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Cat. No. Product name CAS No.
DC21353 MSN-125

MSN-125 (MSN 125, MSN125) is a small molecule Bax inhibitor that inhibits Bax/Bak oligomerization and prevents mitochondrial outer membrane permeabilization (MOMP) with IC50 of 4 uM.

1592908-16-1
DC22167 MT-802 Featured

MT-802 (MT802) is a potent BTK PROTAC that induces degradation of both wild-type and C481S mutant BTK (DC50=9.1 nM).

2231744-29-7
DC20061 MtbHU-IN-1

MtbHU-IN-1 is an inhibitor of Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU), with a Kd of 98 nM for binding to WT MtbHU.

59736-84-4
DC22139 MTI-31 Featured

MTI31 (LXI-15029, mTOR inhibitor-31) is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G.

1567915-38-1
DC20230 mTOR inhibitor-1 Featured

mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.

468747-17-3
DC20468 Mtphagy Dye

Mtphagy Dye is a small-molecule fluorescent probe for visualizing mitophagy.

2137473-96-0
DC8240 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium Featured

MTS is water-soluble and used in the MTS assay.

138169-43-4
DC22168 MU1210

MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM (cellular BRET for CLK1).

DC22169 MU1300

MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly.

DC7205 Mubritinib (TAK 165) Featured

Mubritinib is a potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase.

366017-09-6
DC12212 Mulberrin (Kuwanon C)

Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM.

62949-79-5
DC23266 MUT-A

MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.

1591906-37-4
DC21924 mutant IDH1 inhibitor VVS

mutant IDH1 inhibitor VVS is a potent, selective mutant IDH1 inhibitor with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line..

1648909-73-2
DC20258 MW150 (MW01-18-150SRM)

MW150 (MW01-18-150SRM) is a selective, brain penetrant p38αMAPK, which is efficacious in diverse animal models of neurologic disorders.

DC21355 MW181

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.

1454658-87-7
DC21356 MW181 dihydrochloride

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.

1628503-08-1
DC21357 MW181 hydrochloride

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.

1454658-90-2
DC26051 MX1013 Featured

MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1

582316-00-5
DC22170 MX106

MX106 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 2.2 uM.

2170836-81-2
DC22171 MX107

MX107 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 3.1 uM.

2170102-50-6
DC21925 MY10

MY10 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation.

2204270-73-3
DC21926 MY33-3

MY33-3 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation.

2204280-41-9
DC9138 Mycophenolate Mofetil

Mycophenolate mofetil is a prodrug for mycophenolic acid, a potent inhibitor of inosine monophosphate dehydrogenase (IC50 = 11 nM). Inhibition of this enzyme blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes. In this way, mycop

128794-94-5
DCAPI1127 Mycophenolic (Mycophenolate)

Mycophenolic (Mycophenolate)

24280-93-1
DC21927 Myokinasib

Myokinasib is a mixed-type, selective inhibitor of Myosin Light Chain Kinase 1 (MLCK1) with IC50 of 7.9 uM, can bind to the free enzyme and the enzyme-substrate complex.

DC20469 myomiRs-IN-1

myomiRs-IN-1 is a small-molecule probe that selectively inhibits myogenic microRNAs (myomiRs) including miR-1, miR-133a, and miR-206.

1392224-59-7
DC21360 MZ1 Featured

MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.

1797406-69-9
DC22172 MZH29

MZH29 is a novel potent, selective, orally active type II FLT3 inhibitor with IC50 of 9 nM and 7 nM against FLT3-WT and FLT3-ITD, respectively.

2089590-80-5
DC8428 Lomitapide Mesylate

N-(2,2,2-trifluorethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate

202914-84-9
DC23254 N.41

N.41 (HIV inhibitor N.41, Vif inhibitor N.41) is a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G (A3G) protein (IC50=2.2 uM).

