| DC26114 |
GpTx-1
Featured
|
GpTx-1 is a potent, selective, 34-residue peptide antagonist of Nav1.7 sodium channel with IC50 of 10 nM, displays 20- and 1000- fold selectivity over NaV1.4 and NaV1.5.. |
|
| DC21064 |
GR-127935 hydrochloride
Featured
|
GR-127935 potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor. |
|
| DC8820 |
GR148672X |
GR148672X is a specific TGH inhibitor. |
|
| DC21065 |
GR-64349 |
GR-64349 is a potent and selective tachykinin NK2 receptor agonist with EC50 of 3.7 nM, displays >1000- and >300-fold selectivity over NK1 and NK3 receptors, respectively.. |
|
| DC21066 |
GR73632
Featured
|
GR-73632 is a potent and selective tachykinin NK1 receptor agonist with EC50 of 2 nM, promotes differentiation but not survival of rat chromaffin cells in vitro.. |
|
| DC9918 |
Gracillin |
Gracillin is a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica with antitumor agent. |
|
| DCAPI1367 |
Grape Seed Extract |
Grape Seed Extract |
|
| DC12095 |
GRGDSP TFA |
GRGDSP (TFA) is an integrin inhibitor. |
|
| DC22629 |
GRL-0617
Featured
|
GRL-0617 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM. |
|
| DC23564 |
GS 462808 |
GS 462808 is a potent Late INa current inhibitor with IC50 of 1.33 uM. |
|
| DC21070 |
GS-1 |
GS-1 is a close structural analog of GS-5806 that acts an RSV fusion inhibitor. |
|
| DC21068 |
GS-493 |
GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay. |
|
| DC12579 |
GS-6207
Featured
|
GS-6207 (GS6207, GS-CA1) is a potent, selective inhibitor of HIV-1 capsid function with potency and potential to be clinically effective against a broad range of HIV-1 strains.. |
|
| DC23381 |
GS-626510 |
GS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT. |
|
| DC7805 |
CID 121433863
Featured
|
GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate. |
|
| DC9294 |
Tenofovir Alafenamide Hemifumarate
Featured
|
GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate. |
|
| DC21071 |
GS-9451 |
GS-9451 (Vedroprevir) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays. |
|
| DC7138 |
GS-9620(Vesatolimod)
Featured
|
GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7(TLR-7) in chimpanzees with chronic HBV infection. |
|
| DC23244 |
GS-9695 |
GS-9695 is a potent, non-catalytic site HIV integrase inhibitor with wild type EC50 of 1.2 nM.. |
|
| DC7626 |
GS9973（Entospletinib）
Featured
|
GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. Phase 2. |
|
| DC23876 |
GSA-10
Featured
|
GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay. |
|
| DC7654 |
GSK J4 HCl
Featured
|
GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family. |
|
| DC7042 |
GSK-126
Featured
|
GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase with Ki value of 0.5 nM. |
|
| DC9714 |
SCD inhibitor GSK1940029
Featured
|
GSK1940029 is a stearoyl CoA desaturase 1 inhibitor. |
|
| DC20282 |
GSK199
Featured
|
GSK199 is a reversible inhibitor of PAD4 (IC50 = 200 nM) that binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3. |
|
| DC10912 |
GSK-2200150A
Featured
|
GSK2200150A is an antimycobacterial agent against Mycobacterium tuberculosis and Mycobacterium bovis BCG. |
|
| DC7650 |
GSK2334470
Featured
|
GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases. |
|
| DC8520 |
GSK-25
Featured
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
|
| DC6315 |
GSK2636771
Featured
|
GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines. Phase 1/2a. |
|
| DC5029 |
PERK inhibitor GSK2656157
Featured
|
GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC50 of 0.9 nM. It is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases. |
|
