| DC38076 |
BPD-Ring B |
LZN86178, also known as BPD-Ring B and benzoporphyrin Ring B derivative, is a product from the synthesis of verteporfinin. BPD-Ring B may be useful for making porphyrin-related dye, nanoparticles, photosensitizers, and other photodymanic therapeutic (PDT) drugs. LZN86178 has CAS#143986-17-8. For the convenience of scientific communication, tt is named as LZN86178 according to Hodoodo Chemical Nomenclature. |
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| DC38077 |
DBB-7373 |
DBB-7373, CAS#36287-37-3, is a Dibenzene-butandione derivative. DBB-7373 is a useful intermediate for synthesis of teremeprocol and other bioactive chemicals and drugs. |
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| DC38078 |
6-Chloro-1-tetralone |
6-Chloro-1-tetralone is an important intermediate for the synthesis of pharmaceutical compounds. |
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| DC38080 |
SMCC |
SMCC, also known as succinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate, is a heterobifunctional protein crosslinker. SMCC is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane-stabilized spacer arm (8.3 angstroms). SMCC conjugation occurs via a maleimide group that is sulfhydryl (thiol; -SH) reactive and a NHS ester group that is amine reactive and forms stable, covalent protein crosslinks. |
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| DC38081 |
Paclitaxel-Succinic acid |
Paclitaxel-Succinic acid, also known as Paclitaxel Succinate or Paclitaxel-hemisuccinic acid, is a paclitaxel derivative with a succinic acid linker. The carboxy group of Paclitaxel-Succinic acid, after activiating, can be used to conjugate with other molecules such as peptides, proteins, antibodies or enzymes, or polymers. Paclitaxel-Succinic acid is a useful agent to make Paclitaxel-conjugate for drug delivery, nanodrug research. |
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| DC38082 |
Paclitaxel-MVCP |
Paclitaxel-MVCP, also known as MC-Val-Cit-PAB-Paclitaxel, is a paclitaxel derivative with a MC-Val-Cit-PAB linker. Mc-Val-Cit-PAB is a cathepsin cleavable ADC peptide linker. Paclitaxel-MVCP can be used to conjugate with other molecules such as peptides, proteins, antibodies or enzymes, or polymers. Paclitaxel-MVCP is a useful agent to make Paclitaxel-conjugate for drug delivery, nanodrug research. |
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| DC38083 |
WZ4002-hydroxy |
WZ4002-hydroxy is a WZ4002 (MedKoo Cat#: 203170) derivative or WZ4002 analog. In which the methoxy group is replaced by hydroxy group. WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors. |
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| DC38084 |
WZ8040-hydroxy |
WZ8040-hydroxy is a WZ8040 (MedKoo Cat#406574) derivative or analog molecule. Compared to WZ8040, WZ8040-hydroxy has an extra hydroxy group in the benzene ring. WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor with potential anticancer activity. WZ8040 is about 30-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than other quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ-8040 may be clinically more effective and better tolerated than quinazoline-based inhibitors. |
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| DC38085 |
L-allo-Isoleucine |
L-allo-Isoleucine may be used in studies on maple syrup urine disease (MSUD). In patients with classical MSUD (n = 7), alloisoleucine was beyond the cutoff value in 2451 of 2453 unselected samples. In patients with variant MSUD (n = 9), alloisoleucine was >5 micromol/L in all samples taken for establishment of diagnosis and in 94% of the samples taken for treatment control (n = 624). With the other branched-chain amino acids, the frequency of diagnostically significant increases was <45%. The plasma L-alloisoleucine above the cutoff value of 5 micromol/L is the most specific and most sensitive diagnostic marker for all forms of MSUD. |
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| DC38086 |
PRP194 |
PRP-194, CAS#596085-87-9, has a chemical name 5-chloro-2,3,3-trimethyl-3H-pyrrolo[2,3-b]pyridine, is a useful precursor for chemical synthesis of bioactive molecules and dyes. There is no formal name for this chemical. For the convenience of communication, we temporally called it as PRP-194, in which PRP is originated from PyRrolo[2,3-b]Pyridine, and 194 is originated from its molecule weight 194. |
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| DC38087 |
Decyl-TPP |
Decyl-TPP, also known as (1-Decyl)triphenylphosphonium bromide, may be used as intermediate for chemical synthesis, Decyl-TPP can be also used as an inactive control or as a reference to mitoquinone (MitoQ). |
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| DC38088 |
MDK08445 |
MDK08445 is an important intermediate or precursor for the synthesis of Cefiderocol. MDK08445 has CAS#1225208-44-5. We assigned a code name as MDK08445 (last 5 digital of its CAS# was used). Cefiderocol, also known as S-649266, is a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. S-649266 shows potent in vitro activity against the non-fermenting Gram-negative bacteria Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, including MDR strains such as carbapenem-resistant A. baumannii and metallo-β-lactamase-producing P. aeruginosa. |
