Cat. No. | Product name | CAS No. |
DC20800 |
BL-918
Featured
BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM), induces autophagy via the ULK complex in SH-SY5Y cells. |
2101517-69-3 |
DC12391 |
BL-AD008
Featured
BL-AD008 (BL-AD 008) is a novel small molecule, dual-target activator targeting AMPK/ZIPK; demonstrates remarkable anti-proliferative activities toward cervical cancer cells and could induce apoptosis by death-receptor and mitochondrial pathways; also sho |
|
DC20107 |
Blasticidin S hydrochloride
Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. |
3513-03-9 |
DC20801 |
BLT-1
Featured
BLT-1 is an irreversible Scavenger receptor class B member I (SR-BI) inhibitor that blocks SR-BI-mediated selective lipid uptake and bidirectional cholesterol flux with an IC50 of 50 nM; significantly inhibits baicalin-induced cholesterol efflux in THP-1 macrophages. |
321673-30-7 |
DC12650 |
BLU-667 trans form
BLU-667 trans form is the trans form of BLU-667, which is a highly potent, selective, next generation RET inhibitor.. |
2097132-93-7 |
DC11152 |
BLU-782
Featured
BLU-782 (BLU782) is a novel potent, selective inhibitor of Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of <10 Nm. |
2141955-96-4 |
DC23305 |
BM-1197
BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1. |
1391107-89-3 |
DC20802 |
BM-635
BM-635 is a small molecule anti-mycobacterial compound acting by inhibiting the mycobacterial membrane protein Large 3 (MmpL3). |
1073372-01-6 |
DC23304 |
BM-957
BM-957 is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively. |
1391107-54-2 |
DC8270 |
BML-277
Featured
BML-277 (C 3742) is a selective Chk2 (checkpoint kinase 2) inhibitor with an IC50 of 15 nM. |
516480-79-8 |
DC20321 |
Bm-MPK1-IN-15b
Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM. |
2222294-62-2 |
DC23833 |
SB 4 (Eticovo)
Featured
BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes. |
100874-08-6 |
DC20812 |
BMS 695735
BMS 695735 is a potent, selective IGF-1R inhibitor with IC50 of 34 nM. |
1054315-48-8 |
DC22988 |
BMS-189453
Featured
BMS-189453 (BMS189453, BMS453) is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ. |
166977-43-1 |
DC22032 |
BMS-211
BMS-211 is a prodrug of the parent pan-CK2 inhibitor BMS-699.. |
|
DC11294 |
BMS-212
BMS-212 is a potent and selective stimulator of glucokinase (GK) (EC50 = 35 nM) that is promisingly used as an antidiabetic. |
2173153-38-1 |
DC10200 |
BMS-214662
BMS-214662 is a potent and selective farnesyl transferase inhibitor with potent antitumor activity with an IC50 of 1.35 nM. |
195987-41-8 |
DC7375 |
BMS-303141
Featured
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor with IC50 value of 0.13 uM (human recombinant ACL). |
943962-47-8 |
DC20808 |
BMS-394136
BMS-394136 is a potent, selective IKur/Kv1.5inhibitor, increases atrial action potential duration (APD) and prolongs AERP but not VERP in both rabbits and beagles.. |
343246-73-1 |
DC20809 |
BMS433771
BMS433771 is a potent, orally active RSV fusion inhibitor, exhibits excellent potency against multiple laboratory and clinical isolates of both group A and B viruses with mean EC50 of 20 nM. |
543700-68-1 |
DC23529 |
BMS-457
BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM, >1,000-fold selectivity against other CC family receptors. |
946594-19-0 |
DC23167 |
BMS-564929
BMS-564929 is a potent, selective androgen receptor modulator (SARM) that binds to AR with Ki of 2.11 nM. |
627530-84-1 |
DC7897 |
BMS-582949 HCl
Featured
BMS-582949 is a dual action p38 Kinase Inhibitor. |
623152-17-0 |
DC22033 |
BMS-595
BMS-595 (BMS595) is a novel potent, selective, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50 of 1.3 nM (CKα). |
|
DC24131 |
BMS-599626 hydrochloride
BMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM. |
873837-23-1 |
DC7730 |
Temsavir(BMS-626529)
Featured
BMS-626529 is a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T-cells. |