357441-99-7
DC8271 NSC-41589 Featured

N-[2-(methylsulfanyl) phenyl]acetamide.

6310-41-4
DC21107 N1-hexyl-N5-benzyl-biguanide mesylate

N1-hexyl-N5-benzyl-biguanide mesylate (HBB) is a potent and specific inhibitor of CYP3A4 AA epoxygenase activity with IC50 of 9.5 uM for inhibition of CYP3A4-mediated (±)-14,15-EET synthesis.

1834584-89-2
DC10359 N2-Methylguanine

N2-Methylguanine is a modified nucleoside. N2-Methylguanine is an endogenous methylated nucleoside found in human fluids.

10030-78-1
DC9543 N3PT

N3PT(N3-pyridyl thiamine) is a potent and selective transketolase(TK) inhibitor (IC50= 22 nM for Apo-TK) both in vitro and in vivo.

13860-66-7
DC10154 N6-(2-Phenylethyl)adenosine

N6-(2-Phenylethyl)adenosine is a selective A1 adenosine receptor agonist.

20125-39-7
DC23617 NAB-14 Featured

NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons.

1237541-73-9
DC8980 Nabumetone

Nabumetone(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.

42924-53-8
DC21358 N-acetyl lysyltyrosylcysteine amide Featured

N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation.

1287585-40-3
DC23924 N-Acetyl-Calicheamicin Featured

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic.

108212-76-6
DC20470 NAcM-COV

NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays.

2089293-81-0
DC20038 NAcM-OPT Featured

NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction.

2089293-61-6
DC21444 Nacubactam Featured

Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial.

2007923-17-1
DC9619 Nafamostat (mesylate) Featured

Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant,showed highly potent activity against COVID-19(SARS-COV-2).

82956-11-4
DC23132 Nalfurafine hydrochloride Featured

Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively).

152658-17-8
DC23102 Nalfurafine Featured

Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively).

152657-84-6
DCAPI1173 Nalidixic acid (NegGram)

Nalidixic acid (NegGram)

389-08-2
DC20016 Naloxegol Featured

Naloxegol is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation.

854601-70-0
DC8492 Naloxegol Oxalate(NKTR-118) Featured

Naloxegol is the first oral peripherally acting mu opioid receptor antagonists for opioid-induced constipation.

1354744-91-4
DC8407 Naloxone HCl Dihydrate Featured

Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose.

51481-60-8
DC20031 NAMPT inhibitor-linker 1

NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressin

2241019-57-6
DC20032 NAMPT inhibitor-linker 2

NAMPT inhibitor-linker 2 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressin

2241014-82-2
DC22632 NAN-190 hydrobromide

NAN-190 is a 5-HT1A receptor antagonist with Ki of 0.6 nM.

115338-32-4
DC10266 Nandrolone decanoate Featured

Nandrolone Decanoate is a mild form of an anabolic steroid.

360-70-3
DC10228 Nandrolone

Nandrolone is a synthetic, anabolic steroid analog of testosterone.

434-22-0
DCAPI1368 Naphyrone (O-2482)

Naphyrone (O-2482)

850352-53-3
DC22531 Naquotinib

Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).

1448232-80-1
DC22526 Naquotinib mesylate

Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).

1448237-05-5
DC20700 Naronapride

Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM.

860174-12-5
DC21361 N-aryl benzimidazole

N-aryl benzimidazole (NAB) is a small molecule that strongly and selectively protects diverse cell types from α-syn toxicity, promotes endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4 in wild-type yeast cells..

422554-26-5
DC23157 Naspm trihydrochloride Featured

Naspm is a selective antagonist of Ca2+-permeable AMPA receptors, blocks GluR2-lacking AMPARs, suppresses current responses induced by kainate in type II neurons with IC50 of 0.33 uM.

1049731-36-3
DCAPI1337 Natamycin(Pimaricin)

Natamycin(Pimaricin)

7681-93-8
DC9063 Nateglinide

Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).

