| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22560 | TCV-309 chloride | A highly potent and selective platelet activating factor (PAF) antagonist. |
|
| DC24134 | GCGR-IN-1 | A highly potent glucagon receptor antagonist.. |
|
| DC24083 | 4-IBP Featured | A highly potent sigma receptor agonist with Ki of 1.7 nM and 25.2 nM for σ1 and σ2, respectively. |
|
| DC21813 | MT-7716 | A highly potent, brain-penetrating ORL1 receptor (NOP receptor) agonist with Ki of 0.76 and 0.50 nM for rat and human ORL1 receptors, respectively. |
|
| DC21258 | LY 2812223 | A highly potent, functionally selective mGlu2 receptor agonist with EC50 of 13.6 nM in GTPγS functional binding assay. |
|
| DC23409 | AZD 8683 | A highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4. |
|
| DC22822 | Saxagliptin hydrate | A highly potent, long-acting, orally active DPP4 inhibitor with Ki of 0.6 nM. |
|
| DC23848 | YM-359445 | A highly potent, orally active VEGFR-2 inhibitor with IC50 of 8.5 nM, without activity against PKA, PKCα, PDK-1 and JNK3 (IC50>1 uM). |
|
| DC24063 | Cediranib maleate Featured | A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively. |
|
| DC21588 | RS 102221 | A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively. |
|
| DC21690 | SR 144528 | A highly potent, selective and orally active antagonist of CB2 receptor with Ki of 0.6 nM. |
|
| DC23424 | RO 5256390 Featured | A highly potent, selective and orally bioavailable trace amine-associated receptor 1 (TRRA1) full agonist with EC50 of 18 nM, >500-fold selectivity over human adrenergic α2A receptor. |
|
| DC21582 | RO 5263397 | A highly potent, selective and orally bioavailable trace amine-associated receptor 1 (TRRA1) partial agonist with EC50 of 17 nM, >1,000-fold selectivity over human adrenergic α2A receptor. |
|
| DC20333 | Cdc7 inhibitor 7c | A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively. |
|
| DC22919 | POL3026 | A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.2 nM in Ca2+ flux assay. |
|
| DC22918 | POL2438 | A highly potent, selective beta-hairpin mimetic CXCR4 inhibitor with IC50 of 1.9 nM in Ca2+ flux assay. |
|
| DC22342 | MK-3207 | A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay. |
|
| DC20924 | CPI-1205 | A highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM. |
|
| DC20598 | 2-BFI hydrochloride | A highly potent, selective imidazoline I2 receptor agonist with Ki of 9.8 nM, enhances supraspinal morphine analgesia in mice.. |
|
| DC23339 | NTRC 00660 | A highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM. |
|
| DC23478 | MRS-2365 | A highly potent, selective P2Y1 receptor agonist with EC50 of 1.2 nM. |
|
| DC20935 | CV-6209 | A highly potent, selective platelet activating factor (PAF) inhibitor with IC50 of 75 and 170 nM for aggregation inhibition of rabbit and human platelets induced by PAF. |
|
| DC23518 | PF-470 | A highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM. |
|
| DC21658 | SKI-2852 | A highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively. |
|
| DC20964 | Razaxaban | A highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases. |
|
| DC20965 | Razaxaban hydrochloride | A highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases. |
|
| DC23466 | GRN-529 | A highly potent, selective, orally active mGluR5 negative allosteric modulator with Ki of 5.4 nM, IC50 of 3.1 nM. |
|
| DC23863 | eCF506 | A highly potent, selective, orally available Src family kinase inhibitor with IC50 of <0.5 nM, <0.5 nM and for Src, Yes and Fyn kinases respectively, >950-fold selectivity for Src over ABL. |
|
| DC23972 | MK-2894 sodium | A highly potent, selective, second generation prostaglandin E2 subtype 4 receptor (EP4) antagonist with Ki of 0.56 nM. |
|
| DC22972 | S-17092 | A highly potent, specific and cell permeant inhibitor of human proline endopeptidase (PE) with Ki of 1 nM. |
|