701213-36-7 |
DC20805 |
BMS-641988
BMS-641988 is a potent, selective, nonsteroidal androgen receptor antagonist with Ki of 1.7 nM, MDA-MB-453 cell IC50 of 16 nM. |
573738-99-5 |
DC20811 |
BMS-654457
BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM. |
1004551-41-0 |
DC22034 |
BMS-699
BMS-699 (BMS699) is a novel potent, selective, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50 of 0.1 nM (CKα). |
|
DC23482 |
BMS-741672
BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.. |
1004757-96-3 |
DC20813 |
BMS-751324
BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM. |
948842-66-8 |
DC20814 |
BMS-795311
BMS-795311 is a potent and orally available CETP inhibitor with IC50 of 3.8 nM, inhibits cholesteryl ester (CE) transfer with IC50 of 0.22 uM. |
939390-99-5 |
DC7089 |
BMS-806 (BMS 378806)
BMS-806 (BMS 378806) is a small molecule gp120/CD4 inhibitor with an IC50 of median 5 nM. |
357263-13-9 |
DC10494 |
BMS813160
Featured
BMS-813160 is a dual CCR2/CCR5 chemokine antagonist. |
1286279-29-5 |
DC12670 |
BMS-817378 free base
Featured
BMS-817378 is a prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833. |
1174161-69-3 |
DC23526 |
BMS-817399
BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1 nM, inhibits MIP-1α-induced chemotaxis with IC50 of 6 nM. |
1202400-18-7 |
DC12635 |
BMS-818251
BMS-818251 (BMS818251) is a novel potent, small-molecule inhibitor of HIV-1 entry with EC50 of 0.019 nM against e laboratory-adapted HIV-1 strain NL4-3. |
|
DC20815 |
BMS-823778
Featured
BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2. |
1140898-87-8 |
DC12512 |
BMS-823778 free base
BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2. |
1140897-32-0 |
DC7090 |
BMS-863233 (XL-413)
Featured
BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. |
1169562-71-3 |
DC23891 |
BMS-869780
BMS-869780 is a potent γ-secretase modulator (GSM) that decreases Aβ1-42 (IC50=5.1 nM) and Aβ1-40 (IC50=25.1 nM) and increases Aβ1-37 and Aβ1-38 without inhibiting overall levels of Aβ peptides or other APP processing intermediates. |
1235493-78-3 |
DC20817 |
BMS-871
BMS-871 is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively. |
1584631-89-9 |
DC20818 |
BMS-884775
BMS-884775 is a potent, selective P2Y1 antagonist with IC50 of 0.12 nM. |
1557206-59-3 |
DC20819 |
BMS-919373
BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration. |
1272353-82-8 |
DC23872 |
BMS-932481(BMS932481;BMS 932481)
Featured
BMS-932481 (BMS932481) is a potent, selective, orraly active γ-secretase modulator (GSM), shows selectivity for Aβ40 and Aβ42 reduction (IC50=6.6 nM) while sparing total Aβ levels both in vitro and in vivo. |
1263871-36-8 |
DC22445 |
BMS-933043
BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively. |
1221973-93-8 |
DC23411 |
BMS-952048(BMS952048;BMS 952048)
BMS-952048 is a positive allosteric modulator of mGluR5 with EC50 of 10 nM.. |
1375751-32-8 |
DC21092 |
BMS-955176
Featured
BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses. |
1392312-45-6 |
DC20820 |
BMS-961955
BMS-961955 is an potent, allosteric inhibitor of HCV NS5B polymerase with EC50 of 7.9/4.3 nM for GT 1b/1a replicon respectively. |
1431328-92-5 |
DC20821 |
BMS-962212
Featured
BMS-962212 is a potent, highly selective and reversible small molecule coagulation Factor XIa (FXIa) inhibitor with Ki of 0.7 nM. |
1430114-34-3 |
DC23143 |
BMS-983970
BMS-983970 (BMS983970) is a potent, orally active, pan-Notch inhibitor, demonstrates robust anti-tumor activity at tolerated doses in multiple tumor xenograft models.. |
1584713-87-0 |
DC22035 |
BMS-984923
BMS-984923 (BMS-984923) is a potent silent allosteric modulator (SAM) of mGluR5 with competitive antagonism of MPEPy binding with Ki of 0.6 nM, but has no detectable agonist and antagonist activity at mGluR5 signaling. |
1375755-46-6 |
DC23873 |
BMS-986115
BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity. |
1584647-27-7 |