105816-04-4
DCAPI1056 Nattokinase Featured

Nattokinase, Natto fermentation is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases.

133876-92-3
DC26021 6,8(2H,7H)-Isoquinolinedione,7-(acetyloxy)-5-chloro-3-(3,5-dimethyl-1,3-heptadienyl)-7-methyl- (9CI) Featured

Natural product derived from fungal source.

34695-81-3
DC20025 Nav1.7-IN-3

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.

1788872-06-9
DC11971 NAV-2729(Grassofermata) Featured

NAV 2729 (NAV2729) is a chemical potentiator for mRNA-LNPs, increasing the delivery efficiencies of mRNA-LNPs in vitro and in vivo. NAV 2729 (NAV2729) is a novel, direct and selective small molecule inhibitor of small GTPase ARF6 with IC50 of 1.5 uM in nucleotide exchange assays.

419547-11-8
DC20472 Naxillin Featured

Naxillin is the first non-auxin-like molecule that promotes root branching, activates a subset of auxin-induced transcripts, including AUX/IAA, SAUR and PIN families; induces auxin response in the basal meristem; represents a valuable tool to further decipher the molecular networks involved in lateral root branching.

301176-96-5
DC21362 NBC19

NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM..

2068818-75-5
DC7209 NBI42902

NBI-42902 is a potent inhibitor of peptide radioligand binding to the human GnRH receptor (K(i) = 0.56 nm).

352290-60-9
DC23638 NBQX disodium

NBQX disodium is the water soluble disodium salt of NBQX, which is a potent, selective and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.15 uM.

479347-86-9
DC21364 NC-001 Featured

NC-001 (NC 001, NC001, az-NC-001) is a potent, specific, cell-permeable inhibitor of immunoproteasome caspase-like sites (β1i and β1), does not correlate with inhibition of chymotrypsin-like sites..

1237540-68-9
DC21366 NC-043

NC-043 (15-Oxospiramilactone) is a diterpenoid derivative inhibitor of Wnt/β-catenin signaling that interferes with the β-catenin/TCF4 association.

1053172-87-4
DC22316 NCC007 Featured

NCC007 is a novel CKIα and CKIδ dual inhibitor. NCC007 that showed stronger period effects (0.32 μM for 5 h period lengthening) in a cellbased circadian assay.

DC23377 NCD-25

NCD-25 is a novel potent, selective LSD1 inhibitor with IC50 of 0.48 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO..

1456972-46-5
DC23353 NCD-38

NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO (IC50>100 uM).

2078047-42-2
DC21369 NCGC 00067819 Featured

NCGC 00067819 is a small molecule compound that potentiates CREB signaling with EC50 of 16 nM in the primary screen and 79 nM in the CHO CRE-β-lactamase confirmation assay.

847163-23-9
DC23699 NCGC00071837

NCGC00071837 (PDE4-IN-5A) is a potent, selective PDE4 inhibitor with IC50 of 24 and 18 nM for PDE4A and PDE4D, respectively, weak inhibition for PDE4B (IC50=0.54 uM) and inactive for PDE1/3/5/7/9/10/11.

578747-98-5
DC21372 NCGC00185684

NCGC00185684 (ML154) is a potent, selective, brain penetrant NPSR (Neuropeptide S receptor.

1345964-89-7
DC10476 NCGC00244536 Featured

NCGC00244536 is a potent KDM4A inhibitor with an IC50 of 10 nM.

2003260-55-5
DC23741 NCT-502

NCT-502 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3.7 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.

1542213-00-2
DC20004 NCT-506 Featured

NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM.

2231098-99-8
DC21387 NCX-4016

NCX-4016 (Nitroaspirin.

175033-36-0
DC9810 ND-646 Featured

ND-646(ND646) is a small-molecule allosteric inhibitor of acetyl-CoA carboxylase (ACC).

1434639-57-2
DC23681 ND-654 (ND654)

ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively.

