| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC73990 | Equilin | Equilin (7-Dehydroestrone) is a highly potent 3βHSD1 inhibitor with IC50 of 2.8 nM in VCaP cells, also inhibits the activity of purified 3βHSD1 with SPR KD of 2.23 uM. |
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| DC73991 | Ethanimidothioic acid | Ethanimidothioic acid (R5421) is an inhibitor of platelet scramblase activity. |
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| DC73992 | EVT-701 | EVT-701 is a highly potent, selective, and safe mitochondrial complex 1 (MC1) inhibitor, reduces NADH abundance with IC50 of 300 nM. |
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| DC73993 | F12511 | Eflucimibe (F 12511) is a highly potent, selective inhibitor of acyl-CoA: cholesterol acyltransferase ( ACAT/SOAT) with IC50 of 3, 7, and 71 nM in whole cell assays using HepG2, CaCo-2 and THP-1 cell lines, respectively. |
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| DC73994 | F759 | F759 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets. |
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| DC73995 | F83236 | F83236 is a nonpeptidic small-molecule cyclophilin inhibitor, inhibits coagulation induced by procoagulant platelets. |
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| DC73996 | FDW028 | FDW028 is a potent and highly selective small-molecule inhibitor of fucosyltransferase 8 (FUT8) with binding KD value of 5.486 uM, displays no affinity against other FUTs, shows potent anti-CRC activities. |
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| DC73997 | Feeblin | Feeblin (SLC15A4 inhibitor C5) is a small molecule inhibitor of the proinflammatory TLR7/8/9-IRF5 pathway (IC50=1.6 uM) by disrupting the SLC15A4-TASL adapter module, Feeblin is an IRF5 pathway-specific inhibitor. |
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| DC73998 | FK3453 | FK3453 (FK 3453) is a novel inhibitor of thymic stromal lymphopoietin (TSLP) production, reduces both TSLP protein levels and mRNA levels both in vitro and in vivo. |
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| DC73999 | FMP-201300 | FMP-201300 is a potent, selective and allosteric inhibitor of the unique valine gatekeeper mutants of IP6K1 and IP6K2 with IC50 of 114/190 nM for IP6K1 L210V and IP6K2 L210V mutants respectively. |
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| DC74000 | GCN2iA | GCN2iA is a potent seletive inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 4.0 nM. |
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| DC74001 | GE1111 | GE1111 is a novel potent small molecule Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist, significantly inhibits mast cells degranulation and MRGPRX2 activation with IC50 of 5 uM. |
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| DC74002 | GMFBI.1 | GMFBI.1 is a small molecule that specifically block Ser83 phosphorylation site on Glia maturation factor-β (GMF-β), directly binds to hGMF-β protein with Kd of 19.9 uM. |
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| DC74003 | GNE-1858 | GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 with IC50 of 1.9 nM in the SLP76 phosphorylation assay. |
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| DC74004 | GNF362 | GNF362 (GNF-362) is a highly potent, selective inhibitor of inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) with IC50 of 9 nM. |
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| DC74005 | GNF-9228 | GNF-9228 is a small molecule that stimulates human β-cell proliferation, selectively activates human β-cell relative to α- or δ-cell proliferation. |
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| DC74006 | GO-203 | GO-203 (GO203) is a cell-penetrating peptide inhibitor of mucin-1-cycloplasmic C-terminal subunit (MUC1-C), blocks homodimerization of the MUC1-C subunit required for nuclear translocation and downstream signaling. |
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| DC74007 | GQ352 | GQ352 is a small molecule Gαq/11 inhibitor, directly binds to the Gαq and inhibits the dissociation of Gαβγ heterotrimers with IC50 value of 8.9 uM. |
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| DC74008 | GSK898 | GSK898 is a potent, highly selective kynurenine monooxygenase (KMO) inhibitor with pIC50 of 8.8. |
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| DC74009 | H3B-616 | H3B-616 (H3B 616) is a potent, selective allosteric inhibitor of CPS1 with IC50 of 66 nM, demonstrates no appreciable inhibition of CPS2 (IC50>100 uM). |
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| DC74010 | HB-MIX1902 Supplement (10X) | HB-MIX1902 Supplement (10X) is an optimized serum-free supplement used to promote and maintain the growth, maturity and viability of iPS-derived hepatic and biliary cells. MIX1902 is provided as a 10X liquid and is intended to be used with Hepatocyte Cult |
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| DC74011 | HJ445A | HJ445A is a highly potent, selective myoferlin (MYOF) inhibitor, binds to MYOF-C2D domain with KD value of 0.17 uM. |
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| DC74012 | HP661 | HP661 is a potent, and selective oral complex I OXPHOS inhibitor with 76% inhibition at 1u M in H460 cells using electron flow assays, inhibits high-OXPHOS H460 cell viability with IC50 of 5 nM. |
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| DC74013 | HPK1 PROTAC SS44 | HPK1 PROTAC SS44 is a heterobifunctional small molecule based on ZYF0033 that simultaneously binds HPK1 and E3 ligase Cereblon (CRBN), induces degradation of HPK1. |
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| DC74014 | HQY426 | HQY426 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.32 uM, exhibits potent antitumor activity. |
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| DC74015 | HQY436 | HQY436 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.15 uM, exhibits potent antitumor activity. |
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| DC74016 | HsClpP activator ZK53 | HsClpP activator ZK53 is a potent, selective activator of mitochondrial caseinolytic protease P (HsClpP) with EC50 of 0.22 uM in FI-based protease activity assays, inactive toward bacterial ClpP proteins. |
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| DC74017 | HTL0041178 Featured | HTL0041178 is a potent GPR52 agonist with EC50 of 27.5 nM (human or rat GPR52). |
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| DC74018 | HTS13286 | HTS13286 is a selective AQP9 inhibitor with IC50 of 1.5 uM (inhibition of CHO-AQP9 cell water permeability). |
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| DC74019 | HYGIC | HYGIC is a small molecule that simultaneously induces hypocotyl elongation and thickening via the ethylene signaling pathway activated by endogenous ethylene. |
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