| DC23267 |
PF-3450074
Featured
|
PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro. |
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| DC23449 |
PF-3635659 |
PF-3635659 (PF-03635659) is a potent, very long dissociative half-life (slow off-rate, >1440 min) muscarinic M3 antagonist with Ki of 0.2 nM, shows potential for the treatment of chronic obstructive pulmonary disease (COPD).. |
|
| DC22797 |
PF-3644022
Featured
|
PF-3644022 is a potent and selective, freely reversible, ATP-competitive inhibitor of MAPKAP2 (MK2) with Ki of 3 nM. |
|
| DC8152 |
PF3845yne |
PF3845yne is a Alkyne analogues of PF3845. |
|
| DC21859 |
PF-3893787 |
PF-3893787 (ZPL 3893787) is a potent and selective H4 receptor antagonist with binding Ki of 2.4 nM. |
|
| DC8059 |
PF 429242
Featured
|
PF-429242 is a potent inhibitor of S1P(cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease) |
|
| DC21473 |
PF-4363467 |
PF-4363467 (PF 04363467) is a novel highly potent, brain penetrant dopamine D3/D2 receptor antagonist with Ki of 1.3/692 nM respectively, with high selectivity for D3R versus other biogenic amine receptors. |
|
| DC7229 |
PF-4708671
Featured
|
PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM. |
|
| DC23247 |
PF-4776548 |
PF-4776548 (PF-04776548) novel HIV integrase inhibitor for treatment of HIV infections.. |
|
| DC22195 |
PF-6689840 |
PF-6689840 (PF6689840) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 54 nM in biochemical assays. |
|
| DC21830 |
PF-6808472 |
PF-6808472 (XO44) is a sulfonyl fluoride chemical probe that covalently labels a broad swath of the intracellular kinome with high efficiency. |
|
| DC21504 |
PF-719
Featured
|
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells. |
|
| DC21505 |
PF-9184 |
PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM. |
|
| DC10783 |
PF-9366
Featured
|
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. |
|
| DC21506 |
PFE-360 |
PFE-360 is a novel potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM. |
|
| DC8026 |
PFK-015
Featured
|
PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancer cells with IC50 of 20 nM. |
|
| DC10451 |
PFK158
Featured
|
PFK-158 is a potent and selective inhibitor of PFKFB3 that is currently being investigated in a phase I study in patients with advanced solid malignancies. |
|
| DC23255 |
PfKRS1 inhibitor 5 |
PfKRS1 inhibitor 5 is a potent, selective, oral inhibitor of P. falciparum lysyl-tRNA synthetase (PfKRS1) with IC50 of 15 nM, displays >100-fold selectivity over Human KRS (HsKRS, IC50=1.8 uM). |
|
| DC21665 |
PFM01
Featured
|
PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupt |
|
| DC21666 |
PFM39 |
PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ.. |
|
| DC20496 |
PGC-1α activator C80 |
PGC-1α activator C80 is a potent PGC-1α acetylation activator with AC50 of 3.1 uM, induces Pck1 and G6pc expression with AC50 of 11.9 uM and 12.8 uM, reduces glucose production in hepatocytes.. |
|
| DC12552 |
PGN9856
Featured
|
PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows higi selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors; displays a potency (pEC50 >8.5) and a maximal response (increase in cAMP) comp |
|
| DC20007 |
P-gp inhibitor 1 |
P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. |
|
| DC20498 |
PG-S3-001 |
PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance. |
|
| DC10794 |
PH-002
Featured
|
PH-002 is a small-molecule structure corrector,inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction,a potent candidate drug for the treament of AD(Alzheimer disease) |
|
| DC7727 |
PH-797804
Featured
|
PH-797804 is a potent and selective p38 inhibitor with IC50 of 26 nM. |
|
| DC8955 |
Phenacetin |
Phenacetin is a non-opioid analgesic without anti-inflammatory properties. |
|
| DC8999 |
Phenazopyridine hydrochloride |
Phenazopyridine Hcl is a chemical, which has a local analgesic effect, often used to alleviate the pain, irritation, discomfort, or urgency caused by urinary tract infections, surgery, or injury to the urinary tract. |
|
| DC8145 |
Phen-DC 3 |
Phen-DC 3|Phen-DC-3,Phen-DC3|DC Chemicals |
|
| DC8990 |
Phenformin hydrochloride |
Phenformin, an anti-diabetic drug, has demonstrated antitumor activity both in vitro and in vivo. |
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