| DC36333 |
Photoswitchable PAD inhibitor |
Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro. It does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination. |
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| DC36334 |
4-methyl GHB |
GHV sodium salt is a sedative and active metabolite of γ-valerolactone. |
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| DC36335 |
L-Moses HCl |
L-Moses HCl is an inhibitor of the p300/CBP-associated factor (PCAF) bromodomain. It displaces the PCAF bromodomain from histone H3.3 in a nanoBRET target engagement assay when used at a concentration of 5 μM. |
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| DC36336 |
9(S)-Erythromycylamine |
Erythromycylamine is a macrolide antibiotic and an active metabolite of dirithromycin. It is active against a variety of bacteria, including strains of S. pyogenes, S. pneumoniae, L. monocytogenes, and B. pertussis. It is also active against 28 clinical isolates of M. avium complex (MAC) isolated from patients with AIDS. Erythromycylamine inhibits polylysine and polyproline synthesis in a cell-free assay. |
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| DC36337 |
Antibiotic XK-62-2 sulfate |
Micronomicin sulfate is an aminoglycoside antibiotic originally isolated from Micromonospora. It is active against S. aureus, B. subtilis, B. cereus, E. coli, and K. pneumoniae. |
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| DC36338 |
Biotinyl tyramide |
Biotinyl tyramide is a reagent used for tyramide signal amplification (TSA) via catalyzed reporter deposition (CARD). In CARD, a reporter enzyme, such as horseradish peroxidase (HRP) conjugated to a secondary antibody, is bound to the target of interest and catalyzes the covalent deposition of biotinyl tyramide to the sample. The sample is then probed by a detector, such as streptavidin-HRP, allowing detection via chromogenic or fluorescent methods. Biotinyl tyramide has been used in immunohistochemistry, ELISA, Western blot, and in situ hybridization applications. |
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| DC36339 |
Dansyl chloride |
Dansyl chloride is a reactive probe for the derivatization of primary amines, including those on amino acids, peptides, and polyamines, for detection by HPLC. It has also been used for the derivatization of compounds containing phenol groups, such as steroids, for detection by MS/MS. Dansyl chloride is a fluorescent probe for proteins and enzymes. It displays excitation/emission maxima of 340/535 nm, respectively, in acetone. |
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| DC36340 |
BMY 29304 |
Siamycin I is a tricyclic peptide with antiviral and antibacterial activities. It is active against HIV-1 and CBL-20 strain of HIV-2. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells. It is also active against B. subtilis, M. luteus, and S. aureus. Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP). |
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| DC36341 |
(Z)-Entacapone |
cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone. It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure. |
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| DC36342 |
Boromycin |
Boromycin is a boron-containing macrolide antibiotic that inhibits growth of B. subtilis and induces efflux of potassium ions from B. subtilis without affecting Na+/K±ATPase activity. It decreases the synthesis of protein, RNA, and DNA in B. subtilis, inhibits the growth of B. halodurans, and inhibits the futalosine pathway of menaquinone synthesis in B. halodurans. Boromycin reverses bleomycin-induced cell cycle arrest at the G2 phase in Jurkat cells. It inhibits replication of the HIV-1 strains LAV-1 and RF and the HIV-2 strain LAV-2 in MT-4 cells. It also inhibits replication of a clinical isolate of HIV-1, strain KK-1, in MT-4 cells and peripheral blood mononuclear cells. |
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| DC36343 |
Lariatin A |
Lariatin A is an antimycobacterial lasso peptide active against M. tuberculosis and M. smegmatis. Lariatin A increases survival in a silkworm model of M. smegmatis infection. |
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| DC36344 |
Desacetyl cefapirin |
Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin. Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus. |
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| DC36345 |
Ganefromycin α |
Phenelfamycin E is an antibiotic active against β-hemolytic Streptoccus, S. pneumoniae, C. difficile, C. perfringens, and P. magnus Gram-positive bacteria. Phenelfamycin E increases survival in a mouse model of lethal S. pyogenes infection in a dose-dependent manner. Dietary administration of phenelfamycin E increases body weight in chickens. |
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| DC36346 |
NSC 379527 |
GHK is a peptide released during extracellular matrix (ECM) protein degradation following tissue injury. It binds to copper to form GHK-Cu, a complex with diverse biological activities, including roles in tissue remodeling and wound healing, hair growth, and suppression of inflammation. GHK increases keratinocyte proliferation in vitro, as well as the number of cells positive for the keratinocyte stem cell marker p63 and the protein levels of integrin α6 and β1 in a skin equivalent model. It also reduces infiltration of inflammatory cells and decreases TNF-α and IL-6 protein levels in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary fibrosis induced by bleomycin. |
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| DC36347 |