DC23459 |
BMS-986118
BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM). |
1610562-74-7 |
DC26073 |
BMS-986122
Featured
BMS-986122 is a potent positive allosteric modulator of μ-opioid receptor, significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by an EC10 (30 pM) concentration of endomorphin-I in CHO-μ cells.. |
313669-88-4 |
DC23609 |
BMS-986163
BMS-986163 is a water-soluble phosphate prodrug of BMS-986169, which is a novel GluN2B negative allosteric modulator (Ki=4.0 nM).. |
1801151-09-6 |
DC12174 |
Deucravacitinib(BMS986165)
Featured
BMS-986165 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2). |
1609392-27-9 |
DC23532 |
BMS-986166
Featured
BMS-986166 (BMS986166) is a potent, selective S1P receptor modulator for the treatment of ulcerative colitis.. |
1883345-06-9 |
DC23639 |
BMS-986169
BMS-986169 is a novel GluN2B negative allosteric modulator, demonstrates high binding affinity for the GluN2B allosteric site (Ki=4.0 nM) and selective inhibition of GluN2B receptor function (IC50=24 nM) in cells. |
1801151-08-5 |
DC23460 |
BMS986187
Featured
BMS-986187 is a novel potent, positive allosteric modulator of δ-opioid receptor with EC50 of 30 nM, 100-fold selectivity over μ-opioid receptor.. |
684238-37-7 |
DC22036 |
BMT-046091
BMT-046091 (BMT046091) is a potent and selective AAK1 inhibitor with IC50 of 2.8 nM. |
1551401-20-7 |
DC23998 |
BMX-IN-1
Featured
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity. |
1431525-23-3 |
DC23754 |
BNC-1
BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2. |
96335-59-0 |
DC7773 |
BNC-105
Featured
BNC105 is a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. |
945771-74-4 |
DC23262 |
BNM-III-170
BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo. |
1859189-54-0 |
DC23243 |
BNM-III-170 trifluoroacetate
BNM-III-170 TFA salt is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo. |
1859189-55-1 |
DC20823 |
BNS-22
BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively. |
1151668-24-4 |
DC22037 |
Bobcat339
Featured
Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
2280037-51-4 |
DC23218 |
BOC-D-FMK
Featured
BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM. |
634911-80-1 |
DC20034 |
Boc-MLF TFA
Boc-MLF (TFA) is a peptide, used as a specific formyl peptide receptor (FPR) antagonist, also inhibits the signaling through formyl peptide receptor like 1 (FPRL1) at higher concentrations. |
|
DC8073 |
Bohemine
Featured
Bohemine is a synthetic, cell-permeable, cyclin-dependent kinase inhibitor. |
189232-42-6 |
DC21869 |
Borussertib
Featured
Borussertib is a potent, first-in-class, covalent-allosteric AKT inhibitor. |
1800070-77-2 |
DC12405 |
BOS172722
Featured
BOS172722 (BOS-172722) is a potent, selective MPS1 kinase inhibitor with biochemical IC50 of 11 nM, 100-fold selectivity over CDK2. |
1578245-44-9 |
DC5164 |
Bosutinib (SKI-606)
Featured
Bosutinib is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. |
380843-75-4 |
DC23896 |
Box5
Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist. |
881188-48-3 |
DC20322 |
BPIPP
BPIPP is an inhibitor of GC-C (guanylyl cyclase type C) that inhibits stimulation of guanylyl cyclase and adenylyl cyclase, suppresses cGMP accumulation in a variety of cell lines (IC50=3.4-11.2 uM). |
325746-94-9 |
DC12608 |
BPN14770
Featured
BPN14770 (BPN-14770) is an allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 and 7.4 nM for human PDE4D7 and PDE4D3 respectively, displays 16-fold less potent against monomeric form of PDE4D lacking the UCR1 dimerization domain (PDE4D2 |
1606975-12-5 |
DC23884 |
BPN-15606
BPN-15606 (BPN15606) is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 by SHSY5Y neuroblastoma cells with IC50 of 7 nM. |
1914989-49-3 |
DC8294 |
BPR1J-097
Featured
BPR1J-097 is a novel small molecule FLT-3 inhibitor(IC50=11±7 nM) with promising in vivo anti-tumour activities; inhibits FLT-3 D835Y with an IC50 of 3 nM. |
