Home > Inhibitors & Agonists > Others > Other Targets
Cat. No. Product name CAS No.
DC10603 NSC 247030(SU5201) Featured

NSC 247030 is a bioactive chemical.

114727-43-4
DC21009 NSC 306711

NSC 306711 (Ferristatin, NSC306711) is a small-molecule iron transport inhibitor that promotes degradation of the transferrin receptor independent of clathrin and dynamin, is sensitive to the cholesterol-depleting agents filipin and nystatin..

813419-93-1
DC21420 NSC 311068

NSC 311068 is a small molecule that directly tragets and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.

66474-53-1
DC21421 NSC 368262

NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers.

299421-08-2
DC21422 NSC 370284 Featured

NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.

116409-29-1
DC10599 NSC 409012 Featured

NSC 409012 is a bioactive chemical.

90947-00-5
DC21423 NSC 45576

NSC 45576 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 1.7 uM.

1414586-62-1
DC10703 NSC 6038 Featured

NSC 6038 is a bioactive compound.

2447-87-2
DC20480 NSC 625987 Featured

NSC 625987 is a potent, selective CDK4 inhibitor with IC50 of 0.2 uM, displays >500-fold selectivity over CDK2 (IC50 >100 uM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E). .

141992-47-4
DC23790 NSC 630668

NSC 630668 is a Hsc70 inhibitor that inhibits the endogenous and DnaJ-stimulated ATPase activity of hsc70.

330846-35-0
DC23024 NSC 65828 Featured

NSC 65828 (NCI65828) is a small-molecule inhibitor of the ribonucleolytic activity of human angiogenin with Ki of 81 uM.

501444-06-0
DC23822 NSC 658497

NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity.

909197-38-2
DC21683 NSC 663284 Featured

NSC 663284 (SPS8I1;DA3003-1) is a potent inhibitor of the dual specificity protein phosphatase Cdc25 with Ki of 9/95//89 nM for Cdc25A/Cdc25B2/Cdc25C, displays 20- and 450-fold more selective over VHR or PTP1B phosphatases.

383907-43-5
DC23296 NSC 745887

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways.

54490-26-5
DC10697 NSC 80538 Featured

NSC 80538 is a bioactive compound.

370-26-3
DC22794 NSC112200 Featured

NSC112200 is a chemical inhibitor of the EZH2 deubiquitinase ZRANB1 (at 10 uM), destabilizes EZH2, promotes proteasomal degradation of EZH2 and inhibits the viability of TNBC cells.

28293-38-1
DC9872 NSC15364 Featured

NSC15364 is an inhibitor of Shiga Toxin.

4550-72-5
DC12657 NSC228155 Featured

NSC228155 is an activator of EGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.

113104-25-9
DC9989 NSC23005 free acid Featured

NSC23005 is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.

6314-70-1
DC12478 NSC 260594 Featured

NSC260594 (NSC 260594) is a specific inhibitor of HIV-1 RNA packaging, which involves preventing the interaction of Gag with SL3 by stabilizing this small RNA stem-loop which then leads to stabilization of the global packaging signal region (psi or ψ).

906718-66-9
DC9641 NSC348884 Featured

NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication.

81624-55-7
DC12459 NSC49652

NSC49652 (NSC 49652) is a compound targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian c

908563-68-8
DC20228 NSC617145(WRN inhibitor) Featured

NSC617145 is a Werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM).

203115-63-3
DC22183 NSC668394

NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM.

382605-72-3
DC10484 NSC781406 Featured

NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα.

1676893-24-5
DC10212 NSC-87877

NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

56990-57-9
DC7165 NSI-189 Featured

NSI-189 is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.

1270138-40-3
DC21429 NTRC-844

NTRC-844 (NTRC844) is a potent, selective neurotensin receptor type 2 (NTS2) with Ki of 23 nM, 100-fold selectivity over NTS1 receptor.

1811503-67-9
DC5047 NU7026 Featured

NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.

154447-35-5
DC26038 NUC-1031(SP)

NUC-1031(SP) is S form of NUC-1031 at P site.Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine.

1562406-27-2
DC26034 NUC3373(Fosifloxuridine nafalbenamide) Featured

NUC-3373 is a phosphoramidate-based prodrug of the monophosphate form of 5-fluoro-2'-deoxyuridine, the active metabolite of fluorouracil,an antimetabolite fluoropyrimidine analog of the pyrimidine nucleoside, with potential antineoplastic activity.