1434641-55-0
DC10302 N-deacetylated BMS-202

N-deacetylated BMS-202 is the deacetylated of BMS-202. BMS-202 is an inhibitor of the PD-l/PD-Ll interaction, mainly used for cancer treatment.

2310135-18-1
DC10438 N-Desmethylclozapine Featured

N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor.

6104-71-8
DC21374 NDT 9513727

NDT 9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay.

439571-48-9
DC12348 NE 10790 (3-PEHPC) Featured

NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

152831-36-2
DC12511 Nebicapone

Nebicapone (BIA 3-202, BIA3-202) is a potent, long-acting, reversible and competitive peripheral inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 3.7 nM for rat brain COMT, much less potent for liver COMT with IC50 of 696 nM.

274925-86-9
DC10551 Necrostatin 2 racemate Featured

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

852391-15-2
DC2084 Necrostatin-1 Featured

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.

4311-88-0
DC23292 Necrox-5 methanesulfonate Featured

NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.

1383718-29-3
DC21375 NecroX-2 Featured

NecroX-2 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI.

1120333-38-1
DCAPI1393 Nedaplatin (Aqupla) Featured

Nedaplatin (Aqupla) is a derivative of cisplatin for inhibition of tumor colony forming units with IC50 of 28.5 μg/mL.

95734-82-0
DC20473 NEDD8 inhibitor M22 Featured

NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.

864420-54-2
DC9569 Nefazodone (hydrochloride) Featured

Nefazodone hydrochloride is an antidepressant drug.

82752-99-6
DC23246 Nef-IN-B9

Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM.

1473404-51-1
DCAPI1513 Nefopan hydrochloride

Nefopanhydrochloride

23327-57-3
DC8194 PP3 Featured

Negative control for the Src kinase inhibitor PP2.

5334-30-5
DC8290 (S)-PFI-2 HCl Featured

Negative control of (R)-PFI 2 hydrochloride. Exhibits 500-fold lower activity in a SETD7 enzymatic assay (IC50 = 1 μM) compared to the active enantiomer.

1627607-88-8
DC12465 NEK6 inhibitor 8 Featured

NEK6 inhibitor 8(ZINC05007751) is a novel inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 uM, compound 8 is very selective against NEK1 and NEK6, while no signifcant activity was observed against NEK2, NEK7, and NEK9.

591239-68-8
DC20743 Neladenoson dalanate

Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure..

1239309-58-0
DC20744 Neladenoson dalanate hydrochloride

Neladenoson dalanate is a potent, selective, orally acitve partial adenosine A1 receptor (A1AR) agonist (EC50=0.1 nM) for the treatment of chronic heart failure..

1239235-25-6
DC4129 Arranon Featured

Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.

121032-29-9
DC22175 NEO214

NEO214 (NEO-214) is a novel, BBB-permeable rolipram-perillyl alcohol conjugate, shows effectivity against both TMZ-sensitive and TMZ-resistant glioma cells (T98G IC50=40 uM).

1361198-80-2
DC23087 Neoandrographolide Featured

Neoandrographolide has antiradical, anti-inflammatory,and hypolipidemic effects, it protects the cardiovascular without significant liver damage. Neoandrographolide as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIA

27215-14-1
DC23057 Nestorone

Nestoron2 (ST1435, Elcometrine) is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive, a high-affinity agonist of the progesterone receptor..

7759-35-5
DC22636 Netarsudil dihydrochloride Featured

Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.

1253952-02-1
DC9353 Netilmicin (sulfate)

Netilmicin Sulfate is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin.

56391-57-2
DC8100 Netupitant

Netupitant is a highly potent and selective, orally active neurokinin-1 receptor antagonist with Ki of 0.95 nM.

290297-26-6
DC23275 NEU-1953(NEU1953)

NEU-1953 (NEU1953) is a potent inhibitor of P. falciparum with EC50 of 0.43 uM (T. brucei), demonstrates improved ADME profile over the NEU-961..