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| DC38089 |
MDK71803 |
MDK71803 is an important intermediate or precursor for the synthesis of Cefiderocol. MDK71803 has CAS#137171-80-3. We assigned a code name as MDK71803 (last 5 digital of its CAS# was used). Cefiderocol, also known as S-649266, is a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. S-649266 shows potent in vitro activity against the non-fermenting Gram-negative bacteria Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, including MDR strains such as carbapenem-resistant A. baumannii and metallo-β-lactamase-producing P. aeruginosa. |
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| DC38090 |
Biotin-PEG6-Maleimide |
Biotin-PEG6-Maleimide is a PEG derivative containing a biotin group and a maleimide group for labeling and crosslinking cysteines and other sulfhydryls. The maleimide group reacts specifically with sulfhydryl groups (at pH 6.5-7.5) to form a stable, irreversible thioether linkage. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules. |
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| DC38091 |
Fmoc-Val-Ala-PAB |
Fmoc-Val-Ala-PAB, also known as Fmoc-Val-Ala-PAB-OH, is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. |
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| DC38092 |
Mc-Val-Ala-PAB |
Mc-Val-Ala-PAB is a useful linker to make antibody-drug-conjugate (ADC) for targeting drug delivery. |
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| DC38093 |
8-((6-iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine |
The chemcial name of CAS# 873436-91-0 is 8-((6-iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine |
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| DC38094 |
t-Boc-N-amido-PEG9-amine |
t-Boc-N-amido-PEG9-amine is a PEG derivative containing an amino group and Boc-protected amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. PEG Linkers are useful in the development of antibody drug conjugates. |
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| DC38095 |
(R)-Ofloxacin |
(R)-Ofloxacin is a R-isomer of Ofloxacin, which is an antibiotic useful for the treatment of a number of bacterial infections. |
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| DC38096 |
HKI272 maleate |
Neratinib, also known as HKI-272 or PB272, is an orally available, irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. |
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| DC38098 |
Thiodipropionic acid |
Thiodipropionic acid is an organic disulfide used as a ligand for the synthesis of cadminum and zinc coordination polymers that have luminescent properties. |
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| DC38099 |
Exifone |
Exifone is a bioactive chemical. |
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| DC38100 |
p-Cresol |
para-Cresol, also 4-methylphenol, is an organic compound with the formula CH?C?H?. It is a colourless solid that is widely used intermediate in the production of other chemicals. |
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| DC38102 |
dimethoxydocetaxeld-6 |
Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB). |
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| DC38104 |
Phosphatidylcholines (PC) |
Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soybeans, from which they are mechanically or chemically extracted using hexane. They are also a member of the lecithin group of yellow-brownish fatty substances occurring in animal and plant tissues. Dipalmitoyl phosphatidylcholine (aka: lecithin) is a major component of pulmonary surfactant and is often used in the L/S ratio to calculate fetal lung maturity. While phosphatidylcholines are found in all plant and animal cells, they are absent in the membranes of most bacteria, including Escherichia coli. Purified phosphatidylcholine is produced commercially. |
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| DC40082 |
Yubeinine |
Yubeinine is an alkaloid, isolated from the bulbs of Fritillaria yuminensis. |
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| DC40120 |
(R)-Gyramide A hydrochloride |
(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 μM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 μM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV. |
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| DC40189 |
N1,N12-Diacetylspermine dihydrochloride |
N1,N12-Diacetylspermine dihydrochloride is a diacetylated derivative of spermine. Upregulation of N1,N12-Diacetylspermine dihydrochloride has been linked to the incidence of cancer, making it to be a potential biomarker for cancer detection. |
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| DC40202 |
Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside |
Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside, obtained from D-ribose, is an intermediate for the synthesis of riboside-containing arsenic compound. |
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| DC40203 |
Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside |
Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is an enantiomer of Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside. Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside is a derivative of L-ribose. |
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