1332837-31-6
DC26035 NUC-7738 Featured

NUC-7738 is a phosphoramidate transformation of cordycepin (3’-deoxyadenosine; 3’-dA), a derivative of adenosine that was first isolated from Cordyceps sinensis.

2348493-39-8
DC9416 Nuclear yellow

Nuclear yellow (Hoechst S769121) exhibits excitation/emission maxima ~335/495 nm when bound to DNA.

74681-68-8
DC21931 NV01

NV01 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain (TTD) with Kd of 5 uM..

902908-03-6
DC21932 NV03

NV03 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain with Kd of 2.4 uM..

DC7988 NVP-DPP728 dihydrochloride

NVP DPP 728 is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively.

207556-62-5
DC21430 NVP-2 Featured

NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 µM, 0.7

1263373-43-8
DC8312 NVP-231

NVP-231 is a potent, specific, and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits binding of ceramide to CerK.

362003-83-6
DC24053 NVP-BGJ398 phosphate Featured

NVP-BGJ398 phosphate (Infigratinib phosphate, BGJ398 phosphate) is a potent, selective pan-FGFR inhibitor with IC50 of 0.9/1.0/1.4/60 nM for FGFR1/2/3/4, also shows high potenct against mutant FGFR3-K650E with IC50 of 4.9 nM.

1310746-10-1
DC8743 NVP-BVU972 Featured

NVP-BVU972 is a selective and potent Met inhibitor (IC50 = 14 nM). Antitumor agents.

1185763-69-2
DC9769 NVP-CGM097 (CGM-097) Featured

NVP-CGM097 (CGM-097) is a potent and selective MDM2 inhibitor.

1313363-54-0
DC22564 NVP-MELK8a hydrochloride Featured

NVP-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM.

2096992-20-8
DC7474 NVP-QAV-572

NVP-QAV-572 is a potent PI3K kianse inhibitor with IC50 of 10 nM.

957209-68-6
DC12583 NVR 3-778 Featured

NVR 3-778 (NVR3-778, NVR 3778) is a small molecule inhibitor of HBV replication that targets the viral core protein, a first-in-class capsid assembly modulator.

1445790-55-5
DC24111 NVS-CRF38

NVS-CRF38 is a potent, selective, orally bioavailable corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50 of 70 nM..

1207258-55-6
DC10473 NVS-PAK1-1 Featured

NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 µM in the Su86.86 cell line and MEK S289 phosphorylation with an IC50 = 0.21 in Su86.86 cells in which PAK2 is downregulated.

1783816-74-9
DC21431 NXL101

NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains.

904302-98-3
DC4237 NXY-059 (Cerovive)

NXY-059 (Cerovive) is an EGFR and HER2 autophosphorylation inhibitor, against purified EGFR and HER2 of 10.2 and 9.8 nM, respectively.

168021-79-2
DC12712 NY0116

NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays.

1003000-59-6
DC21432 NY-0123

NY-0123 is a novel potent Exchange proteins directly activated by cAMP (EPAC) antagonist with IC50 of 0.9 and 2.4 uM for EPAC1 and EPAC2, respectively.

1801911-70-5
DC12713 NY0128

NY0128 (NY 0128) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 29.99 uM for hNMUR1 and 10.30 uM for hNMUR2 in intracellular calcium mobilization assays.

1003000-60-9
DC21433 NY-0173

NY-0173 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 4.0 uM for EPAC1..

1801911-86-3
DC22185 O-1602

O-1602 (O1602) is an atypical cannabinoid, potent and selective agonist of GPR55 cannabinoid receptor with EC50 of 13 nM, shows no significant activity for CB1 and CB2 receptors (EC50>30 uM).

317321-41-8
DC8273 OAC2 Featured

OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts; an analog of OAC1.

6019-39-2
DC20481 OADS

OADS is a specific, reversible, small-molecule inhibitor directs against CLC (Chloride Channel) antiporter with Ki of 29 uM, has no specific effect on a CLC channel (ClC-1). .

5970-15-0
DC21435 OAT-1746

OAT-1746 is a novel potent, selective, orally active inhibitors of Arginase 1 and 2 (ARG1/2) with IC50 of <50 nM.