2218480-85-2
DC5131 Neuropathiazol Featured

Neuropathiazol selectively induces neuronal differentiation of primary hippocampal neural progenitor cells. It is more potent and selective compared to retinoic acid. Also suppresses astrocyte differentiation.

880090-88-0
DC12238 Neurotoxin Inhibitor

Neurotoxin Inhibitor is a neurotoxin inhibitor.

951571-70-3
DC23016 Nexinhib 20

Nexinhib 20 is a novel small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors.

1162656-24-7
DC12660 NFAT Inhibitor-1 Featured

NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.

249537-73-3
DC12176 NFAT Transcription Factor Regulator Featured

NFAT Transcription Factor Regulator is an IL-2 synthesis inhibitor with an IC50 of 182 nM.

245747-71-1
DC23081 NFPS

NFPS (ALX-5407) is a potent, selective GlyT1 inhibitor with IC50 of 2.8 and 9.8 nM for hGlyT1 and rGlyT1 respectively, >5,000-fold selectivity over rGlyT2.

405225-21-0
DC8076 NG 52 (Compound 52 ) Featured

NG 52 (Compound 52) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).

212779-48-1
DC21380 NGD-4715

NGD-4715 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1), has anxiolytic, antidepressant and anorectic effects..

476322-70-0
DC11281 NGI-1 (ML414) Featured

NGI-1 (ML414) is a potent, cell-permeable oligosaccharyltransferase (OST) inhibitor with IC50 of 1.1 uM.

790702-57-7
DC11200 NGI-1 derivative C-19

NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A.

924471-88-5
DC8525 NIBR-17 Featured

NIBR-17 is a pan class I PI3K inhibitor with IC50 values of 1, 9.2, 9 and 20 nM respectively for PI3Kapha - delta.

944396-88-7
DC21742 NIBR-3049

NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively..

1260181-14-3
DC7977 Nicaraven Featured

Nicaraven is an antivasospastic substance.

79455-30-4
DC25090 Nicardipine

Nicardipine(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage..

55985-32-5
DC9068 Niclosamide

Niclosamide(BAY2353) is used for the treatment of most tapeworm infections by inhibiting DNA replication.

50-65-7
DC21243 Nidufexor(LMB-763) Featured

Nidufexor (LMB763, LMB-763) is a novel potent farnesoid X receptor (FXR) agonist for the treatment of non-alcoholic steatohepatitis (NASH) and hepatobiliary disorders.

1773489-72-7
DC9079 Nifedipine

Nifedipine(Adalat), a potent vasodilator agent with calcium antagonistic action.

21829-25-4
DCAPI1571 Nifuratel

Nifuratel

4936-47-4
DC12297 Nigakinone

Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu.

18110-86-6
DC10028 NIH-12848 Featured

NIH-12848 (NCGC00012848-02) is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, was explored as a tool for investigating this enigmatic, low activity,

959551-10-1
DC4192 Nilutamide

Nilutamide is an antiandrogen medication used in the treatment of advanced stage prostate cancer.

63612-50-0
DC9379 Nilvadipine

Nilvadipine(FR34235) is a calcium channel blocker for treatment of hypertension.

75530-68-6
DC9052 Nimesulide

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

51803-78-2
DC7758 Nimorazole Featured

Nimorazole is a nitroimidazole anti-infective.

6506-37-2
DCAPI1251 Nitazoxanide (Alinia, Annita) Featured

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM).

55981-09-4
DC21383 NITD-304

NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv.

1473450-60-0
DC21384 NITD-349

NITD-349 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 23 nM against M tuberculosis H37Rv.

1473450-62-2
DC21385 NITD-564

NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.

1614262-75-7
DC21386 NITD-916

NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb.

1614262-83-7
DC9561 Nitisinone Featured

Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.

104206-65-7
DC9085 Nitrendipine

Nitrendipine is a calcium channel blocker with marked vasodilator action.

