| DC21504 |
PF-719
Featured
|
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells. |
|
| DC21505 |
PF-9184 |
PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM. |
|
| DC10783 |
PF-9366
Featured
|
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. |
|
| DC21506 |
PFE-360 |
PFE-360 is a novel potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM. |
|
| DC8026 |
PFK-015
Featured
|
PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancer cells with IC50 of 20 nM. |
|
| DC10451 |
PFK158
Featured
|
PFK-158 is a potent and selective inhibitor of PFKFB3 that is currently being investigated in a phase I study in patients with advanced solid malignancies. |
|
| DC23255 |
PfKRS1 inhibitor 5 |
PfKRS1 inhibitor 5 is a potent, selective, oral inhibitor of P. falciparum lysyl-tRNA synthetase (PfKRS1) with IC50 of 15 nM, displays >100-fold selectivity over Human KRS (HsKRS, IC50=1.8 uM). |
|
| DC21665 |
PFM01
Featured
|
PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, blocks the ssDNA-binding path toward the catalytic metal ions and disrupt |
|
| DC21666 |
PFM39 |
PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ.. |
|
| DC20496 |
PGC-1α activator C80 |
PGC-1α activator C80 is a potent PGC-1α acetylation activator with AC50 of 3.1 uM, induces Pck1 and G6pc expression with AC50 of 11.9 uM and 12.8 uM, reduces glucose production in hepatocytes.. |
|
| DC12552 |
PGN9856
Featured
|
PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows higi selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors; displays a potency (pEC50 >8.5) and a maximal response (increase in cAMP) comp |
|
| DC20007 |
P-gp inhibitor 1 |
P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. |
|
| DC20498 |
PG-S3-001 |
PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance. |
|
| DC10794 |
PH-002
Featured
|
PH-002 is a small-molecule structure corrector,inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction,a potent candidate drug for the treament of AD(Alzheimer disease) |
|
| DC7727 |
PH-797804
Featured
|
PH-797804 is a potent and selective p38 inhibitor with IC50 of 26 nM. |
|
| DC8955 |
Phenacetin |
Phenacetin is a non-opioid analgesic without anti-inflammatory properties. |
|
| DC8999 |
Phenazopyridine hydrochloride |
Phenazopyridine Hcl is a chemical, which has a local analgesic effect, often used to alleviate the pain, irritation, discomfort, or urgency caused by urinary tract infections, surgery, or injury to the urinary tract. |
|
| DC8145 |
Phen-DC 3 |
Phen-DC 3|Phen-DC-3,Phen-DC3|DC Chemicals |
|
| DC8990 |
Phenformin hydrochloride |
Phenformin, an anti-diabetic drug, has demonstrated antitumor activity both in vitro and in vivo. |
|
| DCAPI1358 |
Phenindione(Rectadione) |
Phenindione(Rectadione) |
|
| DC1110 |
Phenprocoumon (Marcumar) |
Phenprocoumon is closely related to warfarin and is an anticoagulant drug used to thin the blood, or stop it from clotting. |
|
| DC9054 |
phenylbutazone |
Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. |
|
| DC9449 |
Phenylpiracetam |
Phenylpiracetam(Phenotropyl; Phenotropil) is a phenylated derivative of the nootropic drug piracetam. |
|
| DC20127 |
PhiKan 083 |
PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells. |
|
| DC8671 |
Phosalone |
Phosalone is a member of the organophosphate family of insecticides. It is used as both an insecticide and acaricide. |
|
| DC20255 |
Phosphate and amino acid prodrug of Atazanavir |
Phosphate and amino acid prodrug of Atazanavir gives four-fold improved AUC and eight-fold higher Ctrough values of Atazanavir. |
|
| DC21508 |
Phosphonoacetohydroxamate |
Phosphonoacetohydroxamate (PhAH) is a potent Enolase inhibitor with IC50 of 53.2 nM and 62.3 nM for recombinant hENO1 and hENO2 respectively. |
|
| DC23766 |
Phox-I1 |
Phox-I1 is a small molecule inhibitor that targets the interactive site of p67(phox) with Rac GTPase with Kd of 100 nM. |
|
| DC23040 |
Jatrorrhizine
Featured
|
Phytochemical alkaloid found in medicinal plants. Anti-inflammatory. Exhibits neuroprotective, antioxidative and gastrointestinal modulatory activities. |
|
| DC21062 |
GPI-16552 |
PI-16552 is a potent, specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with IC50 of 1.7 uM. |
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