DC21436 OAT-177

OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1.

1799548-33-6
DC21437 OAT-2068 Featured

OAT-2068 is a potent, selective, orally bioavailable inhibitor of mouse chitotriosidase (mCHIT1) with IC50 of 29 nM, 143-fold selectivity over mAMCase.

2221950-65-6
DC25107 OBA-09

OBA-09 is a simple ester of pyruvate and salicylic acid, main metabolites of pyruvate and aspirin, respectively, exerts robust neuroprotective effect in the postischemic brain in vivo.

856095-68-6
DC23421 OBE022

OBE022 is a potent, highly selective, orally active antagonist of the contractile PGF2α prostaglandin receptor with Kb of 5.9 nM, shows no activity for other human PG receptors subtypes.

2005486-32-6
DC21438 OBP-801

OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM.

328548-11-4
DC1026 OC000459(Timapiprant) Featured

OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist.

851723-84-7
DC10144 Ochratoxin A(OTA) Featured

Ochratoxin A demonstrates nephrotoxicity and teratogenesis in animals, and shows inhibition of bacterial, yeast, and liver FARSL (phenylalanyl-tRNA synthetases) competitive with phenylalanine.

303-47-9
DC10145 Ochratoxin B(OTB) Featured

Ochratoxin B(OTB) is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion.

4825-86-9
DC5040 Oclacitinib maleate Featured

Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy.

1640292-55-2
DC9572 Octahydrocurcumin

Octahydrocurcumin is a hydrogenated derivatives of curcumin; metabolite of curcumin.

36062-07-4
DCAPI1338 (+,-)-Octopamine HCl

Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates.

770-05-8
DC20635 Odalasvir

Odalasvir (ACH-3102, JNJ-64289901) is a potent, second-generation HCV NS5A inhibitor in development for the treatment of hepatitis C..

1415119-52-6
DC12445 ODM-203 Featured

ODM-203 (ODM203) is a potent, selective, dual inhibitor of FGFR and VEGFR tyrosine kinases with approximately equal potency towards recombinant FGFR1, 2, 3 and 4, as well as VEGFR1, 2 and 3 (IC50=5-35 nM).

1430723-35-5
DC21643 ODQ

ODQ (sGC inhibitor ODQ) is a potent, selective, irreversible inhibitor of sGC (soluble guanylyl cyclase).

41443-28-1
DC12135 Officinalisinin I

Officinalisinin I is a steroidal saponin, isolated from Anemarrhena asphodeloides.

57944-18-0
DC12526 OGG1 inhibitor O8 Featured

OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM)..

350997-39-6
DC12452 OGT inhibitor 4a

OGT inhibitor 4a (OSMI-4 active form) is a novel potent, selective O-linked N-acetylglucosamine transferase (OGT) inhibitor with Kd of 8 nM, the active form of OSMI-4..

DC21439 OHM1

OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells.

1450995-09-1
DC20193 Olanexidine Hydrochloride semihydrate;OPB-2045, OPB-2045G

Olanexidine is a monobiguanide compound with bactericidal activity.

218282-71-4
DC12241 Oleamide

Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma.

301-02-0
DC8869 Oleuropein

Oleuropein is an antioxidant polyphenol isolated from olive leaf.

32619-42-4
DC23082 Oliceridine hydrochloride

Oliceridine hydrochloride (Olinvo, TRV130) is a potent, selective, and G protein biased μ opioid receptor (MOR) agonist with pEC50 of 8.1.

1401028-24-7
DC23372 Olinone Featured

Olinone is a selective inhibitor for the BET BRD1 with Kd of 3.4/3.7/8.6 uM for BRD4-BrD1/BRD3-BrD1/BRD2-BrD1, respectively, shows high selectivity over BET BRD2 (Kd>300 uM).

1770789-37-1
DCAPI1455 Olopatadine Hydrochloride

Olopatadine Hydrochloride

140462-76-6
DC10299 Olumacostat glasaretil

Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC).

1261491-89-7
DC10365 Omadacycline (tosylate) Featured

Omadacycline is novel, aminomethyl tetracycline antibiotic being developed for the treatment of community-acquired bacterial infections.

1075240-43-5
DC11335 Ombitasvir

Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).