1327167-19-0 |
DC21870 |
BPR1J373
BPR1J373 is a potent, orally available multitargeted kinase inhibitor, potently inhibits FLT3, c-KIT, VEGFR1-3, Aurora A, PDGFRα, PDGFRβ, RET, and SRC with IC50 values of <100 nM. |
|
DC20825 |
BPR1K653
BPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively. |
1192754-06-5 |
DC7951 |
Glutaminase Inhibitor II, BPTES
Featured
BPTES is a selective inhibitor of Glutaminase GLS1 (KGA) |
314045-39-1 |
DC7542 |
BQ-788
Featured
BQ-788 sodium salt is a potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells); poorly inhibited the binding to ET A receptors in human neuroblastoma cell line SK-N-MC cells (IC(50), 1300 nM). |
156161-89-6 |
DC10515 |
BQCA
Featured
BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5. |
338747-41-4 |
DC23763 |
BQU-082
BQU-082 is a novel potent small GTPase Ral (Ras-like) inhibitor with IC50 of 1.7 uM, displays a dose dependent effect on RalA and RalB activity in H2122 spheroids using the common RalBP1 pull-down assay.. |
1854910-73-8 |
DC8202 |
BQU57
Featured
BQU57 is a potent and selective GTPase Ral Inhibitor. |
1637739-82-2 |
DC12641 |
BR101549
BR101549 (BR-101549) is a novel PPARγ non-TZD agonist with EC50 of 1.73 uM (Amax 120%).. |
2252478-54-7 |
DC23555 |
BR103
BR103 is a potent, metabolically stable and highly selective small molecule agonist of complement C3a receptor (C3aR) with EC50 of 22 ± 8 nM. |
1434873-26-3 |
DC23547 |
BR111
BR111 is a potent, highly selective and orally active antagonist of complement C3a receptor (C3aR) with IC50 of 85 ± 40 nM (inhibition of hC3a induced Ca2+ release on human macrophages). |
1037092-93-5 |
DC20092 |
BR351
BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively. Potential tools for the molecular imaging of activated MMPs with PET. |
960113-85-3 |
DC20096 |
BR351 precursor
BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively. Potential tools for the molecular imaging of activated MMPs with PET. |
960113-89-7 |
DC20827 |
BRACO-19
BRACO-19 is a potent small molecule Telomerase inhibitor (IC50=115 nM) that inhibits expression of human telomerase reverse transcriptase (hTERT). |
1177798-88-7 |
DC7809 |
BRACO19 trihydrochloride
Featured
BRACO19 is a telomerase inhibitor that stabilizes G-quadruplexes, targeting telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest. |
351351-75-2 |
DC20323 |
Bractoppin
Featured
Bractoppin is a potent, small-molecule chemical inhibitor that specific selectively blocks phosphopeptide recognition by the BRCA1 tBRCT domain with binding IC50 of 74 nM; shows no inhibition for recognition of cognate biotinylated phosphopeptides to the TOPBP1 tBRCT 7/8, or GRB2 SH2 proteins; engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket; inhibits substrate recognition detected by Förster resonance energy transfer, and diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51; selectively interrupts BRCA1 tBRCT-dependent signals evoked by DNA damage. |
2290527-07-8 |
DC7775 |
Bradanicline (TC-5619)
Featured
Bradanicline (TC-5619) is an experimental pharmaceutical drugthat acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. |
639489-84-2 |
DC23752 |
Bragsin1(Bragsin 1)
Bragsin1 (Bragsin 1) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM). |
369631-68-5 |
DC12375 |
Bragsin2
Featured
Bragsin2 is a novel PH-domain-binding inhibitor,inhibiting BRAG2-mediated Arf GTPase activation. |
342795-08-8 |
DC9839 |
Brassinin
Featured
Brassinin is a Inducer of phase II enzymes. Moderate and competitive indoleamine 2,3-dioxygenase inhibitor (Ki = 98 μM). Shows chemopreventive effects in vivo. Orally active. |
105748-59-2 |
DC23100 |
Brassinolide
Featured
Brassinolide is a predominant plant growth modulator that regulate plant cell elongation. It is active against herpes and arena viruses. |
72962-43-7 |
DC23796 |
BRD 0476
BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival. |
1314958-91-2 |
