| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC20416 | Imipramine Blue | A potent STAT5 inhibitor with a dual mechanism of action, potently inhibits STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition at 200-300 nM. |
|
| DC22933 | TLR7-Agonist-31 | A potent TLR7 agonist with EC50 of 59 nM.. |
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| DC22932 | TLR7-Agonist-54 | A potent TLR7 agonist with EC50 of 8.6 nM. . |
|
| DC22393 | IW-927 | A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM). |
|
| DC22618 | MMAD hydrochloride | A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).. |
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| DC22607 | Masitinib mesylate | A potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays. |
|
| DC23995 | Lck inhibitor 2 Featured | A potent tyrosine kinases inhibitor with IC50 of 13/9/3/26/2 nM for Lck/Btk/Lyn/Syk/Txk.. |
|
| DC22374 | BMS-299897 | A potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM. |
|
| DC24011 | (±)-BI-D | A potent, allosteric HIV integrase inhibitor (Kd=34 nM) that binds the LEDGF/p75 binding site on integrase. |
|
| DC20541 | RUNX1-IN-17 | A potent, allosteric inhibitor of CBFβ-RUNX1 interaction with IC50 of 3.2 uM in FRET assays. |
|
| DC23288 | SMBA1 | A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation. |
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| DC23992 | FAAH inhibitor 1 | A potent, and selective FAAH inhibitor with IC50 of 18 nM. |
|
| DC22748 | UBP 302 | A potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM. |
|
| DC20475 | Nek2 inhibitor 72 | A potent, ATP-competitive and relative selective Nek2 inhibitor with IC50 of 0.27 uM. |
|
| DC23063 | FAUC 1104 | A potent, biased allosteric agonist of CXCR3 (pEC50=5.22) that activates solely G proteins, induces chemotaxis, but fails to induce receptor internalization or β-arrestin 2 recruitment.. |
|
| DC23064 | FAUC 1036 | A potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins.. |
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| DC22801 | MK2 inhibitor III | A potent, cell-permeable inhibitor of MK2 with IC50 of 8.5 nM. |
|
| DC20868 | CCG-203586 | A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM. |
|
| DC22472 | Naltrexone Featured | A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively. |
|
| DC22615 | Rosuvastatin | A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM. |
|
| DC20318 | BCML | A potent, competitive inhibitor of quinine-activated bitter taste receptor T2R4 with IC50 of 59 nM.. |
|
| DC20702 | Ilepatril | A potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively. |
|
| DC23394 | Dual BET-Kinase inhibitor 3 | A potent, dual BET bromodomain-kinase inhibitor with IC50 of 34, 1.1 and 1.1 nM for BRD4 BD1, JAK2 and FLT-3, respectively. |
|
| DC20885 | CGP-74514A | A potent, dual CDC-like kinase (CLK)/CDK inhibitor with IC50 of 148, 111, 104, 382 and 573 nM for CLK1, CLK2, CLK4, CDK1 and CDK4, respectively.. |
|
| DC24059 | PI-103 hydrochloride Featured | A potent, dual class I PI3K/mTOR inhibitor with IC50 of 2/3/3/15/ for p110α/β/δ/γ, respectively. |
|
| DC21562 | Pz-1 | A potent, dual pan-RET/VEGFR2 kinase inhibitor with IC50s of <1 nM for all RET, RET V804M and VEGFR2. |
|
| DC20542 | SA 16 | A potent, dual PDK1 and Aurora kinase A inhibitor with IC50 of 416 and 35 nM, respectively. |
|
| DC22545 | TG 100572 hydrochloride | A potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family. |
|
| DC23967 | TG 100572 | A potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family. |
|
| DC20663 | AMG 511 | A potent, efficacious, and orally available pan class I PI3K inhibitor with Ki of 4/6/2/1 nM for PI3Kα/β/δ/γ, respectively. |
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