1258226-87-7
DC10054 Ombrabulin hydrochloride Featured

Ombrabulin (AVE8062) hydrochloride is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors.

253426-24-3
DC5195 Omecamtiv mecarbil (CK-1827452) Featured

Omecamtivmecarbil (CK-1827452) is a specific cardiac myosinactivator and a clinical drug for left ventricular systolic heart failure.

873697-71-3
DC9077 Omeprazole

Omeprazole(Prilosec) is a proton pump inhibitor used in the treatment of dyspepsia.

73590-58-6
DC22463 ON 146040

ON 146040 is a potent, dual PI3K/BCR-ABL inhibitor with IC50 of 14/20 nM for PI3Kα/δ , IC50 of 20 nM for BCR/ABL.

1404231-34-0
DC12164 ON-013100 Featured

ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.

865783-95-5
DC22186 ON108110

ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM).

1415599-79-9
DC9927 ON1231320 Featured

ON1231320 is a potent selective inhibitor of Polo like kinase 2 (PLK2).

1312471-39-8
DC11417 ONC 212 Featured

ONC212, a fluorinated-ONC201 analogue, is a promising anti-cancer drug and also a selective agonist of GPR132.

1807861-48-8
DC8137 Oncrasin 1 Featured

Oncrasin 1 is a proapoptotic substance. Induces abnormal nuclear aggregation of PKCι and suppressing RNA transcription.

75629-57-1
DC23492 ONO-3080573

ONO-3080573 is a potent LPA1 inhibitor with IC50 of 11 nM..

1802079-40-8
DC23689 ONO-6126

ONO-6126 is a potent and selective PDE4 inhibitor for the treatment of bronchial asthma and allergic conjunctivitis..

401519-28-6
DC23490 ONO-9780307

ONO-9780307 is a potent LPA1 inhibitor with IC50 of 27 nM..

856691-44-6
DC23491 ONO-9910539

ONO-9910539 is a potent LPA1 inhibitor with IC50 of 22 nM..

1802079-45-3
DC22705 ONO-DI 004

ONO-DI 004 is a potent, selective EP1 agonist..

250605-97-1
DC10726 OPC 21268 Featured

OPC-21268 is a vasopressin 1 receptor antagonist potentially for the treatment of heart failure and hypertension.

131631-89-5
DC9404 Opicapone Featured

Opicapone(BIA 9-1067) is a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.

923287-50-7
DC10702 OR59402;NSC 48107 Featured

OR59402;NSC 48107 is a bioactive compound.

79606-45-4
DC20483 Org 42599 free base

Org 42599 is a cell-permeant, allosterically binding, small-molecule agonist of luteinizing hormone (LH) receptor that rescues the folding and cell surface expression mutant mutant human LH receptors A593P and S616Y (EC50=70.8 nM)..

501444-88-8
DC21446 Org 42599

Org 42599 is a cell-permeant, allosterically binding, small-molecule agonist of luteinizing hormone (LH) receptor that rescues the folding and cell surface expression mutant mutant human LH receptors A593P and S616Y (EC50=70.8 nM)..

501444-89-9
DC21447 Orita-13

Orita-13 is potent inhibitor of Migration inhibitory factor (MIF) tautomerase activity with Ki of 17 uM..

485-63-2
DC8343 Oritavancin Diphosphate(LY333328, Orbactiv)

Oritavancin is a lipoglycopeptide with bactericidal activity against gram-positive bacteria.

937-13-3
DC11365 Oritavancin (phosphate) Featured

Oritavancin is a semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria.

192564-14-0
DCAPI1397 Orlistat (Alli, Xenical) Featured

Orlistat is a drug designed to treat obesity. Orlistat's primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. Orlistat is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.

96829-58-2
DC23573 ORM-10962

ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, significantly reduces inward/outward NCX currents with IC50 of 55 and 67 nM, respectively.

763926-98-3
DCAPI1297 Orotic acid (6-Carboxyuracil)

Orotic acid (6-Carboxyuracil)

65-86-1
DC22407 Orvepitant

Orvepitant (GW823296) is a potent and selective, brain penetrant NK1 receptor antagonist with pKi of 10.2.

579475-18-6
DC23149 Oseltamivir acid

Oseltamivir acid (GS 4071, Ro 64-0802, Oseltamivir carboxylate) is a potent inhibitor of influenza neuraminidase (NA) with Ki of <1 nM for both A and B strains,showed potent activity against COVID-19(SARS-COV-2).

