Home > Inhibitors & Agonists > Others > Other Targets
Cat. No. Product name CAS No.
DC7748 AZD-26(AKT-IN-1) Featured

AZD-26 is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC50 of 422 nM.

1357158-81-6
DC6302 AZD2858 Featured

AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.

486424-20-8
DC20050 AZD2906

AZD2906 is a selective glucocorticoid receptor (GR) agonist, with IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively. AZD2906 increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats

1034148-15-6
DC20724 AZD-3161

AZD-3161 is a potent and selective sodium channel Nav1.7 blocker for treatment of nociceptive pain. .

1369501-46-1
DC20129 AZD3229 Featured

AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

2248003-60-1
DC12265 AZD3229 Tosylate

AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

2248003-71-4
DC7074 AZD-3463 Featured

AZD-3463 is an ALK/IGF1R inhibitor which overcomes multiple mechanisms of acquired resistance to crizotinib.

1356962-20-3
DC20725 AZD 4017

AZD4017 is a potent, selective, and orally bioavailable human 11β-HSD1 with IC50 of 7 nM, shows no significant activity against 11β-HSD1 and 17β-HSD1, 17β-HSD3 (IC50>30 uM).

1024033-43-9
DC23282 AZD 4320

AZD4320 is a BH3 mimetic and dual Bcl-2/Bcl-XL inhibitor with IC50 of <1 nM.

1357576-48-7
DC23436 AZD-4818

AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.

1003566-93-5
DC20727 AZD-5248

AZD-5248 is a potent, selective, first generation, oral inhibitor of dipeptidyl peptidase 1 (DPP1)..

1254318-44-9
DC7368 AZD5363 Featured

AZD5363, a novel pyrrolopyrimidine-derived compound, inhibits all AKT isoforms (IC50 <10 nM).

1143532-39-1
DC20716 AZD5576

AZD5576(AZD 5576) is a potent, highly selective, and orally bioavailable inhibitor of CDK9 with IC50 of < 5 nM, decreases phosphorylation of Ser2-RNAPII in cells with an IC50 of 96 nM.

DC22009 AZD5718 Featured

AZD5718 (AZD-5718, AZD 5718) is a novel potent 5-lipoxygenase activating protein (FLAP) inhibitor with binding IC50 of 6.3 nM; exhibits LTB4 inhibition in human whole blood assays with IC50 of 39 nM; reduce the production of pro-inflammatory and vasoactive leukotrienes both in vitro and in vivo.

2041075-86-7
DC20728 AZD-5718

AZD-5718 is an orally available small molecule, 5-lipoxygenase activating protein (FLAP) inhibitor..

DC22007 AZD5904

AZD5904 (AZD-5904) is a potent, selective irreversible, orally bioavailable myeloperoxidase (MPO) inhibitor with IC50 of 140 nM, similar potency in mouse and rat.

618913-30-7
DC12553 AZD6088

AZD6088 (AZD-6088) is a potent and selective, orally bioavailable partial agonist of the M1 muscarinic receptor, reduces heat hyperalgesia in SNL rats with an EC50 of 46.6 nM..

1131451-40-5
DC20731 AZD-7325 Featured

AZD-7325 is a potent, α2/3 functionally selective, partial GABAA receptor modulator with pKi of 9.51.

942437-37-8
DC8837 AZD-7547 Featured

AZD7545 is a novel, selective small-molecule inhibitor of PDHK2 (PDH kinase2) with an IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2 respectively.

252017-04-2
DC20714 AZD-7594 Featured

AZD-7594 (AZ-13189620) is a potent, nonsteroidal, selective glucocorticoid receptor modulator (SGRM) with binding IC50 of 0.9 nM, shows no affinity for AR, PR, MR and ERα/β.

1196509-60-0
DC20242 AZD-7624 Featured

AZD-7624 a potent, selective, inhaled p38α MAPK inhibitor for the treatment of chronic obstructive pulmonary disease.

1095004-78-6
DC20278 AZD-7648 Featured

AZD-7648 is a potent and selective DNA-PK inhibitor. Anti-tumour activity.

