| DC36301 |
BTD |
BTD is a selective TRPC5 activator with selectivity for TRPC5 over other TRP channels. BTD also activates TRPC1:5 and TRPC4:5 heteromers. |
|
| DC36302 |
PDD-00017272 |
PDD-00017272 is a potent poly (ADP ribose) glycohydrolase (PARG) inhibitor. |
|
| DC36303 |
4-Thiouridine |
4-Thiouridine, also known as 4-SU, is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities. |
|
| DC36304 |
Thalidomide-linker 11 |
Thalidomide-PEG3-ethylamine is a functionalized cereblon ligand for PROTAC research and development. Thalidomide-PEG3-ethylamine incorporates an E3 ligase ligand plus a short PEG linker ready for conjugation to a target protein ligand. |
|
| DC36305 |
aTAG 2139
Featured
|
aTAG 2139 (CFT-2139) is an aTAG-based MTH1 fusion protein degrader with a DC50 value of 1.1 nM. aTAG 2139 has a Ki value of 2.1 nM for MTH1. |
|
| DC36306 |
LDV |
LDV is an α4β1 integrin (VLA-4) ligand and non-fluorescent derivative of LDV FITC. |
|
| DC36307 |
J-2156 |
J-2156 is a high affinity human somatostatin receptor 4 (sst4) agonist that reduces inflammatory airway hyperresponsiveness in acute and chronic airway inflammation. J-2156 also exhibits anxiolytic effects. |
|
| DC36308 |
L-Buthionine sulfoximine |
L-Buthionine sulfoximine is an irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor that depletes glutathione levels by inhibiting synthesis. L-Buthionine sulfoximine also induces ferroptosis in vitro. |
|
| DC36310 |
VH032 phenol - linker 2 |
VH032 phenol - linker 2 is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. It incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. |
|
| DC36311 |
cis VH 032 |
cis VH 032, amine dihydrochloride is a negative control for the functionalized VHL ligand VH 032, amine. |
|
| DC36312 |
Reparixin L-lysine salt |
Reparixin L-lysine salt is a potent and noncompetitive CXCR1 and CXCR2 allosteric antagonist that inhibits migration of neutrophils induced by CXCL1, CXCL2, CXCL8 and CINC-1. This product also inhibits vascular permeability and neutrophil recruitment in in vivo models of mild and severe ischemia/reperfusion injury. Also selectively depletes cancer stem cells in human breast cancer cell lines and xenograft models. |
|
| DC36313 |
AM-12 |
AM-12 is a TRPC5 inhibitor and Galangin derivative that inhibits effects of TRPC5 activator (-)-Englerin A but potentiates effects of physiological activators Sphingosine-1-phosphate and LPC. |
|
| DC36314 |
Urapidil HCl |
Urapidil HCl is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. Urapidil HCl inhibits cAMP accumulation induced by forskolin. It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol. Urapidil HCl lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine. |
|
| DC36315 |
N-Dipropyldopamine hydrobromide |
N,N-Dipropyldopamine HBr is a dopamine receptor agonist. It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum as well as reduces homovanillic acid (HVA) levels. N,N-Dipropyldopamine reduces spontaneous locomotor activity in mice, an effect that can be reversed by the antipsychotic spiroperidol. |
|
| DC36316 |
Histamine trifluromethyl toluidine |
HTMT is a histamine H1 receptor agonist that binds to the histamine H4 receptor but does not increase calcium mobilization. HTMT increases intracellular calcium and inositol phosphate levels as well as proliferation of cholangiocytes. |
|
| DC36317 |
Obafluorin |
Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens. It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris. |
|
| DC36318 |
NSC-207895 |
NSC-207895 is an inhibitor of the p53-binding protein MDMX. NSC 207895 decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21). It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines selectively over wild-type and p53-null osteosarcoma cells |
|
| DC36319 |
D-Ala-3-(2-naphthalenyl)-D-Ala-L-Ala-L-Trp-D-Phe-L-lysinamide TFA |
GHRP-2 TFA is an orally bioavailable synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It induces GH release from pituitary cells and binds to hypothalamic membranes. GHRP-2 TFA also increases food intake and weight gain. |
|
| DC36321 |
3-amino-6-Isocyanoacridine |
ICAAc is a solvatochromic fluorescent pH probe. As the polarity of the solvent increases, the emission wavelength of ICAAc increases. It displays excitation/emission maxima of 466/553, 431/515, and 418/503 nm in water, dioxane, and hexane, respectively. The absorption maximum of ICAAc decreases with increasing pH. It displays absorption/emission maxima of 470/554 and 428/553 nm at pH 3 and 11, respectively, in aqueous Britton-Robinson buffer, and the fluorescence intensity increases as pH decreases. ICAAc can be used for live cell applications. |
|
| DC36322 |
(+)-Phomalactone |
Phomalactone is a fungal metabolite that is active against various strains of plant pathogenic fungi. |
|
| DC36323 |
BMDB HCl |
BMDB HCl is an analytical reference standard intended for research and forensic applications. |
|
| DC36324 |
Chlamydocin |
Chlamydocin is a histone deacetylase (HDAC) inhibitor with anticancer properties. Chlamydocin increases acetylation of histone H3 and histone H4 and inhibits growth of A2780, Malme-3M, MCF-7, HT-29, and HeLa cancer cells. Chlamydocin also increases lifespan by 10% in a P185 mouse allograft model. |
|
| DC36325 |
Acetylcimigenol arabinoside |
Acetylcimigenol arabinoside is a triterpene glycoside originally isolated from Cimicifuga. |
|
| DC36326 |
Rebaudioside D |
Rebaudioside D is a natural non-caloric sweetener. It is a steviol glycoside metabolized by gut microbiota to steviol, a compound whose safety is widely studied. |
|
| DC36327 |
EATC |
EATC is a degradation product of the antibiotic tetracycline. It is active against Pseudomonas, Agrobacterium, Moraxella, Bacillus, and E. coli. |
|
| DC36328 |
CAY10737 |
CAY10737 is a turn-on fluorescent probe for the detection of carbon monoxide (CO). It is selective for CO over a variety of anions, amino acids, amines, biothiols, and reactive species. In the presence of palladium (Pd) and CO, CAY10737 undergoes the Pd0-mediated Tsuji-Trost reaction to release a fluorescent compound that has absorption and emission maxima of 678/714 nm, respectively. This fluorescence can be used to detect CO production in vitro and in vivo. |
|
| DC36329 |
TFLLR-NH2 TFA |
TFLLR-NH2 TFA is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that induces calcium mobilization in dorsal root ganglion neurons. In vivo, TFLLR-NH2 stimulates plasma extravasation in the bladder, esophagus, stomach, intestine, and pancreas in wild-type, but not PAR1-/-, mice. It also reduces carrageenan-induced hyperalgesia in rats. |
|
| DC36330 |
NSC 33700 |
γ-Valerolactone is a prodrug form of γ-hydroxyvaleric acid. |
|
| DC36331 |
Siquil |
Triflupromazine is a phenothiazine that binds to muscarinic receptors and inhibits serotonin (5-HT) uptake by synaptosomes. Formulations containing triflupromazine were previously used as antipsychotics. |
|
| DC36332 |
MEGX HCl |
Norlidocaine is an active metabolite of lidocaine formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration reduces thrombus formation in microvascular injury. Plasma levels of Norlidocaine following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis. |
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