187227-45-8
DC8554 OSI-420 Featured

OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.

183320-51-6
DC9974 Isturisa (Osilodrostat) Featured

Osilodrostat is an inhibitor of aldosterone synthase and aromatase, for treating Cushing’s disease.

928134-65-0
DC11438 Osimertinib analogue Featured

Osimertinib analogue (C-005) is a potent EGFR inhibitor, which is 2-5 fold more selective than Osimertinib between above EGFR mutants and wild-type EGFR(A431) cells.

2050521-74-7
DC21449 OSMI-1 Featured

OSMI-1 is a cell-permeable, small molecule O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 uM.

1681056-61-0
DC12453 OSMI-4

OSMI-4 (OGT inhibitor 4b) is a novel potent, selective, cell-active O-linked N-acetylglucosamine transferase (OGT) inhibitor with EC50 of ~3 uM.

2260791-14-6
DC22304 ILK-IN-2 (CPD 22: OSU-T315 analog) Featured

ILK-IN-2 (OSU-T315 analog) is a ILK inhibitor.

1333146-24-9
DC21450 OSW-1 Featured

OSW-1 is a natural anti-enterovirus and anti-cancer compound that targets oxysterol-binding protein (OSBP) with Ki of 26 and 54 nM for OSBP and ORP4L, respectively.

145075-81-6
DC9501 Otilonium (bromide)

Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.

26095-59-0
DC12312 OTX008 (Calixarene 0118; PTX008) Featured

OTX008 is a selective inhibitor of galectin-1.

286936-40-1
DC7150 Birabresib (OTX015) Featured

OTX-015 is a new potent BRD2/3/4 inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors.

202590-98-5
DC22719 OUP-16

OUP-16 is a potent H4R agonist with a considerable selectivity over H3R..

1038917-11-1
DC23553 o-vanillin

o-vanillin (C29L.

148-53-8
DC21022 OX-14

OX-14 is a highly potent farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 2.46 nM, with significantly lower binding affinity to hydroxyapatite.

1219126-87-0
DC8676 Oxadiazon

Oxadiazon is a preemergent herbicide.

19666-30-9
DC10480 Oxamflatin Featured

Oxamflatin is a potent inhibitor of histone deacetylases (IC50 = 15.7 nM).

151720-43-3
DCAPI1236 Oxfendazole

Oxfendazole

53716-50-0
DCAPI1110 Oxibendazole

Oxibendazole

20559-55-1
DC8961 Potassium Oxonate

Oxonic acid potassium salt is an inhibitor of uricase, oxonic inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and inta

2207-75-2
DC10232 Oxybenzone

Oxybenzone is a benzophenone derivative used as a sunscreen agent.

131-57-7
DC9112 Oxybutynin HCl

Oxybutynin is also a possible treatment of hyperhidrosis (hyper-active sweating) .

1508-65-2
DC20489 Oxythiamine chloride hydrochloride

Oxythiamine chloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM.

614-05-1
DC12352 Oxythiamine (Hydroxythiamin)

Oxythiamine, an antimetabolite and a vitamin B1 antagonist, is a well-known thiamine antagonist and inhibitor of transketolase.

136-16-3
DCAPI1345 Ozagrel HCl

Ozagrel HCl

78712-43-3
DC9445 Ozagrel (sodium)

Ozagrel(OKY-046) sodium salt is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.

130952-46-4
DC7222 P005091(P5091) Featured

P005091(P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.

882257-11-6
DC5188 Sarecycline(P005672 hydrochloride) Featured

P005672 is a phase II drug for antibacterial/anti-inflammatory acne treatment.

1035979-44-2
DC11234 P053

P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6.

DC7221 P22077 Featured

P22077 is a potent inhibitor of ubiquitin-specific protease (USP) 7 (EC50=8.6 uM), P22077 also inhibits the closely related deubiquitinase (DUB) USP47.

1247819-59-5
DC20490 p32 inhibitor M36

p32 inhibitor M36 is a novel small molecule inhibitor of p32 mitochondrial protein, binds directly to p32 and inhibits p32 association with LyP-1.

802555-85-7
DC23112 p38 MAPK-IN-4

p38 MAPK-IN-4 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM for p38α, inhibits LPS-induced TNFα release in THP-1 cells with IC50 of 187 nM.