Oleoyl-D-lysine sodium |
Oleoyl-D-lysine sodium is an inhibitor of glycine transporter 2a (GlyT2a). It selectively inhibits GlyT2a over GlyT1b and reduces allodynia in a nerve ligation rat model of neuropathic pain. |
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| DC36348 |
C16-GHK |
Pal-GHK is a form of the extracellular matrix-derived peptide GHK containing palmitic acid, which allows it to penetrate the stratum corneum to the epidermal and dermal skin layers. Pal-GHK increases collagen synthesis in skin fibroblasts. It has been used with the zwitterionic surfactant C12 dodecyldimethylamine oxide (C12DMAO) to study self-assembly of the mixture into aggregates, ribbons, and nanobelts. Pal-GHK has also been used as an internal standard for the quantification of pal-KTTKS in anti-wrinkle creams by LC-MS/MS. |
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| DC36349 |
Desertomycin A |
Desertomycin A is fungal metabolite and the major component of the desertomycin antibiotic complex. |
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| DC36350 |
Spinacene |
Squalene is a biosynthetic precursor to all steroids. An oil-in-water emulsion of squalene synergistically increases adaptive immune responses to glucopyranosyl lipid adjuvant (GLA), a toll-like receptor 4 (TLR4) agonist, compared with an aqueous formulation of GLA. Formulations containing squalene have been used as adjuvants in vaccines and as hair and skin conditioning agents. |
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| DC36351 |
(E)-Feruloyltyramine |
Alfrutamide is a phenolic amide that has diverse biological activities including anti-inflammatory, antioxidative, and antiproliferative properties. It decreases nitric oxide (NO) production and inducible NO synthase (iNOS) activity and increases NO scavenging without inducing cytotoxicity. It also scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in TLC autographic and spectrophotometric assays. |
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| DC36352 |
Feglymycin |
Feglymycin is a 13-amino acid peptide that has antibacterial and antiviral activities. It is active against Gram-positive bacteria and inhibits HIV viral replication. |
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| DC36353 |
Imidocarb propionate |
Imidocarb propionate is an antiprotozoal agent that eliminates blood parasites. Formulations containing imidocarb have been used in the veterinary treatment of babesiosis and other protozoal infections. |
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| DC36354 |
PBD-BODIPY |
PBD-BODIPY is a probe for the spectrophotometric measurement of autoxidation reactions. Co-autoxidation of the PBD-BODIPY signal carrier and a hydrocarbon co-substrate can be quantified by monitoring loss of absorbance at 591 nm. |
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| DC36355 |
Roridin L2 |
Roridin L2 is a fungal metabolite. |
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| DC36357 |
Eriodictyol 7-O-neohesperidoside |
Neoeriocitrin is a flavonoid that has antioxidative and osteogenic activities. It inhibits the production of DPPH radicals and the formation of superoxide radicals. Neoeriocitrin increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059. It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin. |
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| DC36358 |
Glycylpressin |
Terlipressin is a prodrug form of lysipressin and a partial agonist of the vasopressin V1A receptor. It is also an agonist of vasopressin V1B and V2 receptors. Terlipressin in combination with norepinephrine improves vascular reactivity and mean arterial pressure (MAP) in a rat model of liver cirrhosis with portal hypertension, arterial hypotension, high cardiac output, and low systemic vascular resistance. |
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| DC36359 |
β-Apo-Oxytetracycline |
β-Apooxytetracycline is a potential impurity of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. β-Apooxytetracycline is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis. |
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| DC36360 |
Axitinib N-Glucuronide |
Axitinib N-Glucuronide is a metabolite of the receptor tyrosine kinase inhibitor Axitinib. It is formed via glucuronidation of axitinib by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1. |
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| DC36361 |
Phloretin-4-O-glucoside |
Trilobatin is a dihydrochalcone glucoside and derivative of phloretin that reduces survival of Bel 7402 and HepG2 cancer cells. Trilobatin increases superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity and inhibits lipid peroxidation. Pretreatment with trilobatin reduces hydrogen peroxide-induced cell death and production of mitochondrial reactive oxygen species (ROS), prevents reduction in the mitochondrial membrane potential, and increases the activity of GPX, SOD2, and isocitrate dehydrogenase 2 (IDH2) in PC12 neuronal cells. Trilobatin inhibits infection by various HIV-1 strains without inducing cytotoxicity in target cells. |
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| DC36362 |
Boc-Leu-Arg-Arg-AMC |
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. |
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| DC36363 |
CAP 3 |
CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii. CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. It is cytotoxic to A459 cells and has hemolytic activity against human red blood cells. |
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