2230820-11-6
DC20733 AZD-8165

AZD-8165 is a potent, selective and oral thrombin inhibitor for treatment of thrombosis..

1201686-72-7
DC20734 AZD-8309

AZD-8309 (AZD8309) is a potent and orally bioavailable CXCR2 antagonist that has been proposed to regulate the transmigration of neutrophils.

333742-48-6
DC20735 AZD 8329

AZD8329 is a potent, selective 11β-HSD1 inhibitor with IC50 of 9 nM, displays excellent selectivity versus relatedd 11β-HSD2, 17β-HSD1 and 17β-HSD3 (IC50>30 uM).

1048668-70-7
DC23437 AZD-8529 Featured

AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes.

1092453-15-0
DC23408 AZD-8529 mesylate Featured

AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes.

1314217-69-0
DC10202 AZD8797 Featured

AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor; antagonizes CX3CL1 with IC50 values of 6 and 300 nM in B-lymphocyte cell line and human whole blood, respectively.

911715-90-7
DC20737 AZD-9819

AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease..

956907-23-6
DC10245 Azelaic acid

Azelaic acid is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.

123-99-9
DC8338 Azeliragon(PF-04494700,TTP488) Featured

Azeliragon is an oral, small-molecule inhibitor of RAGE.

603148-36-3
DCAPI1590 Azelnidipine

Azelnidipine is an L-type calcium channel protein inhibitor

123524-52-7
DC20156 Azetidine-2-carboxylic acid Featured

Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent.

36476-78-5
DC4141 Azocosterol 2HCL

Azocosterol is a potential avian reproductive inhibitor.

1249-84-9
DCAPI1225 Azomycin (2-Nitroimidazole)

Azomycin (2-Nitroimidazole)

527-73-1
DC9818 Azoramide Featured

Azoramide is a small-molecule modulator of the unfolded protein response with antidiabetic activity.

932986-18-0
DC12497 (Z)-Azoxystrobin Featured

Azoxystrobin is a systemic, broad-spectrum fungicide belonging to the class of methoxyacrylates,which are derived from the naturally-occurring strobilurins.

143130-94-3
DC22953 AZSMO-23

AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively.

496793-75-0
DCAPI1341 Aztreonam (Azactam, Cayston)

Aztreonam (Azactam, Cayston)

78110-38-0
DC21570 Azvudine Featured

Azvudine (RO 0622) is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 24 nM; inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations (IC50=10-100 nM).

1011529-10-4
DC23756 Aβ polymerization stimulator O4

Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ).

71939-12-3
DC12114 B I09

B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.

1607803-67-7
DC22010 B591

B591 (B-591) is a potent, specific pan-PI3K inhibitor with IC50 of 1.3/0.36/1.1/1.58 uM for PI3Kα/β/γ/δ, respectively.

1498412-41-1
DC22011 BAA473

BAA473 (BAA-473) is a bile acid analogue that functions as the first small molecule activator of the Pyrin inflammasome, induces secretion of IL18 in LPS-primed PBMCs.

20231-68-9
DC10859 Baccatin III Featured

Baccatin III is the precursor to paclitaxel/ taxol. Antileukaemic and antitumor agent isolated from the bark of the Pacific yew tree (Taxus breviofolia).

27548-93-2
DC20063 BACE1-IN-2

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM.

1352416-78-4
DCAPI1066 Bacitracin zinc

Bacitracin zinc

1405-89-6
DC8858 Bafilomycin A1(Baf-A1) Featured

Bafilomycin A1 is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM.

88899-55-2
DC20740 BAL30072

BAL30072 is a monocyclic beta-lactam antibiotic that shows potent activity against MDR Pseudomonas aeruginosa and Acinetobacter sp. Isolates with MIC90 of 8 and 4 ug/ml.

941285-15-0
DCAPI1046 Balofloxacin

Balofloxacin

127294-70-6
DC9562 Balsalazide

Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.

80573-04-2
DC10502 BAPTA/AM(BAPTA-AM) Featured

BAPTA/AM is a membrane permeable form of BAPTA, a selective chelator of Ca2+.