1006378-90-0
DC20001 p38α inhibitor 1

p38α inhibitor 1 is a p38α inhibitor extracted from patent WO 2008076265 A1.

1034189-82-6
DC10798 p38-α MAPK-IN-1 Featured

p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.

443913-15-3
DC21934 P516-0475

P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO (IC50=10 uM).

1359627-33-0
DC23317 P53R3

P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays.

922150-12-7
DC21520 P62-mediated mitophagy inducer

P62-mediated mitophagy inducer (PMI) is a small molecule P62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway.

1809031-84-2
DC7677 P7C3-A20 Featured

P7C3-A20 is an analogue of P7C3,a proneurogenic, neuroprotective agent.

1235481-90-9
DC22060 PAC1

PAC1 (Compound PAC1) is a novel PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation..

2158322-33-7
DC7477 pac-1 Featured

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first small molecule known to directly activate procaspase-3 to caspase-3.

315183-21-2
DC12200 PACAP (6-38), human, ovine, rat TFA

PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.

DC8638 Paclitaxel Featured

Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

33069-62-4
DC21408 Pactamycin

Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial act

23668-11-3
DC11113 Padsevonil

Padsevonil (UCB-0942, UCB0942) is a potential anti-seizure agent that functions as a pre- and post-synaptic inhibitor..

1294000-61-5
DC21454 P11 Featured

PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively.

942285-55-4
DC7659 Palifosfamide Featured

Palifosfamide is a novel molecule for the treatment of sof tissue sarcoma.

31645-39-3
DC10362 Palmitelaidic Acid

Palmitelaidic acid is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

10030-73-6
DC20491 Palmostatin B

Palmostatin B is a potent Acyl protein thioesterase 1 (APT1.

1233365-12-2
DC8459 Palovarotene(R 667) Featured

Palovarotene (R-667, RO-3300074) is a selective retinoic acid receptor gamma(RAR-γ) agonist for the treatment of emphysema.

410528-02-8
DCAPI1259 Pamidronate Disodium

Pamidronate Disodium

57248-88-1
DCAPI1175 Pamidronic acid

Pamidronic acid

40391-99-9
DC20769 Pamiparib Featured

Pamiparib (BGB-290, BGB290) is a highly potent, selective and brain penetrant PARP1/2 inhibitor with potent anti-tumor activity.

1446261-44-4
DC4107 Panadiplon (U-78875)

Panadiplon (U-78875) is an anxiolytic drug with a novel chemical structure that is not closely related to other drugs of this type.

124423-84-3
DC20492 Pandacostat

Pandacostat is the first nonselective HDAC inhibitor (pan-HDACi) with Ki of 0.12/0.07/0.95/0.18/0.032/1.1/0.5/1.4 uM for HDAC1/2/3/4/5/6/7/8/9, respectively.

1224158-00-2
DC12642 pan-PIM inhibitor 17

pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively.

1681021-52-2
DC12322 Papain

Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

9001-73-4
DC23618 PAPTP

PAPTP is a PAP-1 derivative, potent, specific Kv1.3 channel inhibitor with IC50 of 31 nM in Jurkat T lymphocytes by patch-clamp, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.

2176486-17-0
DC20234 PAQ Featured

PAQ (Compound 4c) is a quinoxaline derivative. PAQ is an orally active neuroprotective agent, which targets dopamine (DA) neurons and activates reticulum endoplasmic ryanodine receptor (RyR) channels, without effects on glia cells.

943902-10-1
DC10875 Paquinimod Featured

Paquinimod is a S100A9 inhibitor, which prevents S100A9 binding to TLR-4.

248282-01-1
DC9537 Paradol

Paradol(6-Paradol) is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects.

27113-22-0
DC10604 PARGYLINE HYDROCHLORIDE Featured

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO; Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively).

306-07-0
DC10893 Parimifasor Featured

Parimifasor is an immunomodulator, with anti-inflammatory activity.

1796641-10-5
DC21935 PARP10 inhibitor 22

PARP10 inhibitor 22 is a selective, cell-active inhibitor of PARP10 with IC50 of 1.8 uM, exhibits >10-fold selectivity over a large subset of other PARP family members.

DC12450 PARP11 inhibitor ITK7

PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs.