DC20842 |
BRD 7389
Featured
BRD 7389 is an inhibitor of ribosomal S6 kinases (RSK) with IC50 of 1.5 uM, 2.4 uM, and 1.2 uM for RSK1, RSK2, and RSK3, respectively. |
376382-11-5 |
DC20843 |
BRD 8184
BRD 8184 is a potent, selective HDAC6 inhibitor with IC50 of 8 nM, weakly inhibits HDAC2 and HDAC8 (IC50=0.34 and 1.33 uM),has no activity for HDAC4 (IC50>30 uM).. |
1423058-83-6 |
DC20844 |
BRD 8430
BRD 8430 is a potent, selective class I HDAC inhibitor (HDAC1>2 >3) with IC50 of 69 nM/560/1300 nM for HDAC1/2/3, respectively. |
1482499-16-0 |
DC20845 |
BRD 8899
BRD 8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP). |
1404437-50-8 |
DC23341 |
BRD 9876
BRD 9876 is an ATP- and ADP-competitive Eg5 (kinesin-5) inhibitor with Ki of 4 nM, selectively inhibits microtubule-bound Eg5 and inhibits multiple myeloma cell growth (IC50=2.2 uM). |
32703-82-5 |
DC20828 |
BRD0209
BRD0209 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 19 nM/5 nM for GSK3α/GSK3β respectively. |
1597439-87-6 |
DC20838 |
BRD0705
Featured
BRD0705 is a potent, paralog-selective GSK3α inhibitor with IC50 of 66 nM, 8-fold selectivity over GSK3β (IC50=515 nM). |
2056261-41-5 |
DC23008 |
BRD10330
BRD10330 (BRD-10330) is a small molecule that upregulates IL-10 production in BMDCs. |
2174006-11-0 |
DC20829 |
BRD1172
BRD1172 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 3 nM/10 nM for GSK3α/GSK3β, respectively.. |
1597438-86-2 |
DC23561 |
BRD1240
BRD1240 is a small-molecule probe that can suppress V-ATPase function, inhibits lysosomal acidification and blocks the maturation of autophagosomes to autolysosomes. |
1304759-66-7 |
DC20830 |
BRD1652
BRD1652 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 0.4 nM/4 nM for GSK3α/GSK3β respectively. |
1597438-92-0 |
DC20831 |
BRD2492
Featured
BRD2492 is a highly potent, selective HDAC1/2 inhibitor (IC50=2/19 nM, respectively) that displays excellent selectivity versus HDAC3 (IC50=2.08 uM, ≥110-fold selectivity) and all other HDAC isoforms, increases caspase-3 activation.. |
1821669-43-5 |
DC22038 |
BRD2879
BRD2879 (BRD-2879) is a potent, selective inhibitor of IDH1-R132H mutant with IC50 of 50 nM, inhibits cell-based production of R-2HG with EC50 of 0.3 uM. |
1304750-47-7 |
DC20832 |
BRD3308
Featured
BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms. |
1550053-02-5 |
DC20839 |
BRD3731
BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM). |
2056262-08-7 |
DC12426 |
BRD4 inhibitor Compound V
BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively. |
|
DC23880 |
BRD50837
BRD50837 is a potent, selective, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 90 nM, partially lowers Gli1 expression at concentrations of 2 uM, a useful probe of Shh signaling pathway. . |
1314295-24-3 |
DC20833 |
BRD5459
BRD5459 is a nontoxic enhancer of reactive oxygen species (ROS) that strongly elevates markers of oxidative stress without causing cell death, ROS inducer.. |
612037-58-8 |
DC20840 |
BRD5529
BRD5529 is a small-molecule inhibitor that disrupts the interaction of CARD9-E3 ubiquitin ligase TRIM62 with IC50 of 8.6 uM. |
1358488-78-4 |
DC20834 |
BRD56491
BRD56491 is a nontoxic enhancer of reactive oxygen species (ROS) that strongly elevates markers of oxidative stress without causing cell death, ROS inducer.. |
14756-26-4 |
DC22711 |
BRD5814
Featured
BRD5814 is a potent, selective, highly brain penetrant β-arrestin biased dopamine D2 receptor (D2R) antagonist with Ki of 0.27 uM. |
1953181-29-7 |
DC23885 |
BRD6851
BRD6851 is a potent, cell-active Hedgehog (Hh) pathway inhibitor with IC50 of 0.4 uM against C3H10T1/2 cells undergoing Hh-induced activation acts predominantly as Smo antagonist. |
1396152-06-9 |
DC8409 |
BRD7552
Featured
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. |
1137359-47-7 |
DC20836 |
BRD9092
BRD9092 is a nontoxic enhancer of reactive oxygen species (ROS) that strongly elevates markers of oxidative stress without causing cell death, ROS inducer.. |