126150-97-8
DC10564 BAR 502 Featured

BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.

1612191-86-2
DC20317 Barbadin

Barbadin is a small molecule that selectively inhibits the β-arrestin/β2-adaptin interaction (IC50=19.1/15.6 uM for β-arrestin1/2) without effect on the formation of receptor/β-arrestin complexes.

356568-70-2
DC12663 Bax channel blocker(BAI-1) Featured

Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity.

335165-68-9
DC23719 BAY 1024767

BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD).

1273068-71-5
DC20750 BAY 1143269

BAY 1143269 is a potent, selective, orally bioavailable inhibitor of MNK1 with enzyme IC50 of 40 nM at 2 mM ATP.

DC23386 BAY 1238097

BAY 1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM, inhibits the interaction between BRD4, BRD3 or BRD2 and H4 with IC50 values of 63 nM, 609 nM and 2430 nM in the NanoBRET assay.

1564268-08-1
DC20589 BAY 1251152 Featured

BAY 1251152 (VIP152 ) is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM, displays> 50-fold selectivity against other CDKs.

1610358-56-9
DC23745 BAY-2402234 Featured

BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM (human full-length DHODH).

2225819-06-5
DC10291 Bay 41-4109 less active enantiomer

Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.

476617-51-3
DC20747 BAY 41-8543

BAY 41-8543 is an NO-independent sGC (soluble guanylyl cyclase) stimulator, inhibits collagen-mediated aggregation in washed human platelets (IC50=90 nM).

256498-66-5
DC7323 Pritelivir(BAY-57-1293) Featured

BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex.

348086-71-5
DC4113 Cinaciguat (BAY 58-2667) Featured

BAY 58-2667 is a nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator. Displays potent cardiovascular effects.

329773-35-5
DC20748 BAY 60-2770

BAY 60-2770 is an NO-independent activator of sGC (soluble guanylyl cyclase) with EC50 of 5.4 nM.

1027642-43-8
DC23438 BAY 60-6583

BAY 60-6583 (BAY606583) is a potent, selective adenosine A2B receptor agonist with EC50 of 2.83 nM (murine A2BR).

910487-58-0
DC26066 BAY 61-3606 hydrochloride Featured

BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.

1615197-10-8
DC9591 BAY 80-6946(Copanlisib) Featured

BAY 80-6946(Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM.

1032568-63-0
DC7996 BAY 87-2243 Featured

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation.

1227158-85-1
DC23559 Bay K-8644 Featured

Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo.

71145-03-4
DC22013 BAY-1316957 Featured

BAY-1316957 (BAY 1316957) is a highly potent, selective, orally available human prostaglandin E2 receptor subtype 4 (hEP4-R) antagonist with IC50 of 15.3 nM.

1613264-40-6
DC20751 BAY-1816032 Featured

BAY-1816032 (BAY1816032) is a highly potent, selective, orally active BUB1 mitotic checkpoint serine/threonine kinase with IC50 of 7 nM, displays excellent selectivity on a panel of 395 kinases.

1891087-61-8
DC26020 BAY2335218(BAY-218) Featured

BAY2335218(BAY-218) is the first-in-class AhR antagonist for overcoming tumor-mediated immunosuppression.

2162982-11-6
DC23816 BAY-293 racemate

BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM)..

2244904-14-9
DC11006 BAY-320

BAY-320 (BAY320) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 680 nM.

1445830-50-1
DC22015 BAY-386

BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM).

1256941-06-6
DC11007 BAY-524

BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.

1445830-39-6
DC26010 BAY-545 Featured

BAY-545 is a novel, potent and selective antagonist of A2B adenosine receptor with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2Badenosine receptor in cells, respectively.

1699717-32-2
DC12653 BAY-598 Featured

BAY-598 is a selective inhibitor of SMYD2.

1906919-67-2
DC12088 BAY-678 racemate

BAY-678 racemate is a chemical probe candidate for Human Neutrophil Elastase (HNE).

675103-35-2
DC20749 BAY-707

BAY-707 is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM.

