| DC21568 |
GMI-1070 |
GMI-1070 (Rivipansel, PF-06460031) is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively. |
|
| DC12343 |
GNE 220 Hydrochloride |
GNE 220 (Hydrochloride) is a potent and selective inhibitor of MAP4K4, with an IC50 of 7 nM. |
|
| DC23124 |
GNE-0439 |
GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM). |
|
| DC22532 |
GNE-049 |
GNE-049 (GNE049) is a potent, selective, orally available inhibitor of CBP/p300 bromodomain with biochemical IC50 of 1.1/2.3 nM, respectively. |
|
| DC23805 |
GNE-220 |
GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM. |
|
| DC23337 |
GNE-2861 |
GNE-2861 is a potent, selective group II PAK (PAK4/5/6) inhibitor with IC50 of 7.5/126/36 nM, respectively, shows selectivity over group I PAKs (IC50=5.42/0.97/>10 uM for PAK1/2/3). |
|
| DC21057 |
GNE-293 |
GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively. |
|
| DC23374 |
GNE-375 |
GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1. |
|
| DC23869 |
GNE-431 |
GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM and 2.5 nM for WT Btk and C481S mutant, respectively. |
|
| DC26078 |
GNE-616
Featured
|
GNE-616 (GNE616) is a highly potent, metabolically stable, subtype selective inhibitor of Nav1.7 with Ki of 0.79 nM (hNav1.7). |
|
| DC10096 |
GNE-617
Featured
|
GNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. |
|
| DC23165 |
GNE-7915 tosylate |
GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM. |
|
| DC26024 |
GNE-8324
Featured
|
GNE-8324 is a potent and selective NMDA receptor PAM. |
|
| DC23350 |
GNE-886 |
GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM. |
|
| DC20074 |
GNE-955 |
GNE-955 is a potent pan Pim kinase inhibitor with Kis of 18, 110, 8 nM for Pim1, Pim2, Pim3, respectively. |
|
| DC7420 |
GNF-5
Featured
|
GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22±0.1 uM (Wild type Abl). |
|
| DC7136 |
GNF-5837
Featured
|
GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). |
|
| DC20204 |
GNF-6231 |
GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM. |
|
| DC21060 |
GNX-865 |
GNX-865 is a potent mitochondrial permeability transition pore (mPTP) inhibitor with EC50 of 105 uM (mitochondrial swelling). |
|
| DC22100 |
GO289
Featured
|
GO289 (GO-289, GO 289) is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM in in vitro kinase assays, shows minor effects on CKIδ and CKIα activity in vitro. |
|
| DC20393 |
Golgicide A
Featured
|
Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM. |
|
| DC26017 |
Golotimod (SCV-07)
Featured
|
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. |
|
| DC23028 |
Gomisin A
Featured
|
Gomisin A has anti-inflammatory, antihypertensive, neuroprotective, and anti-proliferation properties, it induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal tran |
|
| DC12542 |
GOT1 inhibitor 2c
Featured
|
GOT1 inhibitor 2c is a first-in-class, non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with IC50 of 8.2 uM.. |
|
| DC9375 |
GPDA
Featured
|
GPDA(Glycylproline p-nitroanilide tosylate) is the substarate of X-Prolyl dipeptidyl-aminopeptidase in the enzyme assay. |
|
| DC21902 |
GPR139 agonist AC4 |
GPR139 agonist AC4 is a novel small molecule GPR139 receptor agonist with EC50 of 220 nM in calcium mobilization assay in CHO-GPR139 cells. . |
|
| DC20394 |
GPR39 modulator 3 |
GPR39 modulator 3 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=5 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels. |
|
| DC20395 |
GPR39 modulator 7 |
GPR39 modulator 7 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=20 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels. |
|
| DC20076 |
GPR4 antagonist 3(NE 52-QQ57 )
Featured
|
GPR4 antagonist 3 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. Anti-inflammatory activities. |
|
| DC22224 |
Gpr52 antagonist E7 |
Gpr52 antagonist E7 (Scabertopin) is a novel Gpr52-specific small molecule antagonist, reduces mutant HTT levels and rescues Huntington's disease-associated phenotypes in cellular and mouse models.. |
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