NVP-231

Cas No.:	362003-83-6
Chemical Name:	N-​[2-​(benzoylamino)-​6-​benzothiazolyl]-​tricyclo[3.3.1.13,​7]decane-​1-​carboxamide
Synonyms:	NVP-231,NVP 231，NVP231
SMILES:	O=C(C1=CC=CC=C1)NC1=NC2=CC=C(NC(C34CC5CC(C3)CC(C5)C4)=O)C=C2S1
Formula:	C25H25N3O2S
M.Wt:	431.6
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

NVP-231 is a potent, reversible inhibitor of ceramide kinase (IC50 = 12 nM). It has minimal effect on several other lipid kinases, including sphingosine kinases 1 and 2.3 In cells in which exogenous short chain ceramide is converted to C1P, resulting in cell death, NVP-231 prevents both C1P synthesis and cell death.In mouse dermal microvascular endothelial cells, where ceramide kinase increases capillary-like tube formation, NVP-231 (100 nM) inhibits C1P formation as well as tube formation. For the detailed information of NVP-231, the solubility of NVP-231 in water, the solubility of NVP-231 in DMSO, the solubility of NVP-231 in PBS buffer, the animal experiment (test) of NVP-231, the cell expriment (test) of NVP-231, the in vivo, in vitro and clinical trial test of NVP-231, the EC50, IC50,and affinity,of NVP-231, For the detailed information of NVP-231, the solubility of NVP-231 in water, the solubility of NVP-231 in DMSO, the solubility of NVP-231 in PBS buffer, the animal experiment (test) of NVP-231, the cell expriment (test) of NVP-231, the in vivo, in vitro and clinical trial test of NVP-231, the EC50, IC50,and affinity,of NVP-231, Please contact DC Chemicals.