2109805-96-9
DC22016 BAY-7598

BAY-7598 (BAY7598) is a potent, selective MMP12 inhibitor..

1816257-74-5
DC22017 BAY-826

BAY-826 (BAY826) is a novel selective, highly potent, orally available TIE-2 inhibitor (dissociation constant=1.6 nM).

1448316-08-2
DC10057 Bayer-18 Featured

Bayer-18 is a selective TYK2 inhibitor, with an IC50 of 18.7nM on TYK2 as measured by TYK2 HTRF assays.

1251752-12-1
DC12280 BB-Cl-Amidine

BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor.

1802637-39-3
DC20754 BC-1215 Featured

BC-1215 (BC1215) is a highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL.

1507370-20-8
DC20755 BC-1485

BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.

2035085-19-7
DC21401 BC-21

BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM.

691005-38-6
DC20757 BC-23

BC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM.

6298-15-3
DC20758 BCI-137

BCI-137 is a chemical compound able to compete with Argonaute 2 miRNAs binding, binds to Ago2 with Kd of 126 uM.

112170-24-8
DC12446 BCL6 inhibitor 14

BCL6 inhibitor 14 is a potent BCL-6 inhibitor with FRET IC50 of 63 nM..

DC12447 BCL6 PROTAC 15

BCL6 PROTAC 15 is a novel B-cell lymphoma 6 (BCL6) PROTAC, significantly degrade BCL6 in a number of DLBCL cell lines, but neither BCL6 inhibition nor degradation selectively induces marked phenotypic response.

DC20760 BCL6-IN-8

BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface.

2204272-40-0
DC20761 BCM-599

BCM-599 is an efficient HBV capsid assembly inhibitor with in vitro IC50 of 13 uM, shows synergistic inhibitory effects on decreasing viral concentration combined with lamivudine in vivo..

1820763-99-2
DC23980 BCX-1470

BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).

217099-43-9
DC23499 BD-1047 Featured

BD-1047 is a potent, selecitve Sigma 1 receptor (σ1) antagonist with Ki of 0.93 nM.

138356-20-4
DC21101 BDCRB Featured

BDCRB (GW 275175) is a potent and selective inhibitor of human CMV replication by blocking the processing and maturation of viral DNA..

142356-43-2
DC20763 BDP8900

BDP8900 (BDP-8900) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM (MRCKβ), >100-fold selectivity over related ROCK1 or ROCK2.

2226507-05-5
DC20764 BDP9066

BDP9066 (BDP-9066) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM, >100-fold selectivity over related ROCK1 or ROCK2.

2226507-04-4
DC12596 BDP-NAC

BDP-NAC is a novel persulfide donor that shows selectivity towards H2 O2 over other potential oxidative or nucleophilic triggers, resulting in the sustained release of the persulfide of N-acetyl cysteine (NAC).

2230306-52-0
DC20765 BDT001 Featured

BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM.

823837-22-5
DC20319 Beauvericin

Beauvericin is a cyclic hexadepsipeptide with antibiotic and insecticidal effects, shows activity against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals..

26048-05-5
DC20668 Becampanel

Becampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM.

188696-80-2
DC9172 Beclomethasone Dipropionate

Beclometasone dipropionate is a potent glucocorticoid agonist; it is a prodrug of the free form, beclometasone.

5534-09-8
DC21007 Befiradol Featured

Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM.

208110-64-9
DC20030 Begacestat (GSI-953)

Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease.

769169-27-9
DC20135 Bemesetron (MDL 72222)

Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effect.

40796-97-2
DC6908 Bendamustine HCL (SDX-105, Cytostasane) Featured

Bendamustine HCL (Ribomustin, Treanda, SDX-105) is a DNA-damaging agent with IC50 of 50 μM.

3543-75-7
DC12299 Benfluralin

Benfluralin is a kind of herbicide and an agrochemical which can be used as a pre-emergence herbicide used for the control of grass and other weeds in a range of food and non-food crops.

1861-40-1
DCAPI1606 Benserazide

Benserazide is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.

14919-77-8
DC10701 Benzamide (NSC 404988) Featured

Benzamide (NSC 404988) is a bioactive compound.

