| DC21510 |
PI-273 |
PI-273 (PI273) is a potent, specific, substrate-competitive small molecule inhibitor of PI4KIIα with IC50 of 0.47 uM. |
|
| DC20090 |
PI3K/mTOR Inhibitor-1 |
PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual PI3K/mTOR inhibitor with IC50s of 20/376/204/46 nM and 186 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ and mTOR, respectively. Antitumor activity. |
|
| DC20036 |
PI3K/mTOR Inhibitor-2
Featured
|
PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR. Antitumor activity. |
|
| DC20503 |
PI3K-IN-16 |
PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively. |
|
| DC20504 |
PI3K-IN-8q |
PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively. |
|
| DC20499 |
PI3Kα-IN-4h |
PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively. |
|
| DC20500 |
PI3Kα-IN-5 |
PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ. |
|
| DC8531 |
TASP0415914
Featured
|
PI3Kγ is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally av |
|
| DC7874 |
PI3k(delta) inhibitor 1 |
PI3kδ inhibitor 1 is a potent and selective inhibitor of isoform of PI3Kδ; useful for treating disorders mediated by lipid kinases such as inflammation, immunol disorders, and cancer. |
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|
| DC20008 |
PI3Kδ-IN-1
Featured
|
PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM. |
|
| DC20502 |
PI3Kδ-IN-7n |
PI3Kδ-IN-7n is a highly potent and selective PI3Kδ inhibitor with IC50 of 0.9 nM, displays high selectivity (>1,500-fold) over PI3Kα, PI3Kβ, PI3Kγ (IC50>1.5 uM). |
|
| DC22508 |
PI4KIIIβ-IN-9 |
PI4KIIIβ-IN-9 is a potent and selective inhibitor of PI4KIIIβ (IC50=7 nM). |
|
| DC12466 |
PIAA |
PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells. |
|
| DC23700 |
Piclamilast |
Piclamilast (RP-73401) is a potent and highly selective PDE4 inhibitor with IC50 of 1.2 nM. |
|
| DC21511 |
Pico145 |
Pico145 is a highly potent, subtype-selective TRPC1/4/5 channels inhibitor with potency ranged from 9 to 1300 pM, depending on the TRPC1/4/5 subtype and activation mechanism. |
|
| DC7949 |
Picoxystrobin |
Picoxystrobin is an methoxyacrylate strobilurin fungicide designed for the control of wide range of cereal diseases. |
|
| DC8426 |
Picropodophyllin (PPP)
Featured
|
Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM. |
|
| DCAPI1426 |
Pidotimod
Featured
|
Pidotimod is a synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses. This compound has been shown to induce dendritic cell maturation and up-regulate the expression of HLA-DR and co-stimulatory molecu |
|
| DC9505 |
Pifithrin-α (hydrobromide)
Featured
|
Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
|
|
| DC8184 |
Pilaralisib(XL-147; SAR245408)
Featured
|
Pilaralisib (SAR245408; XL147) is selective oral pan-PI3K inhibitor. |
|
| DC21938 |
Pim inhibitor 28 |
Pim inhibitor 28 is a potent, selective inhibitor of Pim1/2 with IC50 of 0.05 nM for both, demonstrates on-target Pim activity in an in vivo pharmacodynamic assay with significant inhibition of BAD phosphorylation in KMS-12-BM multiple myeloma tumors.. |
|
| DC8243 |
Pimecrolimus
Featured
|
Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12. |
|
| DC23557 |
Pim-IN-22m |
Pim-IN-22m is a potent, selective Pim1/Pim2 inhibitor with IC50 of 24/95 pM respectively. |
|
| DC20505 |
Pimozide
Featured
|
Pimozide is an antipsychotic agent that acts as an antagonist of the D2, D3, and D4 receptors and the 5-HT7 receptor, also is an inhbitor of STAT5. |
|
| DC12584 |
API-1 |
Pin1 inhibitor API-1 (API-1) is a potent, specific inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) and inhibits Pin1 cis-trans isomerizing activity with IC50 of 72.3 nM, displays remarkable selectivity over other peptidyl-prolyl |
|
| DC21939 |
PIN1 inhibitor VS10 |
PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM, displays >2-fold more potency than ATRA. |
|
| DCAPI1533 |
Piperaquine Phosphate |
Piperaquine Phosphate |
|
| DC24186 |
Piperazine Erastin
Featured
|
Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.. |
|
| DC9629 |
Azaphen (dihydrochloride monohydrate) |
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. |
|
| DC23685 |
Piragliatin |
Piragliatin (RO 4389620. |
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