330662-92-5 |
DC23874 |
BRD9526
BRD9526 is a potent, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 60 nM, partially lowers Gli1 expression at concentrations of 10 uM, a useful probe of Shh signaling pathway. . |
1446352-30-2 |
DC20837 |
BRD9757
BRD9757 is a potent, selective HDAC6 inhibitor with IC50 of 8 nM, displays >20-fold selectivity over HDAC1/3 and other HDAC isoforms.. |
1423058-85-8 |
DC23373 |
BRD9-IN-28
BRD9-IN-28 is a highly potent and selective BRD7/9 bromodomain inhibitor with pIC50 of 6.9, Kd of 68 nM for BRD9. |
1947372-67-9 |
DC23356 |
BRD-IN-17
BRD-IN-17 is a cell permeable, family VIII bromodomain tool compound with additional PB1(2) activity over and above that of PFI-3. |
1914047-59-8 |
DC23367 |
BRD-IN-26
BRD-IN-26 is a potent bromodomain inhibitor that binds the fifth bromodomain of PB1 with a KD of 124 nM, SMARCA2B and SMARCA4 with KD values of 262 and 417 nM, respectively. |
1915012-19-9 |
DC2091 |
Brefeldin A
Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells. |
20350-15-6 |
DC20981 |
Brequinar sodium
Featured
Brequinar sodium (DuP-785, Brequinar, NSC 368390) is a potent and selective inhibitor of DHODH with IC50 of 20 nM, triggers differentiation in the ER-HoxA9, U937, and THP1 cells with an ED50 of 1 uM. |
96201-88-6 |
DC8179 |
Briciclib(ON 013105,ON 014185)
Featured
Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. |
865783-99-9 |
DC23147 |
Brigatinib (AP-26113)
Featured
Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM, exhibits about fivefold greater potency in vitro compared with crizotinib. |
1197953-54-0 |
DC4165 |
Brinzolamide
Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM. |
138890-62-7 |
DC9535 |
Brivaracetam
Featured
Brivaracetam(UCB-34714) is a 4-substituted pyrrolidone butanamide as agent with significant antiepileptic activity; high affinity SV2A ligand and also shows an ability to inhibit Na+ channels. |
357336-20-0 |
DC10383 |
Brivudine
Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster. |
69304-47-8 |
DC21871 |
BRK inhibitor P21d
BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM). |
1338249-87-8 |
DC23461 |
BRL 37344 sodium
BRL 37344 is a potent and selective β3 adrenoceptor agonist with Ki of 287 nM. |
127299-93-8 |
DC7891 |
BRL 52537 HYDROCHLORIDE
BRL 52537 is a selective κ/μ opioid receptor agonist. |
112282-24-3 |
DC20180 |
BRL-50481
Featured
BRL-50481 is a novel and selective inhibitor of phosphodiesterase (PDE) 7 with a Ki value, derived from secondary (Dixon) plots, of 180±10 nM, being at least 200-fold selective for hrPDE7A1 over all other PDEs. |
433695-36-4 |
DC9124 |
Bromhexine HCl
Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. |
611-75-6 |
DC22426 |
Bromocriptine
Bromocriptine (2-Bromoergocriptine. |
25614-03-3 |
DC23899 |
Bromocriptine mesylate
Featured
Bromocriptine (CB-154) is a dopamine D2 receptor agonist (Ki=3 nM) and and various serotonin receptors, also inhibits the release of glutamate by reversing the glutamate GLT1 transporter. |
22260-51-1 |
DC8386 |
Bromodeoxyuridine (BrdU)
Featured
Bromodeoxyuridine (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA, and used in the detection of proliferating cells. |
59-14-3 |
DC7543 |
Bromosporine
Featured
Bromosporine is a broad spectrum bromodomain inhibitor. Accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM. |
1619994-69-2 |
DC12633 |
Bromotriazine
Bromotriazine (BTZ) is a covalent probe against bromodomain containing proteins with selectively targeting non-catalytic, highly conserved amino acid residues.. |
|
DC23385 |
BRPF1B TRIM24-IN-34
BRPF1B TRIM24-IN-34 is a selective BRPF1B/TRIM24 dual inhibitor that binds with KD of 137 and 222 nM, respectively. |
1242907-48-7 |
DC10460 |
BT-11
Featured
BT-11 is an orally active and selective LANCL2 modulator. |
1912399-75-7 |
DC10164 |
BTB-1
Featured