7461-38-3
DC20185 Benzamidine HCl

Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively.

1670-14-0
DC26053 Benzamil (hydrochloride) Featured

Benzamil hydrochloride is a specific and potent sodium channel (ENaC) blocker.

161804-20-2
DC22184 Benzarone

Benzarone (NSC 82134) is a small molecule inhibitor of Eyes Absen (EYA) protein tyrosine phosphatase activity (IC50=17 uM, EYA3), exhibits selectivity for EYA over PTP1B.

1477-19-6
DC9885 Benzenesulfonamide

Benzenesulfonamide ia an inhibitor of carbonic anhydrases

98-10-2
DC20028 Benznidazole (Synonyms: Benznidazol; Ro 07-1051; Ro 71051) Featured

Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease.

22994-85-0
DC10223 Benzocaine hydrochloride

Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

23239-88-5
DC12173 Benzyl alcohol (Benzenemethanol)

Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor.

100-51-6
DC20216 Benzylcetyldimethylammonium chloride hydrate

Benzylcetyldimethylammonium chloride hydrate is a chemical.

122-18-9
DC22482 Bephenium hydroxynaphthoate

Bephenium hydroxynaphthoate is an anthelmintic compound that acts as an activiator of nematode B-type nAChR, is used in the treatment of hookworm infections and ascariasis..

3818-50-6
DC22478 Bephenium

Bephenium is an anthelmintic compound that acts as an activiator of nematode B-type nAChR, is used in the treatment of hookworm infections and ascariasis..

7181-73-9
DC11403 Bepridil hydrochloride Featured

Bepridil hydrochloride is a calcium channel blocker, with antianginal activity.

68099-86-5
DC21868 Berotralstat

Berotralstat is a potent human plasma kallikrein inhibitor.

1809010-50-1
DC21519 Besifovir

Besifovir (PMCDG Dipivoxil, NA-380, LB-80380) is a potent, selective, orally available anti-HBV agent, the prodrug of PMCDG (EC50=4 uM)..

441785-26-8
DC21382 EIDD-1931(NHC) Featured

EIDD-1931 (β-d-N4-Hydroxycytidine, NHC) inhibits both murine hepatitis virus (MHV) (EC50 of 0.17 μM) and Middle East respiratory syndrome CoV (MERS-CoV) (EC50 of 0.56 μM) with minimal cytotoxicity. It also inhibits SARS-CoV-2 and multiple 2 endemic, epide

3258-02-4
DC10655 3-Guanidinopropionic acid Featured

Beta-guanidinopropionic acid is a novel creatine kinase inhibitor.

353-09-3
DCAPI1169 Betamethasone (Celestone)

Betamethasone (Celestone)

378-44-9
DC12320 Betanin

Betanin has potent antioxidant and anti-inflammatory effect, that could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM. Betanin is a red glycoside obtained from beets that can be used as colorant.

7659-95-2
DCAPI1040 Betapar(Meprednisone)

Betapar(Meprednisone)

1247-42-3
DC11483 Betrixaban maleate Featured

Betrixaban (PRT-054021) is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a).

936539-80-9
DC23068 Liquidambaric acid Featured

Betulonic acid has anti-cancer , anti-HIV,hepatoprotective and anti-inflammatory activities, it has antiviral activity against herpes simplex virus, it also suppresses ECHO 6 virus reproduction.

4481-62-3
DC9643 Bevirimat(PA-457) Featured

Bevirimat(YK FH312; FH11327; MPC-4326) is an anti-HIV drug derived from a betulinic acid-like compound; is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition.

174022-42-5
DCAPI1078 Bexarotene

Bexarotene

153559-49-0
DC8786 NVP-BEZ235 Tosylate Featured

BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.

1028385-32-1
DC12131 BF-227(E/Z) Featured

BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils.

845647-80-5
DC20797 BF 844

BF 844 (BioFocus 844) is a small molecules capable of stabilizing mutant USH3 mutation CLRN1(N48K).

1404506-35-9
DC12136 BF-168

BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42.