39562-70-4
DC21388 NJK14047

NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation.

1800576-41-3
DC20916 NKH 477 hydrochloride Featured

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase.

138605-00-2
DC9786 NKP-1339 Featured

NKP-1339 is the first-in-class ruthenium-based anticancer drug in clinical development against solid cancer and has recently been studied successfully in a phase I clinical trial.

197723-00-5
DC5172 NLG919(GDC-0919) Featured

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.

1402836-58-1
DC26132 NLRP3 Inflammasome Inhibitor I

NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.

16673-34-0
DC22177 NLY01

NLY01 (NLY-01, GLP1R agonist NLY01) is a potent, brain-penetrant long-acting GLP1R agonist, protects against the loss of dopaminergic neurons and behavioral deficits in the α-synuclein preformed fibril (α-syn PFF) mouse model of sporadic Parkinson's disea

DC11134 NMac1

NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM.

1332290-68-2
DC20105 NMDAR antagonist 1 Featured

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist.

2220162-06-9
DC8829 Betahistine EP Impurity C(NSC19005) Featured

N-Methyl-N,N-bis(2-pyridylethyl)amine is used as a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes.

5452-87-9
DC7212 NMS-873 Featured

NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP).

1418013-75-8
DC21390 NMS-P293

NMS-P293 is a novel potent and selective PARP-1 inhibitor possessing >200-fold selectivity versus PARP-2.

DC23556 NMS-P645

NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.

1482518-95-5
DC8445 NMS-P937 (NMS1286937) Featured

NMS-P937 (NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Phase 1.

1034616-18-6
DC21224 NMT1 inhibitor B13

NMT1 inhibitor B13 (LCL4) is a myristoylCoA analog that acts as a small molecule inhibitor of NMT1 with IC50 of 77.6 uM, blocks Src myristoylation and Src localization to the cytoplasmic membrane.

35922-06-6
DC21391 NNC 05-2090 hydrochloride Featured

NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM.

184845-18-9
DC22893 NNC-0640

NNC-0640 (NNC 0640, NNC0640) is a potent, selective glucagon receptor (GCGR) negative allosteric modulator with IC50 of 69.2 nM.

307986-98-7
DC21392 NNC-711 Featured

NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM.

145645-62-1
DC4204 Nocodazole Featured

Nocodazole inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. Enhances homology-directed repair (HDR) efficiency 9 to 31% (depending on cell cycle phase) and increases Cas9-mediated gene editing frequencies.

31430-18-9
DC4111 Nolatrexed (AG-337) Featured

Nolatrexed (AG-337), inhibits purified recombinant human thymidylate synthase (TS) with a Ki of 11 nM, and displays non-competitive inhibition kinetics. It was further shown to inhibit cell growth in a panel of cell lines of murine and human origin, displ

152946-68-4
DC10549 Nomifensine maleate Featured

Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.

32795-47-4
DC9342 Noopept

Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.

157115-85-0
DCAPI1558 Oxiracetam

Nootropic agent shown to exhibit learning and memory improvement and cognitive function impairment prevention. Mechanism of action has not been quantified, but current theories suggest a modulation of glutamatergic and cholinergic neurotransmissions with

62613-82-5
DC8848 Nosiheptide

Nosiheptide is a bicyclic thiopeptide antibiotic produced by several species of actinomycetes, notably Streptomyces.

56377-79-8
DC26002 TOPK inhibitor-1 Featured

Novel PDZ binding kinase (PBK) inhibitor.

1338540-81-0
DC26003 (R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxythieno[2,3-c]quinolin-4(5H)-one Hydrochloride Featured

Novel PDZ binding kinase (PBK) inhibitor.

1338545-01-9
DC10453 NP-118809 Featured

NP-118809 is a N-type calcium channel blocker.

41332-24-5
DC11212 NP161

NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM.

1421763-05-4
DC22179 NPD13668

NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.