BTB-1 is a small molecule inhibitor of the mitotic motor protein Kif18A. |
86030-08-2 |
DC20199 |
BTK inhibitor 1;Compound 27
Featured
BTK inhibitor 1 (Compound 27) |
2230724-66-8 |
DC26026 |
Btk inhibitor 2
Btk inhibitor 2 is a Bruton's tyrosine kinase (BTK) inhibitor extracted from patent US 20170224688 A1. |
1558036-85-3 |
DC12432 |
BTK inhibitor 4b
BTK inhibitor 4b is a potent, highly selective inhibitors of BTK with IC50 of 4.2 and 0.9 nM against activated and unactivated BTK, respectively. |
1646608-10-7 |
DC11431 |
BTK-030
BTK-030 is a novel BTK inhibitor. |
2241732-30-7 |
DC23870 |
BTK-IN-23
BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM. |
1227206-13-4 |
DC23413 |
BTRX335140
Featured
BTRX-335140 (CYM-53093, BTRX335140, CYM53093) is a potent, selective, orally active κ opioid receptor (KOR) antagonist with IC50 of 0.8 nM. |
2244614-14-8 |
DC12456 |
BTT-266
Featured
BTT-266 (BTT266) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction, directly binds to CaVβ3 with Kd of 3.6 uM. |
2413939-89-4 |
DC12457 |
BTT-369
BTT-369 (BTT369) is a voltage-gated CaV2.2 calcium channel inhibitor that disrupts the CaVα·CaVβ3 protein-protein interaction with Ki of 2.0 uM in FP assays. |
|
DC23703 |
BTYNB
Featured
BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM. |
304456-62-0 |
DC22041 |
BTZO-1
Featured
BTZO-1 is a cardioprotective agent and Macrophage migration inhibitory factor (MIF) activator, binds to MIF with Kd of 68.6 nM, regulates ARE-mediated gene expression. |
99420-15-2 |
DC22042 |
BTZO-15
BTZO-15 is an active BTZO-1 derivative for ARE-activation with a favorable ADME-Tox profile, induces expression of heme oxygenase-1 (HO-1) and inhibits NO-induced cell death in IEC-18 cells. |
916799-65-0 |
DC22043 |
BTZO-2
BTZO-2 is an active BTZO-1 derivative, an antioxidant response element-activator, provides protection against lethal endotoxic shock in mice.. |
501375-54-8 |
DCAPI1209 |
Budesonide
Budesonide |
51333-22-3 |
DC6501 |
Bufalin
Featured
Bufalin inhibits steroid receptor coactivator 1 (SRC-1) and SRC-3 at doses as low as 5 nM, promotes the degradation of SRC-3 protein, and inhibits cancer cell growth both in vitro and in vivo. |
465-21-4 |
DCAPI1160 |
Buflomedil HCl
Buflomedil HCl |
35543-24-9 |
DCAPI1459 |
Bupivacaine HCL
Bupivacaine HCL |
18010-40-7 |
DC22437 |
Burimamide oxalate
Burimamide oxalate is a potent dual H3/H2 receptor antagonist with Ki of 0.07 and 7.8 uM, respectively. |
163932-06-7 |
DC20059 |
Burixafor hydrobromide (TG-0054 hydrobromide)
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist of CXCR4 and a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization. Burixafor hydrobromide (TG-0054 hydrobr |
1191450-19-7 |
DC8995 |
Busulfan/Myleran
Busulfan is a bifunctional alkylating agent. |
55-98-1 |
DCAPI1407 |
Butenafine
Butenafine |
101828-21-1 |
DC21685 |
BVT-948
Featured
BVT-948 (SPS8I-3) is a noncompetitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) with IC50 of 0.09-1.7 uM. Results show that the effect of BVT948 (BVT.948) is to strengthen the insulin signal and has no effects on the duration of th |
39674-97-0 |
DC20852 |
BX-320
BX-320 is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 30 nM, >20-fold selectivity over PKA. |
702676-93-5 |
DC8808 |
BX-513 hydrochloride
Featured
BX-513 hydrochloride inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). |
193542-65-3 |
DC8062 |
BX517
Featured
BX517 is a novel phosphoinositide-dependent kinase-1 (PDK1) inhibitor. |
850717-64-5 |
DC22424 |
BX-667
BX-667 is a potent P2Y12 receptor antagonist that blocks ADP-induced platelet aggregation in human, dog and rat blood (IC50=97, 317 and 3000 nM respectively). |
937395-08-9 |
DC7094 |
Alpelisib(BYL-719)
Featured
BYL719 is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, ;liitle or no effect on PI3Kβ/γ/δ. |
1217486-61-7 |
DC20853 |
BZ-194