634911-47-0
DC20767 BF738735

BF738735 is a novel, broad-spectrum inhibitor of enterovirus replication (EC50=4-71 nM) that specifically targets host cell factor PI4KIIIβ with IC50 of 5.7 nM, 300-fold less potent for PI4KIIIα (IC50=1.7 uM).

1436383-95-7
DC22196 BGC20-1531

BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.

1962928-26-2
DC10059 BGG463 Featured

BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.

890129-26-7
DC21359 BHC

BHC (Myosin inhibitor BHC) is a small-molecule screen of skeletal muscle myosin inhibitor that suppresses movements without affecting membrane currents.

342387-19-3
DC23177 BHPI

BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells.

56632-39-4
DC21546 BI-1467335 HCl Featured

BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.

1478364-68-9
DC22021 BI 167107 Featured

BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).

1202235-68-4
DC20776 BI 187004

BI 187004 (VTP-34072) is a novel potent, selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor intended to treat type 2 diabetes mellitus (T2D)..

1303515-32-3
DC20778 BI 207524

BI 207524 is a potent inhibitor of HCV thumb pocket 1 NS5B inhibitor with IC50 of 84 nM, inhibits Gt 1a/1b replicons with EC50 of 29/11 nM..

874675-53-3
DC22026 BI 665915

BI 665915 is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 1.7 nM.

1360550-04-4
DC20781 BI 671800 Featured

BI 671800 is a potent, oral prostaglandin D2 receptor (CRTH2) antagonist for treatment of asthma..

1093108-50-9
DC23527 BI 6901

BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0, shows high selectivity over other GPCRs.

2040401-92-9
DC23347 BI 7189

BI 7189 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9, displays >1,000 fold selectivity over the bromodomains of BRD4.

1883429-32-0
DC23391 BI 7271

BI 7271 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9.

1883429-34-2
DC20783 BI 831266

BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.

958227-46-8
DC23348 BI 894999

BI 894999 is a novel potent, selective BET inhibitor with IC50 of 5 and 41 nM for BRD4-BD1 and BRD4-BD2 bromodomains, respectively.

1660117-38-3
DC23560 BI01383298 Featured

BI01383298 (BI-01383298) is a potent, specific sodium-citrate co-transporter SLC13A5 (NaCT, INDY), highly selective over other family members and other transporters..

2227549-00-8
DC12406 BI-0314 Featured

BI-0314 (BI0314) is an allosteric activator of protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) with potency of 56% at 500 uM, displays no activity against hPTP1B and hTCPTP.

2244560-46-9
DC23049 BI1002494

BI1002494 (BI-1002494) is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin).

1319738-39-0
DC20775 BI-1347 Featured

BI-1347 is a potent, selective inhibitor of CDK8/cyclinC with IC50 of 1 nM.

2163056-91-3
DC22020 BI-1388

BI-1388 is a potent, specific, macrocyclic inhibitor of HCV NS3 protease, inhibits viral replication for various HCV genotypes and for resistant mutants D168V and R155K.

1309952-03-1
DC20777 BI-1935

BI-1935 is a potent, selective small molecule inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 7 nM.

940954-41-6
DC22022 BI-1950

BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM.

1159724-42-1
DC22023 BI-3663

BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines.

DC20779 BI-3802 Featured

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.

2166387-65-9
DC23310 BI-3812 Featured

BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity.

2166387-64-8
DC22024 BI-4394

BI-4394 is a highly potent, selective MMP-13 inhibitor with IC50 of 1 nM, displays >1,000 fold selectivity against nine other MMP isoforms (MMP2/14, IC50=18/8.3 uM).

1222173-37-6
DC22310 BI-4464 Featured

BI-4464 (BI 4464) is a potent, highly selective, ATP competitive inhibitor of Focal adhesion tyrosine kinase (PTK2/FAK) with IC50 of 17 nM..

1227948-02-8
DC20784 BI8622

BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b).

1875036-74-0
DC20785 BI8626

BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM).

1875036-75-1
DC23608 BI-9627

BI-9627 is a potent, selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) with pHi change IC50 of 6 nM, displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform.