DC21104 PARP14 inhibitor H10

PARP14 inhibitor H10 (H10) is a potent, selective, cell-active PARP14 inhibitor with IC50 of 490 nM, with good selectivity over other PARPs (24-fold and 18-fold over PARP1 and TNKS1, respectively).

2084811-68-5
DC11445 Parthenolide Featured

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium).

20554-84-1
DC21456 PAT-1251

PAT-1251 (PAT 1251, PAT1251) is a potent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases.

2007885-39-2
DC22993 Pateamine A

Pateamine A (Pateamine) is a potent small molecule inhibitor of eukaryotic translation that stimulates eIF4AI/II and eIF4AIII activity, but not eIF4E, eIF2α, and elF4B.

139220-18-1
DC12184 Paullinic acid

Paullinic acid is a long-chain fatty acid that has been detected in multiple biofluids, such as blood and urine.

17735-94-3
DC9865 Paulownin Featured

Paulownin can highly inhibit the growth of H. pylori and exhibits strong inhibitory specificity against H. pylori related to E. coli.

13040-46-5
DC21457 Pax2 inhibitor EG1 Featured

Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM; inhibits Pax2 mediated expression with IC50 of 10 uM, and inhibits proliferation of Pax2 positive renal and ovarian cancer cell lines but has little effect on Pax2 negative cancer cells; inhibits embryonic kidney development.

693241-54-2
DC10157 PAβN dihydrochloride Featured

PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.

100929-99-5
DC22190 PBF509

PBF509 (PBF-509, NIR 178) is a novel selective and potent Adenosine A2A Receptor (A2AR) antagonist, antagonizes A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 and 8.2 nM, respectively.

DC7550 PBIT Featured

PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro.

2514-30-9
DC22191 PBT434 Featured

PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease; inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology; prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD.

1232841-78-9
DC21459 PC1244

PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM.

2046185-88-8
DC21460 PC945

PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.

1931946-73-4
DC23061 L-45

PCAF BRD inhibitor L-45 is a potent, selective, and cell-active PCAF bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4.

2079885-05-3
DC23651 PCARBTP

PCARBTP is a derivative, potent, specific Kv1.3 channel inhibitor, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.

2176486-23-8
DC8844 PCI-27483 Featured

PCI-27483 is a selective small molecule inhibitor of activated coagulation factor VII (FVIIa), which is in preclinical development as a novel anti-cancer agent.

871266-63-6
DC12080 PCI-33380

PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe).

1022899-36-0
DC23759 PCSK9 modulator 10

PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM.

1874254-18-8
DC23758 PCSK9-IN-7l

PCSK9-IN-7l is a potent, small molecule PCSK9 mRNA translation inhibitor with IC50 of 1.37 uM, shows limited bone marrow toxicity (IC50=27.1 uM)..

1632250-31-7
DC9744 PD0166285 Featured

PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.

185039-89-8
DC21466 PD166285 Featured

PD166285 (PD 0166285) is a broad-spectrum receptor tyrosine kinase (RTK) inhibitor that inhibits PDGFR-β, EGFR, and FGFR1 and c-Src with IC50 of 7-85 nM.

212391-63-4
DC12219 PD1-IN-2

PD1-IN-2 is a PD1 signaling pathway inhibitor, which acts as an immunomodulator.

1673534-97-8
DC21936 PD1-PD L1 inhibitor Polaris

PD1-PD L1 inhibitor Polaris is a novel potent, small molecule inhibitor of PD-1/PD-L1 interaction (IC50=0.1-10 nM in ELISA assays) with anti-cancer activity.

2201132-36-5
DC21467 PDD 00017273 Featured

PDD 00017273 is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM.

1945950-21-9
DC23693 PDE10A-IN-31

PDE10A-IN-31 is a potent, highly selective PDE10A inhibitor with IC50 of 2 nM for both rPDE10A and hPDE10A.

1639889-98-7
DC23701 PDE10A-IN-32

PDE10A-IN-32 is a potent, highly selective, brain penetrant PDE10A inhibitor with IC50 of 0.14 nM, displays no significant activity against other PDEs (IC50>1,000 nM)..

1338795-39-3
DC12555 PDE2 inhibitor 4

PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms.

2055160-19-3
DC23698 PDE4D-IN-26b

PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members.

1252807-76-3
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