864819-54-5
DC22180 NPD8733 Featured

NPD8733 (NPD-8733) is a small-molecule ligand of valosin-containing protein (VCP)/p97, binds to the D1 domain of VCP/p97.

696655-62-6
DC8398 NPS-1034 Featured

NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.

1221713-92-3
DC21928 NPT 200-​11 Featured

NPT200-11 is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor.

2227057-23-8
DC21397 AI-1

Nrf2 acticatior AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM.

75483-04-4
DC21398 AI-2

Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1.

1380107-92-5
DC20477 Nrf2 activator 16

Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively.

321694-20-6
DC21399 AEM1 Featured

NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC).

1030123-90-0
DC20251 NRX-103094 Featured

NRX-103094 is an enhancer of an E3 ligase-substrate interaction.

2763260-36-0
DC20254 NRX-103095 Featured

NRX-103095 is an enhancer of an E3 ligase-substrate interaction.

DC20248 NRX-1532 Featured

NRX-1532 is an enhancer of an E3 ligase-substrate interaction.

DC20249 NRX-1933 Featured

NRX-1933 is an enhancer of an E3 ligase-substrate interaction.

2763260-30-4
DC20252 NRX-252114 Featured

NRX-252114 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-252114 induces mutant β-catenin degradation.

2763260-39-3
DC20253 NRX-252262 Featured

NRX-252262 is an enhancer of an E3 ligase-substrate interaction.

2438637-61-5
DC20250 NRX2663 Featured

NRX-2663 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-2663 enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 µM and a Kd of 54.8 nM[1].

2763260-34-8
DC8783 NS 9283 Featured

NS 9283 is a positive allosteric modulator of α4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without effecting the maximum efficacy (HEK293-hα4β2 cells).

913830-15-6
DC23137 NS-018

NS-018 (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).

1239358-86-1
DC23130 NS-018 hydrochloride

NS-018 hydrochloride (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).

1239358-85-0
DC23131 NS-018 maleate Featured

NS-018 maleate (NS018, Ilginatinib) is a potent and highly selective JAK2 inhibitor (IC50=0.72 nM).

1354799-87-3
DC22181 NS-062

NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR.

2226257-92-5
DC20479 NS-3-008 hydrochloride

NS-3-008 hydrochloride is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM.

1025276-65-6
DC20478 NS-3-008 HCl Featured

NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM.

1172854-54-4
DC9608 NS-304(Selexipag) Featured

NS-304(Selexipag; ACT-293987) is an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension.

475086-01-2
DC23798 NSC 145366

NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM.

1052515-37-3
DC11313 NSC 146109 (hydrochloride) Featured

NSC 146109 is an activator of the tumor suppressor p53 that increases expression of p53 and the p53 target DR5 in wild-type and p53-knockout HCT116 colon adenocarcinoma cells.

59474-01-0
DC12509 NSC 146268

NSC 146268 (NSC146268, 6-Aza-2-thiouridine) is a novel small molecule inhibitor of CD151, inhibits proliferation of metastatic triple negative breast cancer cell lines (MDA-MB 231 and MDA-MB 468, IC50 of 6.0 and 6.2 ug/mL).

1191421-14-3
DC20918 NSC 15765

NSC 15765 (Compound C5, DNA2 inhibitor C5) is an effective, selective and competitive inhibitor of DNA2 nuclease with IC50 of 20 uM.

35973-25-2
DC10695 NSC 191412 Featured

NSC 191412 is a bioactive compound.

370-16-1
DC21277 NSC 19630

NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.

72835-26-8
DC23598 NSC 23925

NSC 23925 is a small molecule compound that reverses multiple drug resistance (MDR) in human cancer cell lines, reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR.

858474-14-3
DC23572 NSC 23925B

NSC 23925B is a small molecule agent that reverses MDR in cancer cells, reverses MDR in several drug-resistant cell lines expressing Pgp.

1369591-04-7
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