BZ-194 is a small molecule inhibitor of NAADP action that inhibit NAADP-mediated Ca2+ signaling in T cells, neither interferes with Ca2+ mobilization by IP3 or cyclic ADP-ribose nor with capacitative Ca2+ entry. |
936356-28-4 |
DC20326 |
BzDANP
BzDANP is a small molecule modulator of pre-miR-29a maturation by Dicer, effectively stabilizes the C-bulged RNA and suppresses Dicer-mediated processing of pre-miR-29a in a concentration dependent manner.. |
1994258-88-6 |
DC26049 |
Bz-IEGR-pNA (acetate)
Featured
Bz-IEGR-pNA is a colorimetric substrate for Factor Xa. |
1325307-57-0 |
DC11453 |
Bz-Nle-Lys-Arg-Arg-AMC
Featured
Bz-Nle-Lys-Arg-Arg-AMC is a substrate for dengue virus NS2B-NS3 and yellow fever virus NS3 protease. |
863975-32-0 |
DC23462 |
C-021 dihydrochloride
C-021 dihydrochloride is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.. |
1784252-84-1 |
DC23414 |
C-021
C-021 is a potent and orally bioavailable CCR4 antagonist with IC50 of 0.14 uM and 0.039 uM for inhibition of chemotaxis in human and mouse, respectively.. |
864289-85-0 |
DC20855 |
C-215
C-215 is a novel inhibitor of mycobacterial membrane protein large 3 (MmpL3) with MIC90 of 16 uM against M. tuberculosis.. |
912780-51-9 |
DC20327 |
C450-0730
C450-0730 is a potent LuxN antagonist that antagonizes LuxN-AI-1 binding with IC50 of 2.7 uM. |
1036730-46-7 |
DC20328 |
C5-benzyl SAHA
C5-benzyl SAHA is a C5-modified SAHA analog that displays dual selectivity to HDAC6 (IC50=0.27 uM) and HDAC8 (IC50=0.38 uM) over HDAC 1, 2, and 3 (IC50=2.9-5.8 uM). |
2115700-64-4 |
DC12044 |
CA-5f
Featured
CA-5f is a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. |
1370032-19-1 |
DC26013 |
Cabotegravir Sodium
Featured
Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. |
1051375-13-3 |
DC8180 |
Cabotegravir(GSK744)
Featured
Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. |
1051375-10-0 |
DC10736 |
CaCC(inh)-A01
Featured
CaCC(inh)-A01 is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50 = 10 µM). |
407587-33-1 |
DC20856 |
CAD-031
Featured
CAD-031 (CAD31) is a novel brain penetrant, J147-derivative that has enhanced neurogenic activity over J147 in human neural precursor cells (NPCs). |
2071209-49-7 |
DC10457 |
Cadazolid (ACT-179811)
Featured
Cadazolid (ACT-179811) is a novel fluoroquinolone-oxazolidinone antibiotic and a protein synthesis inhibitor. |
1025097-10-2 |
DC10327 |
Calcitonin salmon
Featured
Calcitonin, Salmon is a calcium regulating hormone secreted from mammalian thyroid parafollicular cells and in non-mammalian species from the ultimobranchial gland. |
47931-85-1 |
DCAPI1351 |
Calcium levofolinate (Calcium Folinate)
Calcium levofolinate (Calcium Folinate) |
80433-71-2 |
DC12253 |
Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt)
Calcium polystyrene sulfonate is an ion-exchange resin used for reducing blood levels of potassium. Calcium polystyrene sulfonate is used to treat hyperkalemia in patients with chronic kidney disease (CKD). |
37286-92-3 |
DC20857 |
Calhex-231
Featured
Calhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM. |
652973-93-8 |
DC20329 |
Calindol hydrochloride
Calindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM (stimulated 3H IP accumulation in CHO cells at 2 mM Ca2+). |
729610-18-8 |
DC20021 |
Calmidazolium chloride (R 24571)
Featured
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer re |
57265-65-3 |
DC7095 |
W-7 hydrochloride
Featured
Calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM). |
61714-27-0 |
DC7967 |
calpeptin
Featured
calpeptin is Ca2+-dependent protease,calpain inhibitor |
117591-20-5 |
DC22045 |
CAM4066
CAM4066 (CAM-4066) is a potent and selective CK2α inhibitor with Kd of 0.32 uM and IC50 of 0.37 uM, shows significantly improved selectivity compared to other CK2α inhibitors. . |
2101206-81-7 |
DC22046 |
CAM4712
CAM4712 (CAM-4712) is a potent and selective CK2α inhibitor with IC50 of 7 uM, exhibits cell growth inhibition in HCT116 cell line with IC50 of 10 uM. |