;2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methylquinoline-4-carboxylic acid sodium salt;NSC368390;6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium;BREQUINAR SODIUM SALT [MI];SCHEMBL4265;DuP785 (sodium); NSC 368390 (sodium);sodium 6-fluoro-2-(2'-fluoro(biphenyl)-4-yl)-3-methylquinoline-4-carboxylate;96201-88-6;Brequinar (sodium);s3565;CS-0033939;BREQUINAR SODIUM;AC-35373;Sodium 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methylquinoline-4-carboxylate;sodium;6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylate;HY-108325A;D03154;CHEBI:177871;DTXSID30242173
SMILES: [Na].O=C(C1C(C)=C(C2C=CC(C3C(F)=CC=CC=3)=CC=2)N=C2C=1C=C(C=C2)F)O
Formula: C23H15F2NNaO2
M.Wt: 398.357283830643
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Brequinar sodium (DuP-785, Brequinar, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM; arrests tumor growth in HL60 and MOLM13 subcutaneous xenograft models of AML in NOD SCID mice.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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