1204329-34-9
DC12567 BI-9667

BI-9667 (BI9667) is a potent, selective CCR1 antagonist..

1295298-26-8
DC22027 BI-99179

BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM.

1291779-76-4
DC4206 Biapenem

Biapenem is a carbapenem antibiotic.

120410-24-4
DC23366 biBET

biBET is a potent, selective, bivalent inhibitor of BET bromodomains with pKd of 8.3/7.3/11 for BRD4(1)/BRD4(2)/BRD4(1,2), respectively.

2059110-46-0
DC20788 BIBO-3304 Featured

BIBO 3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively.

191868-14-1
DC12211 BIBR 1087 SE (Desethyl Dabigatran Etexilate)

BIBR 1087 SE is an intermediate metabolite of dabigatran etexilate.

212321-78-3
DC20789 BIBU1361

BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).

793726-84-8
DC20790 BIBU1361 dihydrochloride

BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).

1643609-75-9
DC1024 Afatinib (BIBW2992) Featured

BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.

439081-18-2
DC20791 BIIL260

BIIL260 is the active metabolite of BIIL284, shows high affinity to LTB4 receptor on isolated human neutrophil cell membranes with Ki of 1.7 nM.

204974-93-6
DC20793 BILH-434

BILH-434 is a potent HPV11 E1/E2/DNA complex inhibitor that binds to the transactivation domain (TAD) of E2 protein with a Kd of 40 nM, has an IC50 of 180 nM in the E1-E2-ori complex formation assay..

760169-28-6
DC22281 Bilobalide Featured

Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba.

33570-04-6
DC6801 Bindarit Featured

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

130641-38-2
DC20795 BIO 8898

BIO 8898 is a synthetic, CD40-CD154 co-stimulatory interaction inhibitor that inhibits the TNF family cytokine CD40L binding to CD40-Ig with a potency of IC50=25 uM.

402564-79-8
DC11069 BIO124

BIO124 (BIO-124) is a modest inhibitor of the PICK1-GluA2 interaction with IC50 of 0.51 uM in FP assays, binds to the PDZ domain of PICK1..

DC12401 BIO922

BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors.

DC8368 BIO-acetoxime Featured

BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO

667463-85-6
DC20320 Bio-AMS

Bio-AMS is a chemical inhibitor of Mycobacterium tuberculosis biotin protein ligase ( MtBPL) with Kd of 0.865 nM.

1393881-52-1
DC23078 Biperiden Featured

Biperiden (KL 373) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker..

514-65-8
DC25079 Biperiden hydrochloride Featured

Biperiden Hcl (NSC 170950, NSC 84989) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker..

1235-82-1
DC5023 Birinapant (TL32711) Featured

Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP.

1260251-31-7
DC10863 Bis(tributylammonium) difluoromethylenediphosphonate Featured

Bis(tributylammonium) difluoromethylenediphosphonate

81336-71-2
DC10504 BISF-3 Featured

BISF CAS 118511-97-0

118511-97-0
DC20798 Bisperoxovanadium

Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=3

171202-16-7
DC20212 Bisphenol A

Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking, hormone-like properties.

80-05-7
DC21599 Bis-T-23

Bis-T-23 is a small molecule that stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity, increases actin polymerization in injured podocytes.

171674-76-3
DC11307 Bitertanol

Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, including V. inaequalis and V. pirina.

55179-31-2
DC9616 BIX 02565 Featured

BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1 nM.

1311367-27-7
DC23383 Bizine

Bizine is a phenelzine analog that inhibits LSD1 with Ki of 59 nM, displays 23-fold, 63-fold, and >100-fold selectivity for LSD-1 over MAOA, MAOB, and LSD2 respectively.

1591932-50-1
DC20739 BJE6-106

BJE6-106 (B106) is a potent, selective PKCδ inhibitor with IC50 of 50 nM, displays excellent selectivity over classical PKC isozymes (a 1,000-fold PKCδ selectivity over PKCα).

1564249-38-2
DC22637 BKI1369 Featured

BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves.

1951431-22-3
DC23439 BL-1020

BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist.

503537-33-5
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