DC7853 |
GSK2801
Featured
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GSK2801 is a very potent inhibitor of the BAZ2 family of bromodomain containing proteins. |
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DC9719 |
Lp-PLA2 -IN-1(GSK2814338)
Featured
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GSK2814338, also known as Lp-PLA2 -IN-1, is a Lp-PLA2 inhibitor |
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DC7847 |
HIV Inhibitor GSK2838232
Featured
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GSK2838232 is a novel human immune virus (HIV) maturation inhibitor being developed for the treatment of chronic HIV infection. |
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DC22317 |
GSK-2894631A(HPGDS inhibitor 2)
Featured
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GSK-2894631A,GSK 2894631A,GSK2894631A |
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DC9717 |
amyloid P-IN-1(GSK3039294)
Featured
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GSK3039294 is a Serum amyloid P component inhibitor. |
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DC26011 |
GSK3145095
Featured
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GSK3145095 is an orally available, small-molecule inhibitor of RIPK1, with potential antineoplastic and immunomodulatory activities. |
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DC8505 |
GSK369796
Featured
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GSK369796 shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 strain |
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DC22306 |
cGAS inhibitor 467
Featured
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GSK467 is a potent and selective inhibitor of KDM5 (also known as JARID1). GSK467 exploits unique binding modes. |
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DC12513 |
RIP1 inhibitor GSK547
Featured
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GSK547 (RIP1i, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo. |
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DC8373 |
GSK8573
Featured
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GSK-8573 is the inactive control of GSK-2801. |
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DC26130 |
GSK8612
Featured
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GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. |
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DC9907 |
GSK9311
Featured
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GSK9311 is a potent and highly selective inhibitor of the BRPF bromodomain (BRPDF1 pIC50 = 6.0; BRPDF2 pIC50 = 4.3). |
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DC10064 |
GSK-F1
Featured
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GSK-F1 is a potent inhibitor of PI4KA. |
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DC7858 |
GSK-J1
Featured
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GSK-J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM for human JMJD3 in vitro). |
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DC7857 |
GSK-LSD1
Featured
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GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). |
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DC23890 |
GSM-1 |
GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay. |
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DC23886 |
GSM-2 |
GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels. |
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DC20399 |
GSTO1 inhibitor C1-27 |
GSTO1 inhibitor C1-27 is a potent, selective, covalent glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 31 nM. |
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DC20112 |
GT 949
Featured
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GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM. |
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DC21403 |
GTC 365 |
GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters. |
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DC21404 |
GTC 365 hydrochloride |
GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters. |
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DCAPI1387 |
Guaifenesin(Guaiphenesin) |
Guaifenesin(Guaiphenesin) |
|
DC21825 |
Guanabenz
Featured
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Guanabenz (WY 8678) is an α2 adrenergic receptor agonist that is used as an antihypertensive agent, also has been proposed to exert protective effects against misfolding by interfering with eIF2α-P dephosphorylation through selective disruption of a PP1-P |
|
DC12076 |
Guanidinosuccinic acid |
Guanidinosuccinic acid is a nitrogenous metabolite isolated in excess from serum and urine. |
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DC23297 |
GUT-70 |
GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis. |
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DC23117 |
GV-58 |
GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM, shows no acitivity for L-type calcium channels (EC50>100 uM). |
|
DC21102 |
GW 275175X |
GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation. |
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DC23402 |
GW 841819X |
GW 841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomain that displays activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia.. |
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DC23142 |
GW274150
Featured
|
GW274150 is a novel arginine-competitive, NADPH-dependent iNOS inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS (> 260-fold) and nNOS (> 219-fold) and high bioavailability (> 90%) after oral administration.Target: iNOSin vivo: GW274150 demonstrates a narrow neuroprotective therapeutic window against the toxic actions of 6-OHDA. GW274150 administration leads to a dose-dependent decrease in the number of iNOS-positive cells in the SNc of the 6-OHDA-lesioned animals. The iNOS inhibitor GW274150 fails to produce long-term neuroprotection after its withdrawal in the 6-OHDA-lesioned rat. [1] |
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DC8193 |
GW311616A |
GW311616A is a potent, intracellular human neutrophil elastase (HNE, α-1-proteinase) inhibitor. |
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