| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC21815 | WAY 163909 | A highly potent, subtype-selective agonist of 5-HT2C receptor with Ki of 10.5 nM, >20-fold selectivity over 5-HT2A and 5-HT2B receptor subtypes (IC50=212 and 485 nM, respectively). |
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| DC26071 | BMS-814580 Featured | A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM. |
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| DC26070 | BMS 814580 phosphate | A highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM. |
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| DC22776 | CCG-224406 | A highly selective and potent GRK2 (G protein-coupled receptor kinase 2) inhibitor with IC50 of 130 nM. |
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| DC23953 | Orteronel | A highly selective CYP17A1 (17,20-lyase) inhibitor with IC50 of 17 nM for human 17,20-lyase. |
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| DC24016 | Ribocil-C | A highly selective inhibitor of the FMN riboswitch that controls expression of de novo riboflavin (Vitamin B2) biosynthesis in Escherichia coli. |
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| DC24089 | KX2-391 mesylate Featured | A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor. |
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| DC24090 | KX2-391 dihydrochloride Featured | A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor. |
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| DC22902 | SNC-80 Featured | SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment. |
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| DC20704 | AVN-322 free base | A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia. |
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| DC20707 | AVN-322 | A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia. |
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| DC23330 | pdTp | A highly selective, small molecule inhibitor of the miRNA regulatory complex RISC subunit SND1. |
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| DC24154 | BTS | A highly specific myosin II ATPase inhibitor. |
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| DC20705 | AVN-101 | A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki = 1.2-2.0 nM). |
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| DC20525 | Quinobene | A HIV-1 surface-membrane inhibitor, also is a Fap1-blocking small molecule that replicates SLV peptied functions. |
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| DC21411 | Thioflavin S | A homogenous mixture of compound that is used to stain amyloid plaques, binds to amyloid fibrils but not monomers and gives a distinct increase in fluorescence emission.. |
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| DC22453 | Sappanone A Featured | A homoisoflavanone found in Caesalpinia sappan, a potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with Kd of 3.944 nM, almost 10 times lower than the Kd of binding to IMPDH1. |
|
| DC24087 | Calcipotriol monohydrate Featured | A hormonally active metabolite of vitamin D that binds to vitamin D receptor (VDR). |
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| DC23962 | Cilobradine Featured | A hyperpolarization-activated cyclic nucleotide-gated (HCN) channel. |
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| DC23269 | Carrageenan | A linear sulfated polysaccharide extracted from red edible seaweeds, shows topical microbicide activity targeting HIV viruses. |
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| DCAPI1556 | Cinchocaine HCL | A local anesthetic. |
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| DC24160 | Benzydamine hydrochloride | A locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions. |
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| DC22626 | Bambuterol | A long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma. |
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| DC20991 | Etacrynic acid | A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue. |
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| DC22825 | Azathramycin | A macrolide antibiotic that effectively inhibits tumor angiogenesis by suppressing VEGFR2-mediated signaling pathways in lung cancer. |
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| DC21367 | NC1153 | A Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b. |
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| DC25020 | Seriniquinone | A melanoma-selective anticancer agent (IC50=30 nM, Malme-3M cell line), induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin. |
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| DC24056 | Agomelatine hydrochloride Featured | A melatonin receptor agonist of MT1 (Ki=0.1nM) and MT2 (Ki=0.12nM), and a 5-HT2C (Ki=631nM) receptor antagonist. |
|
| DC24055 | Agomelatine L(+)-Tartaric acid Featured | A melatonin receptor agonist of MT1 (Ki=0.1nM) and MT2 (Ki=0.12nM), and a 5-HT2C (Ki=631nM) receptor antagonist. |
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| DC26095 | QX 314 chloride Featured | A membrane-impermeable sodium channel blocker, blocks sodium current in voltage-clamped nociceptive DRG neurons. |
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