DC22794 |
NSC112200
Featured
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NSC112200 is a chemical inhibitor of the EZH2 deubiquitinase ZRANB1 (at 10 uM), destabilizes EZH2, promotes proteasomal degradation of EZH2 and inhibits the viability of TNBC cells. |
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DC9872 |
NSC15364
Featured
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NSC15364 is an inhibitor of Shiga Toxin. |
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DC12657 |
NSC228155
Featured
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NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation. |
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DC9989 |
NSC23005 free acid
Featured
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NSC23005 is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. |
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DC12478 |
NSC 260594
Featured
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NSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging, which involves preventing the interaction of Gag with SL3 by stabilizing this small RNA stem-loop which then leads to stabilization of the global packaging signal region (psi or ψ). |
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DC9641 |
NSC348884
Featured
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NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. |
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DC12459 |
NSC49652 |
NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian c |
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DC20228 |
NSC617145(WRN inhibitor)
Featured
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NSC617145 is a Werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM). |
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DC22183 |
NSC668394 |
NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM. |
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DC10484 |
NSC781406
Featured
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NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα. |
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DC10212 |
NSC-87877 |
NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. |
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DC7165 |
NSI-189
Featured
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NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine. |
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DC21429 |
NTRC-844 |
NTRC-844 (NTRC844) is a potent, selective neurotensin receptor type 2 (NTS2) with Ki of 23 nM, 100-fold selectivity over NTS1 receptor. |
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DC5047 |
NU7026
Featured
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NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. |
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DC26038 |
NUC-1031(SP) |
NUC-1031(SP) is S form of NUC-1031 at P site.Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. |
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DC26034 |
NUC3373(Fosifloxuridine nafalbenamide)
Featured
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NUC-3373 is a phosphoramidate-based prodrug of the monophosphate form of 5-fluoro-2'-deoxyuridine, the active metabolite of fluorouracil,an antimetabolite fluoropyrimidine analog of the pyrimidine nucleoside, with potential antineoplastic activity. |
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DC26035 |
NUC-7738
Featured
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NUC-7738 is a phosphoramidate transformation of cordycepin (3’-deoxyadenosine; 3’-dA), a derivative of adenosine that was first isolated from Cordyceps sinensis. |
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DC9416 |
Nuclear yellow |
Nuclear yellow (Hoechst S769121) exhibits excitation/emission maxima ~335/495 nm when bound to DNA.
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DC21931 |
NV01 |
NV01 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain (TTD) with Kd of 5 uM.. |
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DC21932 |
NV03 |
NV03 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain with Kd of 2.4 uM.. |
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DC7988 |
NVP-DPP728 dihydrochloride |
NVP DPP 728 is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively. |
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DC21430 |
NVP-2
Featured
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NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 µM, 0.7 |
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DC8312 |
NVP-231 |
NVP-231 is a potent, specific, and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits binding of ceramide to CerK. |
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DC24053 |
NVP-BGJ398 phosphate
Featured
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NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ398 phosphate) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM. |
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DC8743 |
NVP-BVU972
Featured
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NVP-BVU972 is a selective and potent Met inhibitor (IC50 = 14 nM). Antitumor agents. |
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DC9769 |
NVP-CGM097 (CGM-097)
Featured
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NVP-CGM097 (CGM-097) is a potent and selective MDM2 inhibitor. |
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DC22564 |
NVP-MELK8a hydrochloride
Featured
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NVP-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM. |
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DC7474 |
NVP-QAV-572 |
NVP-QAV-572 is a potent PI3K kianse inhibitor with IC50 of 10 nM. |
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DC12583 |
NVR 3-778
Featured
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NVR 3-778 (NVR3-778, NVR 3778) is a small molecule inhibitor of HBV replication that targets the viral core protein, a first-in-class capsid assembly modulator. |
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DC24111 |
NVS-CRF38 |
NVS-CRF38 is a potent, selective, orally bioavailable corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50 of 70 nM.. |
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